Results 171 to 180 of about 75,018 (265)

Structural mechanism of histone H2A.Z exchange by human SRCAP-CFDP1 holoenzyme. [PDF]

Sci Adv
Park G, Wu C, Louder RK.
europepmc   +1 more source

Clinical Epigenomics in Rare Diseases: Interpreting DNA Methylation Episignatures

Molecular Genetics &Genomic Medicine, Volume 14, Issue 10, October 2026.
Clinical epigenomics extends rare‐disease diagnostics beyond DNA sequence by revealing the downstream regulatory consequences of genetic variation. DNA methylation episignatures provide functional evidence that can support diagnosis, refine variant interpretation, distinguish overlapping disorders, and complement genomic, and multi‐omic testing ...
Himanshu Goel, Shuxiang Goh, Luke Stuart
wiley   +1 more source

Integrating the MARTINI2 coarse‐grained force field into HADDOCK3 for faster modeling of large biomolecular complexes

Protein Science, Volume 35, Issue 10, October 2026.
Abstract The integration of coarse‐grained (CG) approaches into docking workflows offers a powerful strategy for modeling large biomolecular assemblies with reduced computational costs. We present here the implementation of the MARTINI2 CG force field into the HADDOCK3 integrative modeling platform.
Raphaelle Versini, Victor Reys, Anna Kravchenko, Rodrigo V. Honorato, Alexandre M. J. J. Bonvin   +4 more
wiley   +1 more source

Cross-Scale Convergence in Epigenetic Gene Regulation: A Perspective on Functional Enrichment Analytics for Cancer. [PDF]

Curr Issues Mol Biol
Marsh AG, Doane AS.
europepmc   +1 more source

Position Effect Variegation of Penicillium rubens Genome and Application in Heterologous Production of the Plant‐Derived Anthraquinone Physcion

Microbial Biotechnology, Volume 19, Issue 10, October 2026.
This study constructed a PiggyBac transposon mediated mutagenesis system which was used to investigate the genomic position effect on heterologous production of physcion in Penicillium ruben. This PB platform enables efficient genetic engineering for secondary metabolite production. ABSTRACT The filamentous fungus Penicillium rubens is well known as an
Meng Wu, Yushi Fu, Linqin Tang, Yongpeng Yao, Yuanyuan Pan, Gang Liu   +5 more
wiley   +1 more source

Nucleosome [PDF]

, 2020
openaire   +1 more source

Dual Roads of CENP-A for Centromere Identification. [PDF]

Bioessays
Hori T, Fukagawa T.
europepmc   +1 more source

Multimodal Ageing Biomarkers and Plasma Proteomic Signatures Associated With All‐Cause Mortality

Aging Cell, Volume 25, Issue 10, October 2026.
We benchmarked 23 ageing biomarkers and 9703 protein targets for associations with mortality risk. Epigenetic, neuroimaging and functional biomarkers showed the strongest associations, outperforming proteomic organ clocks. Among 368 mortality‐associated proteins, high‐risk proteins were enriched in immune functions, whereas low‐risk proteins were ...
Maira Pyrgioti, Ines Mesa Eguiagaray, Paul Redmond, Janie Corley, Mark E. Bastin, Maria Valdés Hernández, Tom C. Russ, Joanna M. Wardlaw, Eilis Hannon, Ian J. Deary, Keenan A. Walker, Elliot M. Tucker‐Drob, Simon R. Cox, Riccardo E. Marioni, Sarah E. Harris   +14 more
wiley   +1 more source

Structural basis of nucleosome remodeling by Cockayne syndrome B homologue Komagataella phaffii Rad26. [PDF]

Nat Commun
Fukushima Y, Kinoshita C, Negishi L, Kujirai T, Kobayashi Y, Ogasawara M, Ehara H, Sekine SI, Kagawa W, Kurumizaka H, Takizawa Y.   +10 more
europepmc   +1 more source

Chromodomain Helicase DNA–Binding Proteins and Spermatogenesis: Current Advances

Andrology, Volume 14, Issue 7, Page 1962-1970, October 2026.
ABSTRACT Background Male infertility is a prevalent clinical condition, with approximately one‐third of cases classified as idiopathic, frequently stemming from impaired spermatogenesis because of dysregulated gene expression. Chromodomain helicase DNA‐binding (CHD) proteins are central chromatin remodelers that orchestrate this epigenetic regulation ...
Mingrui Zhang, Di Liu, Guoqiang Liu, Minggang Zhu, Feng Pan   +4 more
wiley   +1 more source