Results 111 to 120 of about 1,684,114 (372)
Molecular Oncology, EarlyView.Low expression of five purine metabolism‐related genes (ADSL, APRT, ADCY3, NME3, NME6) was correlated with poor survival in colorectal cancer. Immunohistochemistry analysis showed that low NME3 (early stage) and low ADSL/NME6 (late stage) levels were associated with high risk.
Sungyeon Kim +8 more
wiley +1 more source
Nucleotide-induced conformational motions and transmembrane gating dynamics in a bacterial ABC transporter [PDF]
arXiv, 2014 ATP-binding cassette (ABC) transporters are integral membrane proteins that mediate the exchange of diverse substrates across membranes powered by ATP hydrolysis. We report results of coarse-grained dynamical simulations performed for the bacterial heme transporter HmuUV.
arxiv
A model for nucleotide sequences
Biophysical Journal, 1995 We propose a model for generating "artificial" nucleotide sequences and, by the method of mapping those sequences onto a "DNA-walk," we analyze the presence of correlation between nucleotides. Artificial sequences are constructed considering, basically, interactions between first neighbors and between more distant units.
Celia Anteneodo, A. M. C. De Souza
openaire +3 more sources
Identification of cancer driver genes based on nucleotide context
Nature Genetics, 2019 Cancer genomes contain large numbers of somatic mutations but few of these mutations drive tumor development. Current approaches either identify driver genes on the basis of mutational recurrence or approximate the functional consequences of ...
Felix Dietlein +8 more
semanticscholar +1 more source
Molecular Oncology, EarlyView.Combining melting curve analysis enhances the multiplexing capability of digital PCR. Here, we developed a 14‐plex assay to simultaneously measure single nucleotide mutations and amplifications of KRAS and GNAS, which are common driver genes in pancreatic cancer precursors. This assay accurately quantified variant allele frequencies in clinical samples
Junko Tanaka +10 more
wiley +1 more source
Regulation of mammalian nucleotide metabolism and biosynthesis
Nucleic Acids Research, 2015 Nucleotides are required for a wide variety of biological processes and are constantly synthesized denovo in all cells. When cells proliferate, increased nucleotide synthesis is necessary for DNA replication and for RNA production to support protein ...
A. Lane, T. Fan
semanticscholar +1 more source
Molecular Oncology, EarlyView.Loss of the frequently mutated chromatin remodeler ARID1A, a subunit of the SWI/SNF cBAF complex, results in less open chromatin, alternative splicing, and the failure to stop cells from progressing through the cell cycle after DNA damage in bladder (cancer) cells. Created in BioRender. Epigenetic regulators, such as the SWI/SNF complex, with important
Rebecca M. Schlösser +11 more
wiley +1 more source
Relative Impact of Nucleotide and Copy Number Variation on Gene Expression Phenotypes
Science, 2007 Extensive studies are currently being performed to associate disease susceptibility with one form of genetic variation, namely, single-nucleotide polymorphisms (SNPs).
B. Stranger +16 more
semanticscholar +1 more source
Germline variants in CDKN2A wild‐type melanoma prone families
Molecular Oncology, EarlyView.Among melanoma‐prone families, wild‐type for CDKN2A and CDK4, some have pathogenic variants in genes not usually linked to melanoma. Furthermore, rare XP‐related variants and variants in MC1R are enriched in such families. Germline pathogenic variants in CDKN2A are well established as an underlying cause of familial malignant melanoma. While pathogenic
Gjertrud T. Iversen +5 more
wiley +1 more source
Journal of Dairy Science, 2022 : A robust method using HPLC-UV was developed to improve the accuracy and repeatability of a quantitative method to detect 5 nucleotides (cytidine-monophosphate, uridine monophosphate, adenosine monophosphate, guanine monophosphate, and inosine ...
Yuanjia Chen +4 more
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