Results 131 to 140 of about 148,408 (312)
Pioneer Factor-Nucleosome Binding Events during Differentiation Are Motif Encoded.
Molecules and Cells, 2019 Although the in vitro structural and in vivo spatial characteristics of transcription factor (TF) binding are well defined, TF interactions with chromatin and other companion TFs during development are poorly understood.
Michael P. Meers +2 more
semanticscholar +1 more source
International Journal of Cancer, EarlyView.What's New? This study introduces a novel approach for detecting locally advanced esophageal carcinoma using cell‐free DNA (cfDNA) analysis through a highly sensitive fragmentome assay. Unlike traditional sequencing‐based methods that are limited by the absence of specific mutations in esophageal tumors, our method offers an alternative by quantifying ...
Anouchka Modesto +21 more
wiley +1 more source
Structural basis for nucleosome remodeling by the INO80 complex
Nature, 2018 In the eukaryotic nucleus, DNA is packaged in the form of nucleosomes, each of which comprises about 147 base pairs of DNA wrapped around a histone protein octamer.
S. Eustermann +6 more
semanticscholar +1 more source
Epigenetic Regulation in the Pathogenesis of Renal Inflammation: Insights and Therapeutic Potentials
iNew Medicine, EarlyView.ABSTRACT Renal inflammation is a common pathological process in various kidney diseases, often initiated by factors such as toxins, ischemia, or autoimmune reactions. This inflammatory response can result in structural damage and a rapid decline in renal function.
Yu‐Hang Dong +5 more
wiley +1 more source
Interdisciplinary Medicine, EarlyView.SUMOylation, a dynamic post‐translational modification, acts as a master regulator at the heart of tumor malignancy. Our work delineates how the SUMOylation cycle—mediated by E1/E2/E3 enzymes and reversed by SENPs—orchestrates multiple hallmarks of cancer. The central pathway converges on three critical pathological axes: 1.
Yimao Wu +6 more
wiley +1 more source
Journal of the Chinese Chemical Society, EarlyView.Model for how α‐syn modulates the positioning of endolysosomes in melanoma cells. (a) α‐syn tethers endolysosomes to the plasma membrane, a last step in anterograde transport. (b) Loss of α‐syn expression causes the loss of the tethering function, which leads to perinuclear vesicle clustering. Reproduced from the open access article.
Stephan N. Witt
wiley +1 more source
Chromatin Profiles of Chromosomally Integrated Human Herpesvirus-6A [PDF]
, 2019 Human herpesvirus-6A (HHV-6A) and 6B (HHV-6B) are two closely related betaherpesviruses that are associated with various diseases including seizures and encephalitis.
Boyd, Joseph R. +12 more
core +1 more source
Cell, 2019 Chromatin domains and their associated structures must be faithfully inherited through cellular division to maintain cellular identity. However, accessing the localized strategies preserving chromatin domain inheritance, specifically the transfer of ...
Thelma M. Escobar +5 more
semanticscholar +1 more source
Bioanalytical TERS and Advanced Data Processing Methods
Journal of Raman Spectroscopy, EarlyView.Tip‐enhanced Raman spectroscopy delivers label‐free, subnanometer vibrational imaging of biological systems. Recent advances in instrumentation, data analysis, and ambient/liquid operation enable surface‐selective mapping of molecular heterogeneity in proteins, nucleic acids, membranes, and viruses, positioning TERS as a powerful platform for nanoscale
Sarika Joshi +6 more
wiley +1 more source
, 2010 We investigated the effect of torsional rigidity of a semiflexible chain on the wrapping transition around a spherical core, as a model of nucleosome, the fundamental unit of chromatin.
A. Wolffe +5 more
core +1 more source