Results 311 to 320 of about 198,787 (385)

The Role of SAMHD1 in Viral Resistance and Transduction Efficiency Challenges in Pediatric Hematological Malignancies: Mechanistic Insights and Clinical Perspectives

European Journal of Haematology, EarlyView.
SAMHD1 regulates intracellular dNTP pools, influencing lentiviral transduction, gene therapy efficiency, and disease progression in pediatric hematological malignancies. Integrated bioinformatics and targeted strategies, including CRISPR and pharmacological inhibition, highlight its therapeutic potential.
Waseem Alzamzami
wiley   +1 more source

Mediated Electrochemical Oxidation of Nucleosides to Their 5'-Carboxylic Acid Derivatives. [PDF]

Chemistry
Abrams DJ, Johnson MR, Lacker CR, Yoon TP, Martinelli JR, Stahl SS.   +5 more
europepmc   +1 more source

Synthese neuer Apoptose-induzierender Nucleosidanaloga mit Butadien-Fe(CO)3-Substruktur zur Aufklärung des Wirkmechanismus und Verbesserungen der biologischen Eigenschaften [PDF]

, 2008
Hirschhäuser, Christoph
core  

Drug discovery and preclinical testing of drug candidates for developmental and epileptic encephalopathies

Epilepsia, EarlyView.
Abstract Drug development for developmental and epileptic encephalopathies (DEEs) follows different strategies on one hand including disease‐targeting precision medicine approaches considering the genetic variants and pathomechanisms in DEEs and on the other hand including therapeutic approaches with novel targets or second‐generation drug candidates ...
Heidrun Potschka, Daniel Pérez‐Pérez
wiley   +1 more source

Ionization of DNA Nucleotides in Explicit Solution. [PDF]

Molecules
Bai J, Zhang Y, Yin S, Che L, Yang S.
europepmc   +1 more source

Preparation of Organometallic Complexed Sugars:  Hetero Diels−Alder Reactivity of Tricarbonyl(formyltrimethylenemethane)- iron [PDF]

, 1997
Donaldson, William, Kleindl, Paul J.
core   +1 more source

Natural occurrence of drug resistance mutations to the HIV‐1 capsid inhibitor lenacapavir

HIV Medicine, EarlyView.
Abstract Aims Lenacapavir (LEN) is a first‐in‐class HIV‐1 capsid inhibitor. We investigated the natural occurrence of LEN drug resistance mutations (DRM) in HIV‐1 sequences from LEN treatment‐naïve individuals. Methods We analysed all available HIV‐1 capsid sequences (n = 21 646) from individuals never exposed to LEN from the Los Alamos National ...
A. Weibull Wärnberg, R. Ceña‐Diez, A. Sönnerborg, M. A. A. van de Klundert   +3 more
wiley   +1 more source

Fundamental Role of N-O Bond-Containing Compounds in Prebiotic Synthesis. [PDF]

JACS Au
Sukhorukov AY.
europepmc   +1 more source

HPLC Analysis of tRNA-Derived Nucleosides. [PDF]

Bio Protoc
Chen X, Xu F.
europepmc   +1 more source

New cases expand the genotype, phenotype and therapeutic landscape of H syndrome

British Journal of Haematology, EarlyView.
Clément Triaille, Julie Beauchemin, Philippe M. Campeau, Hugo Chapdelaine, Julie Dery, Maria Kondyli, Grant Mitchell, Julie Powell, Sophie Turpin, Guilhem Cros, Fabien Touzot   +10 more
wiley   +1 more source