Results 321 to 330 of about 193,772 (411)

[Current advances in the analysis of free RNA modified nucleosides by high performance liquid chromatography-tandem mass spectrometry]. [PDF]

Se Pu
Zhang LY, Zhang WB, Wang HL.
europepmc   +1 more source

Klebsiella pneumoniae contributes to altered cytotoxicity of thiopurines in vitro: Possible implications of biotransformation and bacterial metabolism

British Journal of Pharmacology, EarlyView.
Abstract Background and purpose Thiopurines are used in paediatric inflammatory bowel disease (IBD), but some patients do not respond. Because the gut microbiota influences drug efficacy and IBD‐patient microbiota presents increased bacterial abundance, we investigated the impact of candidate Enterobacteriaceae on drug cytotoxicity, metabolism and ...
Martina Franzin, Cristina Lagatolla, Sofia Sindici Forgiarini, Mathias Haag, Sylvia Karin Neef, Manola Comar, Elke Schaeffeler, Barbara Bellich, Matteo Bramuzzo, Giuliana Decorti, Marianna Lucafò, Ute Hofmann, Matthias Schwab, Gabriele Stocco   +13 more
wiley   +1 more source

Regioselective Deacetylation in Nucleosides and Derivatives. [PDF]

Chembiochem
Grabbe C, Cai L.
europepmc   +1 more source

Synthesis of 1’-N-homoazanucleosides as potential transition state analogues and antiviral agents [PDF]

, 2016
Bouton, Jakob, Van Calenbergh, Serge
core  

Novel Approach to Overcome Osimertinib Resistance Using Bromodomain and Extra‐Terminal Domain Inhibitors

Cancer Science, Volume 116, Issue 5, Page 1392-1404, May 2025.
Our study found that epigenetic changes, particularly histone modifications regulating FGF1, contribute to osimertinib resistance. Targeting these modifications with BET inhibitors may offer new therapeutic strategies. ABSTRACT Osimertinib, a third‐generation EGFR‐tyrosine kinase inhibitor, is the first‐line therapy for lung cancer harboring EGFR ...
Yosuke Miyashita, Ken Tajima, Kenta Izumi, Naohisa Matsumoto, Daisuke Hayakawa, Ikuko Takeda Nakamura, Isana Katayama, Adityo Wibowo, Hironari Matsuda, Wira Winardi, Bagus Radityo Amien, Yoichiro Mitsuishi, Fumiyuki Takahashi, Kohta Nakamura, Ken Uchibori, Noriko Yanagitani, Takuo Hayashi, Kazuya Takamochi, Kenji Suzuki, Ryohei Katayama, Kazuhisa Takahashi   +20 more
wiley   +1 more source

The novel biomarker t⁶A accurately identified septic patients at admission but failed to predict outcome. [PDF]

Crit Care
Osuchowski MF, Adamik B, Gozdzik W, Skalec T, Mascher D, Redl H, Zipperle J, Fritsch G, Voelckel W, Winkler MS, Moerer O, Schütz H, Mascher H.   +12 more
europepmc   +1 more source

Organoid Models to Study Human Infectious Diseases

Cell Proliferation, EarlyView.
Our manuscript reviews the role of organoids as models for studying human infectious diseases, highlighting their irreplaceable contributions to drug testing and vaccine development for significant infectious diseases including HIV, ZIKV, SARS‐CoV‐2 and MPXV.
Sijing Zhu, Dan Chen, Xinzhi Yang, Liuliu Yang, Yuling Han   +4 more
wiley   +1 more source

Correction: Schaltz et al. A Theoretical Study of Hydrogen Abstraction Reactions in Guanosine and Uridine. Int. J. Mol. Sci. 2023, 24, 8192. [PDF]

Int J Mol Sci
Schaltz KF, Sauer SPA.
europepmc   +1 more source

Glutaminase‐1 Mediated Glutaminolysis to Glutathione Synthesis Maintains Redox Homeostasis and Modulates Ferroptosis Sensitivity in Cancer Cells

Cell Proliferation, EarlyView.
GLS1‐mediated glutaminolysis supports GSH synthesis in cancer cells. GLS1 KO increases ROS, downregulates GPX4, and upregulates GPX1, making cells more sensitive to ferroptosis. Combining GLS1 or GPX1 inhibitors with a GPX4 inhibitor synergistically suppresses cancer growth.
Changsen Bai, Jialei Hua, Donghua Meng, Yue Xu, Benfu Zhong, Miao Liu, Zhaosong Wang, Wei Zhou, Liming Liu, Hailong Wang, Yang Liu, Lifang Li, Xiuju Chen, Yueguo Li   +13 more
wiley   +1 more source

50 years in the making: acp³U, an amino-acid-containing nucleoside, links N-glycans and RNA in glycoRNA. [PDF]

Mol Cell
Steinbuch KB, Tor Y.
europepmc   +1 more source