Results 71 to 80 of about 2,769,148 (383)

5\u27-Terminal nucleotide variations in human cytoplasmic tRNAHisGUG and its 5\u27-halves. [PDF]

open access: yes, 2017
Transfer RNAs (tRNAs) are fundamental adapter components of translational machinery. tRNAs can further serve as a source of tRNA-derived noncoding RNAs that play important roles in various biological processes beyond translation.
Kirino, Yohei, Shigematsu, Megumi
core   +1 more source

p22phox C242T Single-Nucleotide Polymorphism Inhibits Inflammatory Oxidative Damage to Endothelial Cells and Vessels. [PDF]

open access: yes, 2016
BACKGROUND: The NADPH oxidase, by generating reactive oxygen species, is involved in the pathophysiology of many cardiovascular diseases and represents a therapeutic target for the development of novel drugs.
Brooks, G   +6 more
core   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

open access: yesFEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva   +5 more
wiley   +1 more source

Sự đa dạng di truyền của bảy dòng cam Sành không hạt được phát hiện năm 2013 tại Hậu Giang dựa trên trình tự matK

open access: yesTạp chí Khoa học Đại học Cần Thơ, 2016
Để có thông tin đặc điểm về di truyền của bảy dòng cam Sành không hạt được phát hiện năm 2013 tại Hậu Giang, đề tài được thực hiện với mục tiêu có thể phân biệt các dòng cam Sành không hạt với nhau và với các dòng cam Sành phổ biến khác, đặc biệt là dòng
Lê Minh Triết   +2 more
doaj   +1 more source

Nucleotide Excision Repair

open access: yesDefinitions, 2020
European Bioinformatics Institute, New York University Langone Medical Center, Ontario Institute for Cancer Research, Oregon Health and Science University.
W. Mcgregor
semanticscholar   +1 more source

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

open access: yesFEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva   +10 more
wiley   +1 more source

Single-nucleotide resolution mapping of m6A and m6Am throughout the transcriptome

open access: yesNature Methods, 2015
N6-methyladenosine (m6A) is the most abundant modified base in eukaryotic mRNA and has been linked to diverse effects on mRNA fate. Current mapping approaches localize m6A residues to transcript regions 100–200 nt long but cannot identify precise m6A ...
Bastian Linder   +5 more
semanticscholar   +1 more source

Impact of Tandem Repeats on the Scaling of Nucleotide Sequences

open access: yes, 2005
Techniques such as detrended fluctuation analysis (DFA) and its extensions have been widely used to determine the nature of scaling in nucleotide sequences.
Bashir R.   +4 more
core   +1 more source

Glucose inhibits cardiac muscle maturation through nucleotide biosynthesis. [PDF]

open access: yes, 2017
The heart switches its energy substrate from glucose to fatty acids at birth, and maternal hyperglycemia is associated with congenital heart disease. However, little is known about how blood glucose impacts heart formation.
Braas, Daniel   +21 more
core   +2 more sources

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

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