Results 321 to 330 of about 2,769,148 (383)

ZNRD2 Mediated Nucleoprotein Aggregation Impairs Respiratory Syncytial Virus Replication

Advanced Science, EarlyView.
During RSV infection, nucleoprotein (N) forms RNA‐bound oligomers. The host protein ZNRD2 binds to these oligomers, promoting their transition into insoluble aggregates. These aggregates simultaneously sequester functional N to restrict viral production and disrupt chaperonin assembly quality control by interfering with ZNRD2's role as an adaptor ...
Haiwu Zhou, Mingbin He, Jinhong Du, Cong Liu, Weiwei Wang, Yuewen Han, Zhifei Li, Yali Qin, Mingzhou Chen   +8 more
wiley   +1 more source

Structural snapshots of the mechanism of ATP-dependent DNA damage recognition by UvrA. [PDF]

Nat Commun
Nirwal S, Czarnocki-Cieciura M, Zajko W, Skowronek K, Szczepanowski RH, Nowotny M.   +5 more
europepmc   +1 more source

Single‐Cell Dissection Reveals Immune Dysregulation After CD5 or CD7‐Directed Chimeric Antigen Receptor T‐Cell Therapy

Advanced Science, EarlyView.
Single‐cell RNA/TCR/BCR sequencing reveals that 5CAR therapy in T‐ALL induces T‐cell exhaustion, reduces EBV‐associated TCRs, lowers TCR/BCR diversity, and increases NK/DC/monocyte activation and function. In contrast, 7CAR therapy reduces multiple pathogen‐associated TCRs, enhances NK cell activation and function, decreases monocyte activation, and ...
Yuechen Luo, Haixiao Zhang, Kaiting Tang, Yiming Wang, Huajiang Dong, Wei Qi, Lingling Shan, Yue Tan, Liping Zhao, Jun Shi, Erlie Jiang, Jing Pan, Xiaoming Feng   +12 more
wiley   +1 more source

Impact of the Warburg effect on nucleotide homeostasis in human retinal endothelial cells and its relevance to proliferative diabetic retinopathy. [PDF]

Front Pharmacol
Gregory A, Awad AM, Eltanani S, Yumnamcha T, Hart J, Me R, Lin X, Shawky M, Ibrahim AS.   +8 more
europepmc   +1 more source

Protein Language Model‐Guided Engineering of a 2,3‐Butanediol Dehydrogenase for the Enantioselective Synthesis of Cyclic α‐Hydroxy Ketones

Advanced Science, EarlyView.
A (2R,3R)‐butanediol dehydrogenase from Bacillus subtilis (BsBDH) is engineered for the enantioselective synthesis of 2‐hydroxycyclohexanone. A PASS computational design strategy is proposed to enhance the thermostability of BsBDH. Moreover, ESM‐1v combined with ISM is utilized for enhancing and inverting its stereoselectivity.
Haote Ding, Ling Jiang, Yijia Song, Zhongji Pu, Lirong Yang, Haoran Yu   +5 more
wiley   +1 more source

PolyA-GLM: A comprehensive framework for <i>De novo</i> polyadenylation site prediction using genome language models. [PDF]

Comput Struct Biotechnol J
Saha S, Fahmi NA, Yong J, Zhang W.
europepmc   +1 more source

Pangenomics in the Mimulus guttatus Species Complex. [PDF]

Mol Ecol Resour
James ME.
europepmc   +1 more source

Polymorphic microsatellite loci from ddRAD sequencing data in different Indian yak populations adapted to diverse climatic conditions. [PDF]

BMC Genomics
Ahmad SF, Chand R, Gangwar M, Rudhreswaran M, Kumar A, Hassan MM, Kumar ST, Kumar P, Kumar A, Dutt T.   +9 more
europepmc   +1 more source

A comprehensive survey of genome language models in bioinformatics. [PDF]

Brief Bioinform
Shu L, Tang J, Guan X, Zhang D.
europepmc   +1 more source