Results 181 to 190 of about 75,018 (265)

Molecular basis for the regulation of retroviral nucleosomal integration by chromatin compaction. [PDF]

Nucleic Acids Res
Lapaillerie D, Zgadzay Y, Martins FG, Bertinetti C, Autin M, Batisse J, Tumiotto C, Lesbats P, Ruff M, Sousa SF, Parissi V.   +10 more
europepmc   +1 more source

A Three‐Dimensional Culture–Drug Sensitivity Test Predicts MDM2 Inhibitor–Sensitivity in SMARCB1/INI1‐Deficient Tumors

Cancer Science, Volume 117, Issue 10, Page 2852-2862, October 2026.
This study aimed to determine whether personalized selection of effective drugs for SMARCB1/INI1‐deficient tumors is feasible using in vitro drug sensitivity profiling. Drug sensitivity was assessed using a short‐term collagen gel–embedded three‐dimensional drug sensitivity test (3D‐DST) in tumors derived from SMARCB1/INI1‐deficient tumor cell line ...
Hiroaki Goto, Chiyoko Nishime, Takashi Ohtsu, Mieko Ito, Maiko Sagisaka, Takuya Naruto, Norihiko Kitagawa, Mio Tanaka, Masakatsu Yanagimachi, Yukihiko Hiroshima, Junko Takita, Yasuhide Hayashi, Yohei Miyagi   +12 more
wiley   +1 more source

Nucleosome [PDF]

, 2019
openaire   +1 more source

FACT-(H3-H4) complex stimulates Pol α activity to coordinate DNA synthesis with nucleosome assembly. [PDF]

Sci Adv
Zhang W, Geng S, Xu J, Tang Y, Jiao G, Yang J, Shi G, Wu J, Qin F, Gao N, Feng J, Li Q.   +11 more
europepmc   +1 more source

Elucidating the Role of SET as a Key Contributor to Neurodevelopmental Disability Within the 9q34.11 Deletion Syndrome Interval

Clinical Genetics, Volume 110, Issue 4, Page 438-448, October 2026.
This study reports a female proband with a de novo 9q34.11 deletion affecting SET, who underwent a 28‐year diagnostic odyssey after an atypical Rett syndrome clinical diagnosis. Genomic and proteomics analyses confirmed SET haploinsufficiency, refining the critical 9q34.11 region, and supporting speech therapy benefits in improving meaningful ...
Angelo Condell, Elaine Zhang, Tim Sikora, Sean Massey, Nicole J. Van Bergen, Min Wang, Cas Simons, Katrina M. Bell, Daniella H. Hock, David A. Stroud, David Francis, Wendy A. Gold, Martin B. Delatycki, John Christodoulou, Simranpreet Kaur   +14 more
wiley   +1 more source

Multi-omic cell free DNA profiles of cerebral spinal fluid from lung cancer metastasis to the brain. [PDF]

NAR Cancer
Chen T, Bai X, Burnside G, Trinh TTH, Gephart MH, Ji HP, Lau BT.   +6 more
europepmc   +1 more source

KU80 suppresses endonuclease G activity to preserve genomic integrity

The FEBS Journal, Volume 293, Issue 19, Page 5952-5966, October 2026.
Under normal conditions, EndoG remains restricted to mitochondria and the genome remains intact. When KU80 is absent, EndoG translocates into the nucleus, where it promotes DNA fragmentation and genomic instability. Thus, this work highlights the importance of KU80 in tightly controlling EndoG localization to preserve genome stability.
Jargalan Batsaikhan, Kwang‐Hyun Park, Hae Ryung Chang, Eunyoung Jung, Myung‐Jin Kim, Jeeyoon Kang, Hyunjo Shim, Eui‐Jeon Woo, Yonghwan Kim   +8 more
wiley   +1 more source

Cnp1 N-terminal dynamics regulate L1 loop recognition by Mis15 to orchestrate kinetochore assembly in Schizosaccharomyces pombe. [PDF]

J Mol Cell Biol
Xiong Y, Jian Y, Zhang Y, Zhang M, Zhang X, Zhang K, Fu C, Tian T, Zang J.   +8 more
europepmc   +1 more source

Spatially resolved mapping of histones reveals selective neuronal response in Rett syndrome

The FEBS Journal, Volume 293, Issue 19, Page 5814-5836, October 2026.
Rett syndrome (RTT) is a severe neurological disorder caused by loss‐of‐function mutations in the X‐linked MECP2 gene that causes profound life‐long neurological dysfunction. MeCP2 regulates chromatin, yet its influence on histone composition and dynamics is unclear.
Frederike Schäfer, Giuseppina De Rocco, Moritz Völker‐Albert, Ignasi Forne, Nicoletta Landsberger, Axel Imhof, Shibojyoti Lahiri   +6 more
wiley   +1 more source

Poly(ADP-Ribose) polymerase1 Has Potential to Facilitate the Nucleosome Disassembly. [PDF]

Int J Mol Sci
Alekseev AA, Kutuzov MM, Belousova EA, Ukraintsev AA, Goncharov ID, Vasileva AA, Khodorkovskii MA, Lavrik OI.   +7 more
europepmc   +1 more source