Results 31 to 40 of about 2,769,148 (383)

EFFECTS OF DIETARY NUCLEOTIDES SUPPLEMENTATION ON THE PERFOR-MANCE OF BROILER CHICKS

open access: yesSlovenian Veterinary Research, 2023
This study examined the effects of nucleotide supplementation on broiler chick growth performance, immunological response, carcass traits, meat quality, serum biochemical parameters, total antioxidant capacity, intestinal morphology, mortality rate, and
Isayed I. Hassanein   +2 more
doaj   +1 more source

Inhibition of Subsets of G Protein-coupled Receptors by Empty Mutants of G Protein α Subunits in Go, G11, and G16 [PDF]

open access: yes, 2000
We previously reported that the xanthine nucleotide binding Goα mutant, GoαX, inhibited the activation of Gi-coupled receptors. We constructed similar mutations in G11α and G16α and characterized their nucleotide binding and receptor interaction.
Gu, Lingjie, Simon, Melvin I., Yu, Bo
core   +1 more source

ATR inhibition facilitates targeting of leukemia dependence on convergent nucleotide biosynthetic pathways. [PDF]

open access: yes, 2017
Leukemia cells rely on two nucleotide biosynthetic pathways, de novo and salvage, to produce dNTPs for DNA replication. Here, using metabolomic, proteomic, and phosphoproteomic approaches, we show that inhibition of the replication stress sensing kinase ...
Abt, Evan R   +20 more
core   +2 more sources

Molecular mechanism of Gαi activation by non-GPCR proteins with a Gα-Binding and Activating motif [PDF]

open access: yes, 2017
Heterotrimeric G proteins are quintessential signalling switches activated by nucleotide exchange on Gα. Although activation is predominantly carried out by G-protein-coupled receptors (GPCRs), non-receptor guanine-nucleotide exchange factors (GEFs) have
Baillie, George S.   +14 more
core   +1 more source

Comparative analysis of taste compounds in shiitake mushrooms processed by hot-air drying and freeze drying

open access: yesInternational Journal of Food Properties, 2019
Shiitake mushrooms were processed by hot-air drying (HD) and freeze-drying (FD) to investigate the taste compounds. The total free amino acids in HD samples treated at 60°C was the highest as compared to the other three dried samples.
Xiao Yang   +5 more
doaj   +1 more source

RNA interference is mediated by 21- and 22-nucleotide RNAs.

open access: yesGenes & Development, 2001
Double-stranded RNA (dsRNA) induces sequence-specific posttranscriptional gene silencing in many organisms by a process known as RNA interference (RNAi). Using a Drosophila in vitro system, we demonstrate that 21- and 22-nt RNA fragments are the sequence-
Sayda M. Elbashir   +2 more
semanticscholar   +1 more source

The Interactions of Anti-HIV Pronucleotides with a Model Phospholipid Membrane

open access: yesMolecules
Pronucleotides, after entering the cell, undergo chemical or enzymatic conversion into nucleotides with a free phosphate residue, and the released nucleoside 5′-monophosphate is then phosphorylated to the biologically active form, namely nucleoside 5 ...
Monika Rojewska   +4 more
doaj   +1 more source

Profile of Nucleotides and Nucleosides in Taiwanese Human Milk

open access: yesPediatrics and Neonatology, 2011
Human milk–borne nucleotides and their related metabolic products have been reported to have important physiological roles in breast-fed infants. The purpose of this study was to measure the concentrations of free nucleotides and nucleosides in human ...
Kuo-Yu Liao   +5 more
doaj   +1 more source

Exploring the nucleotide molecular mechanism of compound kushen injection for lung adenocarcinoma based on network pharmacology and molecular docking

open access: yesFrontiers in Oncology, 2022
Compound kushen injection is an effective traditional Chinese medicine for the treatment of lung cancer. However, its influence on the survival and prognosis of patients with lung adenocarcinoma patients was less studied; especially its pharmacological ...
Zhangpeng Ye   +9 more
doaj   +1 more source

Food-chain competition influences gene's size

open access: yes, 2006
We have analysed an effect of the Bak-Sneppen predator-prey food-chain self-organization on nucleotide content of evolving species. In our model, genomes of the species under consideration have been represented by their nucleotide genomic fraction and we
Bak   +16 more
core   +1 more source

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