Results 321 to 330 of about 197,362 (384)
Optimizing scheduling in dual-pulse nucleoside labeling experiments for cell cycle analysis
Phelan A, Pospori C, Lo Celso C, Lee CF.
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4'-Modified Nucleosides for Antiviral Drug Discovery: Achievements and Perspectives.
Accounts of Chemical Research, 2022ConspectusModified nucleosides show therapeutic promise for antiviral therapies. However, issues including the emergence of drug resistance, toxicity, and coinfections have posed new challenges for nucleoside-based antiviral drug discovery, particularly ...
Junbiao Chang
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Phosphorylation of nucleosides and nucleoside analogs by mammalian nucleoside monophosphate kinases
Pharmacology & Therapeutics, 2000Nucleoside monophosphate kinases catalyze the reversible phosphotransferase reaction between nucleoside triphosphates and monophosphates, i.e., monophosphates are converted to their corresponding diphosphate form. These enzymes play an important role in the synthesis of nucleotides that are required for a variety of cellular metabolic processes, as ...
Anna Karlsson +2 more
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Advancement in the development of heterocyclic nucleosides for the treatment of cancer - A review
Nucleosides, Nucleotides & Nucleic Acids, 2019Cancer diseases are widely recognised as an important medical problem and killing millions of people in a year. Chemotherapeutic drugs are successful against cancer in many cases and different compounds, including the analogues of natural substances, may
A. Mirza
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Journal of Chromatography A, 1980
Abstract The chromatographic parameters affectingthe reversed-phase high-performance liquid chromatographic (HPLC) separation of major and modified nucleosides with a μBondapak C 18 column have been studied. This investigation has resulted in the HPLC separation of eighteen nucleosides in a single analysis. The parameters studied include: the mobile
Kenneth C. Kuo +2 more
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Abstract The chromatographic parameters affectingthe reversed-phase high-performance liquid chromatographic (HPLC) separation of major and modified nucleosides with a μBondapak C 18 column have been studied. This investigation has resulted in the HPLC separation of eighteen nucleosides in a single analysis. The parameters studied include: the mobile
Kenneth C. Kuo +2 more
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Experientia, 1970
Mit N-Bromsuccinimid konnen Nukleoside in Dimethylformamid mit guter Ausbeute zu den in 5-Stellung bromierten Derivaten umgewandelt werden.
K. L. Nagpal, P. C. Srivastava
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Mit N-Bromsuccinimid konnen Nukleoside in Dimethylformamid mit guter Ausbeute zu den in 5-Stellung bromierten Derivaten umgewandelt werden.
K. L. Nagpal, P. C. Srivastava
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Biochimica et Biophysica Acta (BBA) - Nucleic Acids and Protein Synthesis, 1974
Abstract The dipole moments of a series of model pyrimidine nucleosides were determined experimentally. Comparison was made between the experimental values and those vectorially calculated as a function of nucleoside conformation. This analysis alone does not permit the unequivocal determination of the conformation of the nucleoside in solution, but ...
Andrzej Rabczenko, I. Kulakowska
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Abstract The dipole moments of a series of model pyrimidine nucleosides were determined experimentally. Comparison was made between the experimental values and those vectorially calculated as a function of nucleoside conformation. This analysis alone does not permit the unequivocal determination of the conformation of the nucleoside in solution, but ...
Andrzej Rabczenko, I. Kulakowska
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