Results 11 to 20 of about 2,512,035 (335)
HyenaDNA: Long-Range Genomic Sequence Modeling at Single Nucleotide Resolution [PDF]
Neural Information Processing Systems, 2023 Genomic (DNA) sequences encode an enormous amount of information for gene regulation and protein synthesis. Similar to natural language models, researchers have proposed foundation models in genomics to learn generalizable features from unlabeled genome ...
Eric D Nguyen +12 more
semanticscholar +1 more source
Nucleotide metabolism: a pan-cancer metabolic dependency
Nature Reviews. Cancer, 2023 Overactive nucleotide synthesis is a hallmark of cancers and inhibitors of nucleotide synthesis pathways have shown promise in some cancer types. In this Review, Mullen and Singh give an overview of the role of aberrant nucleotide synthesis in supporting
Nick Mullen, Pankaj Singh
semanticscholar +1 more source
Angewandte Chemie International Edition, 2011 DNA as an information storage system is simple and at the same time complex owing to the various different arrangements of the four natural nucleotides.[1] The DNA synthesis by DNA polymerases is intriguing, since these enzymes are able to catalyze the elongation of the primer strand by recognizing the DNA template and selecting the corresponding ...
Baccaro, Anna +2 more
openaire +3 more sources
Nucleotide-decorated AuNPs as probes for nucleotide-binding proteins [PDF]
Scientific Reports, 2021 AbstractGold nanoparticles (AuNPs) decorated with biologically relevant molecules have variety of applications in optical sensing of bioanalytes. Coating AuNPs with small nucleotides produces particles with high stability in water, but functionality-compatible strategies are needed to uncover the full potential of this type of conjugates.
Maciej Mazur +7 more
openaire +3 more sources
Periodic correlation structures in bacterial and archaeal complete genomes [PDF]
, 2013 The periodic transference of nucleotide strings in bacterial and archaeal complete genomes is investigated by using the metric representation and the recurrence plot method.
Wu, Zuo-Bing
core +1 more source
Cofactor regeneration by a soluble pyridine nucleotide transhydrogenase for biological production of hydromorphone [PDF]
, 2000 We have applied the soluble pyridine nucleotide transhydrogenase of Pseudomonas fluorescens to a cell-free system for the regeneration of the nicotinamide cofactors NAD and NADP in the biological production of the important semisynthetic opiate drug ...
Boonstra, B +4 more
core +2 more sources
Nucleotide Frequencies in Human Genome and Fibonacci Numbers [PDF]
, 2006 This work presents a mathematical model that establishes an interesting connection between nucleotide frequencies in human single-stranded DNA and the famous Fibonacci's numbers. The model relies on two assumptions.
A. Dress +14 more
core +2 more sources
Targeting nucleotide metabolism: a promising approach to enhance cancer immunotherapy
Journal of Hematology & Oncology, 2022 Targeting nucleotide metabolism can not only inhibit tumor initiation and progression but also exert serious side effects. With in-depth studies of nucleotide metabolism, our understanding of nucleotide metabolism in tumors has revealed their non ...
Huai-liang Wu +5 more
semanticscholar +1 more source
Gastroprotective effects of oral nucleotide administration [PDF]
, 2006 BACKGROUND AND AIMS: Nucleotides form the building blocks of DNA and are marketed as dietary supplements, alone or in combination with other ingredients, to promote general health.
Belo, A +4 more
core +2 more sources
Genetic variability of Taenia saginata inferred from mitochondrial DNA sequences [PDF]
, 2015 Taenia saginata is an important tapeworm, infecting humans in many parts of the world. The present study was undertaken to identify inter- and intraspecific variation of T.
Babaei, Z. +5 more
core +1 more source