Results 131 to 140 of about 75,018 (265)

Epigenetic Dysregulation of Somatostatin Receptors (SSTR) 1–5 and Therapeutic Implications in Neuroendocrine and Non‐Neuroendocrine Malignancies

International Journal of Cancer, Volume 159, Issue 11, Page 2633-2652, 1 December 2026.
ABSTRACT Somatostatin receptors (SSTR) mediate the antiproliferative, antisecretory, and proapoptotic effects of somatostatin and its synthetic analogs. Their surface expression on neuroendocrine tumor (NET) cells is required for somatostatin analog therapy and radiopharmaceutical therapy (RPT).
Neeraj Kumari, Pablo Hoffmann, Laura Reichl, Maximilian Schmutz, Nina Fischer, Thi Tuong Vi Dang, Fulvia Ferrazzi, Pascal Johann, Michaela Kuhlen, Constantin Lapa, Rainer Claus   +10 more
wiley   +1 more source

Molecular basis of nick ligation in the nucleosome by DNA Ligase IIIα. [PDF]

Nat Commun
Boesch DJ, Martin NI, Kontor CA, Nguyen AG, Tomkinson AE, Van Houten B, Gillet N, Bignon E, Whitaker AM, Weaver TM.   +9 more
europepmc   +1 more source

Genome‐Wide Association Studies of Micro‐and Macro‐Mineral Concentrations in Cultivated, Wild and Native Pea

Legume Science, Volume 8, Issue 4, December 2026.
ABSTRACT Pea (Pisum sativum) is a nutrient‐rich crop that can provide essential nutrients needed for human and animal health. Improving its mineral concentration through genetic selection can enhance its nutritional value and help combat micronutrient deficiencies. This study aimed to investigate the genetic basis of the accumulation of eight minerals (
Maryam Bagheri, Carla S. Santos, Diego Rubiales, Osman Zakaria Wohor, Marta W. Vasconcelos   +4 more
wiley   +1 more source

High-resolution cryoEM of nucleosomes in nuclear extracts of mammalian cells. [PDF]

Biosci Rep
Ker DS, Aboalnaga H, Pellegrini L.
europepmc   +1 more source

Understanding environmental adaptation in intermediate wheatgrass

The Plant Genome, Volume 19, Issue 4, December 2026.
Abstract Intermediate wheatgrass (IWG; Thinopyrum intermedium) is a perennial grain crop that offers many environmental benefits through extensive root systems in addition to food production. IWG's distribution across broad environmental gradients in Eurasia provides a model system for studying climate adaptation genetics essential for developing ...
Elizabeth Campbell‐Strupp, Anna Halpin‐McCormick, Jacob Jungers, Hannah Stoll, Brooke Bernhardt, Michael Kantar, Bryan Runck   +6 more
wiley   +1 more source

Linker Histones: The Multiple Binding Modes of the Enigmatic 5th Histone. [PDF]

Biomolecules
Rugelis NR, Kumar A, Hayes JJ.
europepmc   +1 more source

Identification of MEF2A, MEF2C, and MEF2D interactomes in basal and Fsk‐stimulated mouse MA‐10 Leydig cells

Andrology, Volume 14, Issue 8, Page 2401-2418, November 2026.
Abstract Background Myocyte enhancer factor 2 transcription factors regulate essential transcriptional programs in various cell types. The activity of myocyte enhancer factor 2 factors is modulated through interactions with cofactors, chromatin remodelers, and other regulatory proteins, which are dependent on cell context and physiological state.
Karine de Mattos, Marie‐Pier Scott‐Boyer, Arnaud Droit, Robert S. Viger, Jacques J. Tremblay   +4 more
wiley   +1 more source

Histone deacetylase inhibitors as venetoclax‐sensitising partners in acute myeloid leukaemia: Mechanisms, pharmacology and translational perspectives

British Journal of Pharmacology, Volume 183, Issue 21, Page 6261-6290, November 2026.
Abstract Venetoclax combined with hypomethylating agents has improved treatment for older or unfit patients with acute myeloid leukaemia (AML), but resistance and relapse remain common. This review analyses the rationale for combining venetoclax with inhibitors of histone deacetylase (HDAC).
Jaebok Lee, Marc Diederich
wiley   +1 more source

CAF-1 in Replication and Repair: A Critical Genetic Mediator of Synthesis-Coupled Nucleosome Assembly. [PDF]

Biomolecules
Hall I, Nowoj CA, Dieckman LM.
europepmc   +1 more source

Multiscale physical effects of CpG methylation on DNA mechanics, nucleosome wrapping, and chromatin condensates. [PDF]

EMBO Rep
Daris LJC, Rizvi A, Nawar A, Singh A, Hutchings J, Lamers LA, Montabana EA, Kimanius D, Banerjee PR, Eeftens JM, Sanulli S.   +10 more
europepmc   +1 more source