Results 31 to 40 of about 2,047,681 (342)

ATR inhibition facilitates targeting of leukemia dependence on convergent nucleotide biosynthetic pathways. [PDF]

open access: yes, 2017
Leukemia cells rely on two nucleotide biosynthetic pathways, de novo and salvage, to produce dNTPs for DNA replication. Here, using metabolomic, proteomic, and phosphoproteomic approaches, we show that inhibition of the replication stress sensing kinase ...
Abt, Evan R   +20 more
core   +2 more sources

The Interactions of Anti-HIV Pronucleotides with a Model Phospholipid Membrane

open access: yesMolecules
Pronucleotides, after entering the cell, undergo chemical or enzymatic conversion into nucleotides with a free phosphate residue, and the released nucleoside 5′-monophosphate is then phosphorylated to the biologically active form, namely nucleoside 5 ...
Monika Rojewska   +4 more
doaj   +1 more source

Effect of different levels of dietary nucleotide on immunity and total protein plasma parameters of Litopenaeus vannamei (Boone, 1931) female brood stock during maturation and eyestalk ablation [PDF]

open access: yesبوم‌شناسی آبزیان, 2016
In this study, we investigated the effects of different levels of dietary nucleotide (0, 0.2, 0.4 and 0.6%) on immunity parameters and total protein plasma of Litopenaeus vannamei female brood stock in four experimental treatments (three replication per ...
Ali Arshadi   +3 more
doaj  

Influence of Citrate and Phosphate on the Adsorption of Adenosine-5′-Monophosphate at the Hematite Water Interface

open access: yesFrontiers in Environmental Science, 2022
Nucleic acid derived organic phosphorus (Po) is an important source of plant available P when degraded to inorganic phosphate (P(V)i). It is known that when nucleic acids or components are adsorbed on mineral surfaces, the enzymatic degradation is ...
Sudipta Rakshit   +3 more
doaj   +1 more source

Food-chain competition influences gene's size

open access: yes, 2006
We have analysed an effect of the Bak-Sneppen predator-prey food-chain self-organization on nucleotide content of evolving species. In our model, genomes of the species under consideration have been represented by their nucleotide genomic fraction and we
Bak   +16 more
core   +1 more source

Genetic variability of Taenia saginata inferred from mitochondrial DNA sequences [PDF]

open access: yes, 2015
Taenia saginata is an important tapeworm, infecting humans in many parts of the world. The present study was undertaken to identify inter- and intraspecific variation of T.
Babaei, Z.   +5 more
core   +1 more source

Profile of Nucleotides and Nucleosides in Taiwanese Human Milk

open access: yesPediatrics and Neonatology, 2011
Human milk–borne nucleotides and their related metabolic products have been reported to have important physiological roles in breast-fed infants. The purpose of this study was to measure the concentrations of free nucleotides and nucleosides in human ...
Kuo-Yu Liao   +5 more
doaj   +1 more source

Facile Fabrication of Natural Polyelectrolyte-Nanoclay Composites: Halloysite Nanotubes, Nucleotides and DNA Study

open access: yesMolecules, 2020
Complexation of biopolymers with halloysite nanotubes (HNTs) can greatly affect their applicability as materials building blocks. Here we have performed a systematic investigation of fabrication of halloysite nanotubes complexes with nucleotides and ...
Svetlana Batasheva   +9 more
doaj   +1 more source

Synthesis and Calcium Mobilization Activity of cADPR Analogues Which Integrate Nucleobase, Northern and Southern Ribose Modifications

open access: yesMolecules, 2012
Novel cADPR mimics, which integrate nucleobase, northern and southern ribose modifications were synthesized. The key steps of the synthesis were a Cu(I)-catalyzed Hüisgen [3+2] cycloaddition and a microwave-assisted intramolecular pyrophosphorylation ...
Liangren Zhang   +6 more
doaj   +1 more source

MMP-2 geno-phenotype is prognostic for colorectal cancer survival, whereas MMP-9 is not. [PDF]

open access: yes, 2008
The prognostic significance of single-nucleotide polymorphisms (SNPs) and tumour protein levels of MMP-2 and MMP-9 was evaluated in 215 colorectal cancer patients.
Hawinkels, LJAC   +8 more
core   +2 more sources

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