Results 301 to 310 of about 1,684,114 (372)

The Super Enhancer‐Driven Long Noncoding RNA PRKCQ‐AS1 Promotes Neuroblastoma Tumorigenesis by Interacting With MSI2 Protein and Is Targetable by Small Molecule Compounds

Advanced Science, EarlyView.
PRKCQ‐AS1 is overexpressed due to transcriptional super‐enhancers. PRKCQ‐AS1 RNA forms a complex with MSI2 protein to induce BMX mRNA stabilization and overexpression, ERK protein phosphorylation and neuroblastoma cell proliferation. Compound NSC617570 blocks PRKCQ‐AS1 binding to MSI2, leading to BMX mRNA disassociation from MSI2 protein, BMX reduction,
Sujanna Mondal, Pei Y. Liu, Janith Seneviratne, Antoine De Weck, Pooja Venkat, Chelsea Mayoh, Jing Wu, Jesper Maag, Jingwei Chen, Matthew Wong, Nenad Bartonicek, Poh Khoo, Lei Jin, Louise E. Ludlow, David S. Ziegler, Toby Trahair, Pieter Mestdagh, Belamy B. Cheung, Jinyan Li, Marcel E. Dinger, Ian Street, Xu D. Zhang, Glenn M. Marshall, Tao Liu   +23 more
wiley   +1 more source

High-resolution structures of Myosin-IC reveal a unique actin-binding orientation, ADP release pathway, and power stroke trajectory. [PDF]

Proc Natl Acad Sci U S A
Chavali SS, Carman PJ, Shuman H, Ostap EM, Sindelar CV.   +4 more
europepmc   +1 more source

Integrative Multi‐Omics and Routine Blood Analysis Using Deep Learning: Cost‐Effective Early Prediction of Chronic Disease Risks

Advanced Science, EarlyView.
Omicsformer, a deep learning model, integrates multi‐omics and routine blood data to accurately predict risks for nine chronic diseases, including cancer and cardiovascular conditions. Validated using large scale clinical data, it reveals early risk trajectories, advancing personalized medicine and offering a cost‐effective, community‐based solution ...
Zhibin Dong, Pei Li, Yi Jiang, Zhihan Wang, Shihui Fu, Hebin Che, Meng Liu, Xiaojing Zhao, Chunlei Liu, Chenghui Zhao, Qin Zhong, Chongyou Rao, Siwei Wang, Suyuan Liu, Dayu Hu, Dongjin Wang, Juntao Gao, Kai Guo, Xinwang Liu, En Zhu, Kunlun He   +20 more
wiley   +1 more source

SGV-caller: SARS-CoV-2 genome variation caller. [PDF]

Heliyon
Wu J, Kryukov K, Takeuchi JS, Nakagawa S.   +3 more
europepmc   +1 more source

Enhancing Osteogenesis through Bio‐Inspired Recombinant Coral Protein Galaxin by Targeting Mitochondrial Metabolism and ATP Production

Advanced Science, EarlyView.
The study highlights the potential of recombinant galaxin (a coral protein) as a novel and effective biomaterial for bone regeneration. It binds to ATP synthase subunit β (ATP5B) in mouse pre‐osteoblasts, thereby causing increased ATP production and mitochondrial activity.
Fei Yu, Xing Zhao, Ting Jiang, Ningjuan Ouyang, Peilin Li, Wei Yang, Zhihe Zhao   +6 more
wiley   +1 more source

HPF1 Regulates Pol β Efficiency in Nucleosomes via the Modulation of Total Poly(ADP-Ribose) Synthesis. [PDF]

Int J Mol Sci
Kutuzov M, Sayfullina D, Belousova E, Lavrik O.   +3 more
europepmc   +1 more source

Dissecting the Spatial and Single‐Cell Transcriptomic Architecture of Cancer Stem Cell Niche Driving Tumor Progression in Gastric Cancer

Advanced Science, EarlyView.
A single‐cell and spatial transcriptional atlas reveals the architecture of human gastric cancer stem cell (CSC) niche and the developmental trajectory of CSCs. These CSCs interact with immunosuppressive immune cells thereby constructing immune‐suppressive niche, and inflammatory cancer‐associated fibroblast (iCAFs) to enhance stemness through ...
Guangyu Zhang, Xin Zhang, Wenting Pan, Xizhao Chen, Lingfei Wan, Chunjie Liu, Yuting Yong, Yue Zhao, Shuli Sang, Lihua Zhang, Sheng Yao, Yushu Guo, Mingmei Wang, Xinhui Wang, Guangdun Peng, Xinlong Yan, Yanchun Wang, Min Zhang   +17 more
wiley   +1 more source

Genetic variations and carcinogenicity analysis of E6/E7 oncogenes in HPV31 and HPV35 in Taizhou, China. [PDF]

Virol J
Yuan HB, Yu JH, Gan J, Qiu Y, Yan ZY, Xu HH.   +5 more
europepmc   +1 more source

Genomic Insights into Post‐Domestication Expansion and Selection of Body Size in Ponies

Advanced Science, EarlyView.
The authors’ research delves into the history of ponies by assembling a pony genome and integrating horse genomes. This unveils genetic connections between Asian and European pony breeds. Cis‐regulatory elements of key genes impacting body size are also identified.
Xingzheng Li, Zihao Wang, Min Zhu, Binhu Wang, Shaohua Teng, Jing Yan, Haoyu Wang, Pengxiang Yuan, Shuwei Cao, Xiaolu Qu, Zhen Wang, Kai Zhan, Md. Panir Choudhury, Xintong Yang, Qi Bao, Sang He, Lei Liu, Pengju Zhao, Jicai Jiang, Hai Xiang, Lingzhao Fang, Zhonglin Tang, Yuying Liao, Guoqiang Yi   +23 more
wiley   +1 more source

Genome sequence of <i>Bacillus</i> sp. strain BAU-SS-2023, isolated from nasal swab of cattle in Bangladesh. [PDF]

Microbiol Resour Announc
Rahman MA, Alam J, Zereen F, Hossain MG, Saha S.   +4 more
europepmc   +1 more source