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Nucleotide Sequence

Definitions, 2020
TFe nucleotide sequence of the smaller genomic strand (RNA-2) of the bipartite tobacco rattle virus (CAM strain) has been determined. RNA-2 is capped at the 5' terminus and contains 1799 nucleotide residues.
S. Kowalski, T. Yamane, J. R. Fresco
semanticscholar   +1 more source

Nucleotide receptors

Current Opinion in Neurobiology, 1997
Adenosine 5'-triphosphate (ATP) and/or related nucleotides act at both ionotropic (P2X) and metabotropic (P2Y) receptors. P2X receptor subunits (P2X1-P2X7) form ligand-gated cation channels, as homomultimers or heteromultimers. Recent work indicates that P2X3 subunits participate in channels expressed by nociceptive sensory neurons, and that the second
Barnard, EA, North, RA
openaire   +3 more sources

Nucleotide rigidity

Nature, 1976
It is show that in aqueous solution the backbone conformation of adenosine is as much flexible as that of 3'-AMP, 5'-AMP and 3', 5'-ADP indicating that nucleotides are not any more rigid than nucleosides. The flexible conformation of the monomeric components is conserved in the nucleotidyl units of destacked ApA, ApApA and poly(A), but it is not ...
F E, Evans, R H, Sarma
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Cyclic nucleotides

Phytochemistry, 2004
The natural occurrence of cyclic nucleotides in higher plants, formerly a topic of fierce debate, is now established, as is the presence of nucleotidyl cyclases and cyclic nucleotide phosphodiesterases capable of their synthesis and breakdown. Here we describe the significant properties of cyclic nucleotides, also outlining their second messenger ...
Russell P, Newton, Christopher J, Smith
openaire   +2 more sources

Targeted nucleotide editing using hybrid prokaryotic and vertebrate adaptive immune systems

Science, 2016
INTRODUCTION To combat invading pathogens, cells develop an adaptive immune response by changing their own genetic information. In vertebrates, the generation of genetic variation (somatic hypermutation) is an essential process for diversification and ...
K. Nishida   +11 more
semanticscholar   +1 more source

Nucleotide Metabolism

2011
Publisher Summary This chapter discusses the synthesis and degradation of nucleotides. A nucleotide consists of a purine or pyrimidine base, a pentose, and a phosphate. Nucleotides are synthesized by two types of metabolic pathways: de novo synthesis and salvage pathways.
Chung-Eun Ha, N.V. Bhagavan
openaire   +3 more sources

Isoquinolinesulfonamides, novel and potent inhibitors of cyclic nucleotide dependent protein kinase and protein kinase C.

Biochemistry, 1984
Naphthalenesulfonamides such as N-(6-amino-hexyl)-5-chloro-1-naphthalenesulfonamide (W-7) are potent calmodulin (CaM) antagonists and act upon several protein kinases at higher concentration.
H. Hidaka   +3 more
semanticscholar   +1 more source

The Biosynthesis of Nucleotides

2004
The synthesis of PRPP from ATP and ribose-5-phosphate is catalyzed by phosphoribosylpyrophosphate synthetase as follows:
openaire   +2 more sources

The metabolism of nucleotides

1986
A supply of ribonucleoside and deoxyribonucleoside 5′-triphosphates is required for the biosynthesis of nucleic acids (chapters 6 and 8). The synthesis of these compounds occurs in two main stages: (1) the formation of the purine and pyrimidine ring systems and their conversion into the parent ribonucleoside monophosphate, inosine 5′-monophosphate (IMP)
Roger L. P. Adams   +2 more
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The separation of nucleotides by isotachophoresis

Journal of Chromatography A, 1972
The mono-, di-, and triphosphates of adenosine, cytidine, guanosine, and uridine were sepd. by isotachophoresis in several different electrolyte systems. At lower pH, the differences in step-height were greater, and complete sepn. of a mixt.
FM Frans Everaerts, JL Jozef Beckers
openaire   +4 more sources

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