Results 11 to 20 of about 670,950 (297)

Nucleotide Excision Repair

open access: yesDefinitions, 2020
European Bioinformatics Institute, New York University Langone Medical Center, Ontario Institute for Cancer Research, Oregon Health and Science University.
W. Mcgregor
semanticscholar   +3 more sources

The Intersection of Purine and Mitochondrial Metabolism in Cancer

open access: yesCells, 2021
Nucleotides are essential to cell growth and survival, providing cells with building blocks for DNA and RNA, energy carriers, and cofactors. Mitochondria have a critical role in the production of intracellular ATP and participate in the generation of ...
Humberto De Vitto   +3 more
doaj   +1 more source

Molecular analysis of ompA gene Pasteurella multocida Indonesia local isolates [PDF]

open access: yesIraqi Journal of Veterinary Sciences, 2020
The aim of this research was to analyze ompA molecular gene of Pasteurella multocida buffalo isolate and bovine isolate from Nusa Tenggara Timur, Indonesia and Katha strain isolate from hemorrhagic septicemia vaccine. Determinant of P.
A. T. Soelih Estoepangestie   +5 more
doaj   +1 more source

Minimap2: pairwise alignment for nucleotide sequences [PDF]

open access: yesBioinform., 2017
Motivation Recent advances in sequencing technologies promise ultra-long reads of ∼100 kb in average, full-length mRNA or cDNA reads in high throughput and genomic contigs over 100 Mb in length.
Heng Li
semanticscholar   +1 more source

Nucleotides Entrapped in Liposome Nanovesicles as Tools for Therapeutic and Diagnostic Use in Biomedical Applications

open access: yesPharmaceutics, 2023
The use of nucleotides for biomedical applications is an old desire in the scientific community. As we will present here, there are references published over the past 40 years with this intended use.
Camila Magalhães Cardador   +7 more
doaj   +1 more source

Nucleotide metabolism: a pan-cancer metabolic dependency

open access: yesNature Reviews. Cancer, 2023
Overactive nucleotide synthesis is a hallmark of cancers and inhibitors of nucleotide synthesis pathways have shown promise in some cancer types. In this Review, Mullen and Singh give an overview of the role of aberrant nucleotide synthesis in supporting
Nick Mullen, Pankaj Singh
semanticscholar   +1 more source

A nuclear orthologue of the dNTP triphosphohydrolase SAMHD1 controls dNTP homeostasis and genomic stability in Trypanosoma brucei

open access: yesFrontiers in Cellular and Infection Microbiology, 2023
Maintenance of dNTPs pools in Trypanosoma brucei is dependent on both biosynthetic and degradation pathways that together ensure correct cellular homeostasis throughout the cell cycle which is essential for the preservation of genomic stability. Both the
Pablo Antequera-Parrilla   +4 more
doaj   +1 more source

Stimuli-Responsive Nucleotide–Amino Acid Hybrid Supramolecular Hydrogels

open access: yesGels, 2021
The ability to assemble chemically different gelator molecules into complex supramolecular hydrogels provides excellent opportunities to construct functional soft materials.
Matthew Mulvee   +3 more
doaj   +1 more source

Dose-Dependent Von Willebrand Factor Inhibition by Aptamer BB-031 Correlates with Thrombolysis in a Microfluidic Model of Arterial Occlusion

open access: yesPharmaceuticals, 2022
Von Willebrand Factor (VWF) plays a critical role in thrombus formation, stabilization, and propagation. Previous studies have demonstrated that targeted inhibition of VWF induces thrombolysis when administered in vivo in animal models of ischemic stroke.
Susan M. Shea   +7 more
doaj   +1 more source

Evolutionary degeneration of septins into pseudoGTPases: impacts on a hetero-oligomeric assembly interface

open access: yesFrontiers in Cell and Developmental Biology, 2023
The septin family of eukaryotic proteins comprises distinct classes of sequence-related monomers that associate in a defined order into linear hetero-oligomers, which are capable of polymerizing into cytoskeletal filaments. Like actin and ⍺ and β tubulin,
Alya Hussain   +3 more
doaj   +1 more source

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