Results 301 to 310 of about 198,787 (385)

Synthesis of a Pseudocytidine Nucleoside to Form a Stable and Selective Base Pair with Iso-guanosine in RNA. [PDF]

Org Lett
Miyahara R, Taniguchi Y.
europepmc   +1 more source

Non‐canonical nitric oxide signalling and DNA methylation: Inflammation induced epigenetic alterations and potential drug targets

British Journal of Pharmacology, EarlyView.
Abstract DNA methylation controls DNA accessibility to transcription factors and other regulatory proteins, thereby affecting gene expression and hence cellular identity and function. As epigenetic modifications control the transcriptome, epigenetic dysfunction is strongly associated with pathological conditions and ageing.
Christopher H. Switzer
wiley   +1 more source

Recent progress in the application of hydrophilic interaction liquid chromatography for the separation and analysis of traditional Chinese medicine. [PDF]

Front Chem
Wu Y, Huang H, Zhao X, Lin J, Guo J, Jiang Z, Ar-Sanork K, Deng T, Xu D.   +8 more
europepmc   +1 more source

The potential for biased signalling in the P2Y receptor family of GPCRs

British Journal of Pharmacology, EarlyView.
The purinergic receptor family is primarily activated by nucleotides, and contains members of both the G protein coupled‐receptor (GPCR) superfamily (P1 and P2Y) and ligand‐gated ion channels (P2X). The P2Y receptors are widely expressed in the human body, and given the ubiquitous nature of nucleotides, purinergic signalling is involved with a plethora
Claudia M. Sisk, Simon Pitchford, Graham Ladds   +2 more
wiley   +1 more source

Nanoparticle-assisted strategies in mass spectrometry-based metabolite analysis: recent advances across analytical workflow. [PDF]

Mikrochim Acta
Gamboa-Becerra R, Beltrán-Partida E, Valdez-Salas B, Castillo-Saenz J, Salvador-Carlos J, Curiel-Álvarez M.   +5 more
europepmc   +1 more source

Organoid Models to Study Human Infectious Diseases

Cell Proliferation, EarlyView.
Our manuscript reviews the role of organoids as models for studying human infectious diseases, highlighting their irreplaceable contributions to drug testing and vaccine development for significant infectious diseases including HIV, ZIKV, SARS‐CoV‐2 and MPXV.
Sijing Zhu, Dan Chen, Xinzhi Yang, Liuliu Yang, Yuling Han   +4 more
wiley   +1 more source

A scope of prebiotic neat reaction conditions and the mechanism of urea-assisted phosphorylations of alcohols. [PDF]

Nat Commun
Shvetsova A, Merzoud L, Lopez A, Fromentin E, Baudouin A, Chermette H, Daniel I, Fiore M, Strazewski P.   +8 more
europepmc   +1 more source

Glutaminase‐1 Mediated Glutaminolysis to Glutathione Synthesis Maintains Redox Homeostasis and Modulates Ferroptosis Sensitivity in Cancer Cells

Cell Proliferation, EarlyView.
GLS1‐mediated glutaminolysis supports GSH synthesis in cancer cells. GLS1 KO increases ROS, downregulates GPX4, and upregulates GPX1, making cells more sensitive to ferroptosis. Combining GLS1 or GPX1 inhibitors with a GPX4 inhibitor synergistically suppresses cancer growth.
Changsen Bai, Jialei Hua, Donghua Meng, Yue Xu, Benfu Zhong, Miao Liu, Zhaosong Wang, Wei Zhou, Liming Liu, Hailong Wang, Yang Liu, Lifang Li, Xiuju Chen, Yueguo Li   +13 more
wiley   +1 more source

The Signature of Serum Modified Nucleosides in Uveitis. [PDF]

Invest Ophthalmol Vis Sci
Zhou H, Hu Y, Qin G, Kong J, Hong X, Guo C, Zou J, Feng L.   +7 more
europepmc   +1 more source