Results 101 to 110 of about 148,408 (312)
Cell cycle-specified fluctuation of nucleosome occupancy at gene promoters.
PLoS Genetics, 2006 The packaging of DNA into nucleosomes influences the accessibility of underlying regulatory information. Nucleosome occupancy and positioning are best characterized in the budding yeast Saccharomyces cerevisiae, albeit in asynchronous cell populations or
Gregory J Hogan +2 more
doaj +1 more source
Diversity of eukaryotic DNA replication origins revealed by genome-wide analysis of chromatin structure. [PDF]
PLoS Genetics, 2010 Eukaryotic DNA replication origins differ both in their efficiency and in the characteristic time during S phase when they become active. The biological basis for these differences remains unknown, but they could be a consequence of chromatin structure ...
Nicolas M Berbenetz +2 more
doaj +1 more source
Conserved noncoding sequences highlight shared components of regulatory networks in dicotyledonous plants [PDF]
, 2012 Conserved noncoding sequences (CNSs) in DNA are reliable pointers to regulatory elements controlling gene expression. Using a comparative genomics approach with four dicotyledonous plant species (Arabidopsis thaliana, papaya [Carica papaya], poplar ...
Barrington, Christopher +11 more
core +2 more sources
Contributions of histone variants in nucleosome structure and function.
Journal of Molecular Biology, 2020 Chromatin compacts genomic DNA in eukaryotes. The primary chromatin unit is the nucleosome core particle, composed of four pairs of the core histones, H2A, H2B, H3, and H4, and 145-147 base pairs of DNA.
H. Kurumizaka, T. Kujirai, Y. Takizawa
semanticscholar +1 more source
Asymmetrically Modified Nucleosomes [PDF]
Cell, 2012 Mononucleosomes, the basic building blocks of chromatin, contain two copies of each core histone. The associated posttranslational modifications regulate essential chromatin-dependent processes, yet whether each histone copy is identically modified in vivo is unclear.
Voigt, Philipp +8 more
openaire +2 more sources
Sono‐Mechanogenetics: Linking Ultrasound Physics With Cellular Mechanobiology
Advanced Science, EarlyView.Sono‐mechanogenetics links ultrasound physics with cellular mechanotransduction to enable noninvasive control of engineered biological systems. Acoustic forces generate distinct deformation modes that activate intracellular signaling pathways, which can be coupled to synthetic gene circuits to regulate diverse cellular functions, including gene ...
Yunjia Qu +4 more
wiley +1 more source
NAP1-assisted nucleosome assembly on DNA measured in real time by single-molecule magnetic tweezers.
PLoS ONE, 2012 While many proteins are involved in the assembly and (re)positioning of nucleosomes, the dynamics of protein-assisted nucleosome formation are not well understood.
Rifka Vlijm +3 more
doaj +1 more source
Advanced Science, EarlyView.Engineered extracellular vesicles displaying Ephrin‐B2 selectively target Ephrin‐B4–expressing ovarian cancer cells, enabling precise delivery in patient‐derived models. This scalable bio‐manufacturing platform reveals a versatile strategy to exploit Ephrin signaling for highly specific therapeutic payload delivery and motivates exploration of tailored
Nihar Godbole +17 more
wiley +1 more source
Distinct modes of regulation by chromatin encoded through nucleosome positioning signals.
PLoS Computational Biology, 2008 The detailed positions of nucleosomes profoundly impact gene regulation and are partly encoded by the genomic DNA sequence. However, less is known about the functional consequences of this encoding.
Yair Field +7 more
doaj +1 more source
HP1 reshapes nucleosome core to promote phase separation of heterochromatin [PDF]
, 2019 Heterochromatin affects genome function at many levels. It enables heritable gene repression, maintains chromosome integrity and provides mechanical rigidity to the nucleus1,2.
Burlingame, AL +8 more
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