Results 311 to 320 of about 193,772 (411)

Weiss or Wit: Chemical Profiling of Wheat Beers via NMR-Based Metabolomics. [PDF]

Foods
Chorbadzhiev P, Gerginova D, Simova S.
europepmc   +1 more source

H syndrome presenting with bilateral cheek enlargement and an <i>SLC29A3</i> gene variant. [PDF]

BMJ Case Rep
Lim KK, Taguibao JJN, Plando LAKC, Dayrit-Castro CAF.   +3 more
europepmc   +1 more source

Non‐canonical nitric oxide signalling and DNA methylation: Inflammation induced epigenetic alterations and potential drug targets

British Journal of Pharmacology, EarlyView.
Abstract DNA methylation controls DNA accessibility to transcription factors and other regulatory proteins, thereby affecting gene expression and hence cellular identity and function. As epigenetic modifications control the transcriptome, epigenetic dysfunction is strongly associated with pathological conditions and ageing.
Christopher H. Switzer
wiley   +1 more source

Nucleoside Analogues for Chagas Disease and Leishmaniasis Therapy: Current Status and Future Perspectives. [PDF]

Molecules
Nwoke EA, Lowe S, Aldabbagh F, Kalesh K, Kadri H.   +4 more
europepmc   +1 more source

Innovative pharmacotherapy for hepatic metabolic and chronic inflammatory diseases in China

British Journal of Pharmacology, EarlyView.
Abstract Liver disease constitutes a significant global health concern, particularly in China where it has distinctive characteristics. China grapples with a staggering 300 million cases, predominantly due to hepatitis B and metabolic non‐alcoholic fatty liver disease. Additionally, hepatocellular carcinoma has become a prevalent which is a lethal type
Feng Zhang, Jiaming Ju, Hongtao Diao, Jinglun Song, Yu bian, Baofeng Yang   +5 more
wiley   +1 more source

Biocatalytic synthesis of ribonucleoside analogues using nucleoside transglycosylase-2. [PDF]

Chem Sci
Salihovic A, Ascham A, Rosenqvist PS, Taladriz-Sender A, Hoskisson PA, Hodgson DRW, Grogan G, Burley GA.   +7 more
europepmc   +1 more source

Phenotypic screening of a focused nucleoside library [PDF]

, 2016
Hulpia, Fabian, Van Calenbergh, Serge
core  

Progress on the development of Class A GPCR‐biased ligands

British Journal of Pharmacology, EarlyView.
Class A G protein‐coupled receptors (GPCRs) continue to garner interest for their essential roles in cell signalling and their importance as drug targets. Although numerous drugs in the clinic target these receptors, over 60% GPCRs remain unexploited. Moreover, the adverse effects triggered by the available unbiased GPCR modulators, limit their use and
Paula Morales, Magdalena M. Scharf, Marcel Bermudez, Attila Egyed, Rafael Franco, Olivia K. Hansen, Nadine Jagerovic, Jan Jakubík, György M. Keserű, Dóra Judit Kiss, Pawel Kozielewicz, Olav Larsen, Maria Majellaro, Ana Mallo‐Abreu, Gemma Navarro, Rubén Prieto‐Díaz, Mette M. Rosenkilde, Eddy Sotelo, Holger Stark, Tobias Werner, Laura M. Wingler   +20 more
wiley   +1 more source

Aminomethylmorpholino Nucleosides as Novel Inhibitors of PARP1 and PARP2: Experimental and Molecular Modeling Analyses of Their Selectivity and Mechanism of Action. [PDF]

Int J Mol Sci
Chernyshova I, Vasil'eva I, Moor N, Ivanisenko N, Kutuzov M, Abramova T, Zakharenko A, Lavrik O.   +7 more
europepmc   +1 more source

P2Y14 receptor activation of platelets induces Ca2+ mobilization and Rho‐GTPase‐dependent motility that requires an interaction with P2Y1 receptors

British Journal of Pharmacology, EarlyView.
Background and Purpose Platelet function during inflammation is dependent on activation by endogenous nucleotides acting on purinergic receptors. The P2Y14 receptor has been reported to be expressed on platelets and is involved in leukocyte recruitment during inflammation.
Md Monir Hossain, Dingxin Pan, Kate L. Arkless, Khondaker Miraz Rahman, Clive P. Page, Kalwant S. Authi, Simon C. Pitchford   +6 more
wiley   +1 more source