Results 151 to 160 of about 75,018 (265)

Structural principles underlying the evolution of SWI/SNF chromatin remodelers. [PDF]

Sci Adv
Ma S, Liu M, Xu W, Wang Q, Wang X, Huang Y, Li M, Li C, Shen QT, Chen Y.   +9 more
europepmc   +1 more source

SOX5 Orchestrates Malignant Evolution via Promoter‐Centric Chromatin Remodeling in MYC‐Driven B‐Cell Lymphoma

Advanced Science, Volume 13, Issue 57, 14 October 2026.
In MYC‐enforced B‐cell lymphoma, SOX5 occupies promoter‐proximal regulatory regions and is associated with reduced chromatin accessibility at the PCNP locus. PCNP repression promotes proliferative remodeling by limiting apoptosis and cell‐cycle restraint.
Yiyou Mao, Zhenyuan Jia, Xiao‐Qin Mu, Ruilin Wang, Jianli Ma, Qingyuan Zhang, Yuwei Deng   +6 more
wiley   +1 more source

BRD4 binds the nucleosome via both histone and DNA interactions. [PDF]

Mol Cell
Zhu J, Leith EM, O'Donnell EN, Manzano BP, Wu SY, Chiang CM, Armache JP, Tan S.   +7 more
europepmc   +1 more source

Weighted Single‐Step GWAS Reveals Genetic Mechanisms Underlying Pregnancy Loss in Early Nellore Heifers

Animal Genetics, Volume 57, Issue 5, October 2026.
ABSTRACT Pregnancy loss (PL) affects reproductive efficiency in beef cattle, yet its genetic architecture remains poorly understood in Bos indicus populations. Here, PL was defined as failure from pregnancy diagnosis to calving, capturing a window approximately 60 days after the breeding season.
Flávia C. Bis, Nedenia Bonvino Stafuzza, Elisângela Chicaroni de Mattos, Angélica Simone Cravo Pereira, José Bento Sterman Ferraz, Fernando Baldi, Sabrina T. Amorim   +6 more
wiley   +1 more source

Acetylation‐like H2BK109Q attenuates acute brain injury and preserves axon‐myelin integrity after intracerebral hemorrhage

CNS Neuroscience &Therapeutics, Volume 32, Issue 10, October 2026.
After intracerebral hemorrhage, reduced pan‐H2B acetylation is linked to acute brain injury and axon–myelin damage. The acetylation‐mimetic H2BK109Q substitution attenuates injury and preserves axon–myelin integrity. Regional Galc knockdown diminishes this protection, identifying GALC as a primary contributing effector. ABSTRACT Aims Axon–myelin damage
Sinan Jin, Meng Yang, Jincheng Meng, Ziyi Han, Yousef Rastegar‐Kashkooli, Pengtian Lu, Junmin Wang, Jian Wang, He Wu   +8 more
wiley   +1 more source

Deciphering chromatin architecture and dynamics in Plasmodium falciparum using the nucDetective pipeline. [PDF]

PLoS Comput Biol
Holzinger S, Schmutterer L, Rothe VM, Watzlowik MT, Schwartz U, Längst G.   +5 more
europepmc   +1 more source

Optimized Genome‐Wide Profiling of Centromeric Chromatin Complexes by ChIP‐seq

Current Protocols, Volume 6, Issue 10, October 2026.
Abstract Centromeres are specialized chromosomal regions essential for faithful chromosome segregation and genome stability. Their highly repetitive DNA composition and epigenetically defined chromatin state present significant challenges for genome‐wide profiling approaches such as chromatin immunoprecipitation followed by sequencing (ChIP‐seq ...
Alessia Daponte, Rachel Schwope, Caterina Manzari, Lucia Trisolini, Francesca Antonacci, Michele Morgante, Mario Ventura, Glennis A. Logsdon, Claudia R. Catacchio   +8 more
wiley   +1 more source

Structural Characterization of Native RNA Polymerase II Transcription Complexes and Nucleosomes in Drosophila melanogaster. [PDF]

Nat Commun
Venette-Smith NL, Vishwakarma RK, Venkatakrishnan V, Dollinger R, Schultz J, Babitzke P, Anand G, Gilmour DS, Armache JP, Murakami KS.   +9 more
europepmc   +1 more source

Lactate metabolism and protein lactylation in programmed cell death: From novel mechanism to therapeutic strategies in human diseases

Clinical and Translational Medicine, Volume 16, Issue 10, October 2026.
This review highlights protein lactylation as a metabolic‐epigenetic regulator linking lactate reprogramming to programmed cell death. By modulating histone and non‐histone targets, lactylation reshapes cell fate decisions and represents a promising biomarker and therapeutic target in human diseases.
Yue Chen, Xiwen Wang, Xiuping Wang, Na Lin, Wenjie Wang, Ruiqi Fu, Yutong Wu, Yi Liu, Hengwei Liu   +8 more
wiley   +1 more source

Molecular and Proteomic Profiling of Human Cerebral Organoid‑Derived Small Extracellular Vesicles

Developmental Neurobiology, Volume 86, Issue 4, October 2026.
ABSTRACT Organoids are self‐organized, in vitro 3D structures derived from progenitor or pluripotent stem cells. During culture, these tissues secrete small extracellular vesicles (sEVs)—functional bioactive molecules—into their microenvironment. Here, we differentiated iPSC‐derived cerebral organoids (COs) under three culture conditions (static ...
Elifsu Polatlı, Burak Kahveci, Çağla Kiser, Nurhan Özlü, Gökhan Karakülah, Şermin Genç, Sinan Güven   +6 more
wiley   +1 more source