Results 111 to 120 of about 148,408 (312)

Toward a molecular understanding of yeast silent chromatin : roles for H4K16 acetylation and the Sir3 C-terminus [PDF]

, 2012
Discrete regions of the eukaryotic genome assume a heritable chromatin structure that is refractory to gene expression. In budding yeast, silent chromatin is characterized by the loading of the Silent Information Regulatory (Sir) proteins (Sir2, Sir3 and
Oppikofer, Mariano
core   +1 more source

Structure of SWI/SNF chromatin remodeler RSC bound to a nucleosome

Nature, 2019
Chromatin-remodelling complexes of the SWI/SNF family function in the formation of nucleosome-depleted, transcriptionally active promoter regions (NDRs)1,2.
F. R. Wagner, C. Dienemann, Haibo Wang, A. Stuetzer, D. Tegunov, H. Urlaub, P. Cramer   +6 more
semanticscholar   +1 more source

A Viscous DES‐AAV‐Foxo1 Delivery System With High Transfection Efficiency for the Treatment of Corneal Endothelial Dysfunction by Restoring Mitochondria‐ER Contacts

Advanced Science, EarlyView.
High glucose triggers corneal endothelial dysfunction by impairing FOXO1‐mediated ITPR1 transcription, leading to disrupted mitochondria‐associated membrane (MAM) integrity and defective ER‐to‐mitochondria Ca2+ transfer. This study develops an innovative viscous DES‐AAV‐Foxo1 delivery system with enhanced transfection efficiency. This non‐invasive gene
Hongran Zhao, Xiaoyu Li, Hongwei Wang, Zongyi Li, Qun Wang, Yangyang Zhang, Xu Jing, Xia Qi, Qingjun Zhou, Shengqian Dou, Lixin Xie   +10 more
wiley   +1 more source

Stochastic model for nucleosome sliding in the presence of DNA ligands

, 2008
Heat-induced mobility of nucleosomes along DNA is an experimentally well-studied phenomenon. A recent experiment shows that the repositioning is modified in the presence of minor-groove binding DNA ligands.
B. ten Heggeler-Bordier, D. Lacoste, F. Mohammad-Rafiee, G. Meersseman, H. Schiessel, J. Deseigne, L. Mollazadeh-Beidokhti, T. H. Cormen   +7 more
core   +1 more source

Nucleosomes in serum of patients with early cerebral stroke [PDF]

, 2006
Background: Nucleosomes are cell death products that are elevated in serum of patients with diseases that are associated with massive cell destruction.
Adams, Boysen G, Chan KC, Di Napoli M, Dietrich Seidel, Dorothea Nagel, Gerhard F. Hamann, Holdenrieder S, Jun Ma, Katsura K, Lichtenstein AV, Lo YMD, Lo YMD, Mahoney FI, Missler U, Muir KW, Petra Stieber, Roland Bruening, Rumore PM, Sandra Geiger, Stefan Holdenrieder, van Everdingen KJ, Wunderlich MT   +22 more
core   +1 more source

Sub-nucleosomal Genome Structure Reveals Distinct Nucleosome Folding Motifs.

Cell, 2019
Elucidating the global and local rules that govern genome-wide, hierarchical chromatin architecture remains a critical challenge. Current high-throughput chromosome conformation capture (Hi-C) technologies have identified large-scale chromatin structural
M. Ohno, T. Ando, D. Priest, Vipin Kumar, Y. Yoshida, Y. Taniguchi   +5 more
semanticscholar   +1 more source

Organization of fast and slow chromatin revealed by single-nucleosome dynamics [PDF]

Proceedings of the National Academy of Sciences of the United States of America, 2019
Significance Recent live cell imaging has revealed that chromatin is not a static, rigid structure but is dynamically fluctuating in cells. We study chromatin motion by using single-nucleosome tracking data in living human cells.
S. S. Ashwin, T. Nozaki, K. Maeshima, M. Sasai   +3 more
semanticscholar   +1 more source

Dissecting Pirtobrutinib Resistance in Mantle Cell Lymphoma Through Single‐Cell Multi‐Omics

American Journal of Hematology, EarlyView.
ABSTRACT Pirtobrutinib (PBN), a non‐covalent BTK inhibitor, has been approved by the FDA for relapsed/refractory mantle cell lymphoma (MCL); however, resistance to PBN has been observed. To dissect the molecular dynamics driving PBN resistance, we performed integrative single‐cell multi‐omic profiling (scRNA‐seq, scATAC‐seq, and scDNA‐seq) on ...
Fangfang Yan, Yang Liu, Heng‐Huan Lee, Wei Wang, Joseph McIntosh, Yijing Li, Jovanny Vargas, Yue Fei, Sairah Ahmed, Lukas M. Simon, Michael Wang   +10 more
wiley   +1 more source

Defining transcription factor nucleosome binding with Pioneer-seq.

PLoS Genetics
Gene expression requires the targeting of transcription factors (TFs) to regulatory sequences often occluded within nucleosomes. To comprehensively examine TF nucleosome binding, we developed Pioneer-Seq.
Maria Tsompana, Patrick D Wilson, Vijaya Murugaiyan, Christopher R Handelmann, Michael J Buck   +4 more
doaj   +1 more source

Insights into distinct regulatory modes of nucleosome positioning

BMC Genomics, 2009
Background The nucleosome is the fundamental unit of eukaryotic genomes. Experimental evidence suggests that the genomic DNA sequence and a variety of protein factors contribute to nucleosome positioning in vivo.
Feng Jihua, Xiang Qian, Dai Xianhua, Dai Zhiming, Deng Yangyang, Wang Jiang   +5 more
doaj   +1 more source