Results 291 to 300 of about 80,558 (329)

CTCF binding landscape is shaped by the epigenetic state of the N-terminal nucleosome in relation to CTCF motif orientation. [PDF]

Nucleic Acids Res
Tajmul M, Bhatt DN, Ruje L, Price E, Ji Y, Loukinov D, Teif VB, Lobanenkov VV, Pugacheva EM.   +8 more
europepmc   +1 more source

Management of T‐cell malignancies: Bench‐to‐bedside targeting of epigenetic biology

CA: A Cancer Journal for Clinicians, Volume 75, Issue 4, Page 282-307, July/August 2025.
Abstract The peripheral T‐cell lymphomas (PTCL) are the only disease for which four histone deacetylase (HDAC) inhibitors have been approved globally as single agents. Although it is not clear why the PTCL exhibit such a vulnerability to these drugs, understanding the biological basis for this activity is essential.
Ariana Sabzevari, Johnson Ung, Jeffrey W. Craig, Kallesh D. Jayappa, Ipsita Pal, David J. Feith, Thomas P. Loughran Jr, Owen A. O’Connor   +7 more
wiley   +1 more source

A Method for Constructing Nucleosome Arrays with Spatially Defined Histone PTMs and DNA Damage. [PDF]

Angew Chem Int Ed Engl
Liu Z, Xi S, McGregor LA, Yamatsugu K, Kawashima SA, Sczepanski JT, Kanai M.   +6 more
europepmc   +1 more source

HR‐MS Analysis of the Covalent Binding of Edaravone to 5‐Formylpyrimidine Bases and a DNA Oligonucleotide Containing a 5‐Formylcytidine Residue

Rapid Communications in Mass Spectrometry, Volume 39, Issue 14, 30 July 2025.
ABSTRACT Rationale Edaravone (EDA) is a radical scavenger and an antioxidant drug approved to treat amyotrophic lateral sclerosis and used as a research tool to explore treatment of neurodegenerative diseases and cancers. It is also a reactive agent, known as PMP (1‐phenyl‐3‐methyl‐5‐pyrazolone), used for the analysis of polysaccharides composition ...
Romain Regnault, Mostafa Kouach, Laurence Goossens, Xavier Thuru, Christian Bailly, Jean‐François Goossens   +5 more
wiley   +1 more source

Nanoscale analysis of human G1 and metaphase chromatin in situ. [PDF]

EMBO J
Chen JK, Liu T, Cai S, Ruan W, Ng CT, Shi J, Surana U, Gan L.   +7 more
europepmc   +1 more source

Replication-dependent histone labeling dissects the physical properties of euchromatin/heterochromatin in living human cells. [PDF]

Sci Adv
Minami K, Nakazato K, Ide S, Kaizu K, Higashi K, Tamura S, Toyoda A, Takahashi K, Kurokawa K, Maeshima K.   +9 more
europepmc   +1 more source

Centromeres drive and take a break. [PDF]

Chromosome Res
Talbert PB, Henikoff S.
europepmc   +1 more source

MagIC-Cryo-EM, structural determination on magnetic beads for scarce macromolecules in heterogeneous samples. [PDF]

Elife
Arimura Y, Konishi HA, Funabiki H.
europepmc   +1 more source

Start, stop, resume, and proceed: ZmSSRP1 mediates the progression of RNA polymerase II and kernel development in maize. [PDF]

Plant Cell
Lorenzo CD.
europepmc   +1 more source

Nucleosome dynamics render heterochromatin accessible in living human cells. [PDF]

Nat Commun
Prajapati HK, Xu Z, Eriksson PR, Clark DJ.   +3 more
europepmc   +1 more source