Results 71 to 80 of about 670,950 (297)
Ion channel function of polycystin‐2/polycystin‐1 heteromer revealed by structure‐guided mutagenesis
FEBS Letters, EarlyView.Mutations in polycystin‐1 (PC1) or polycystin‐2 (PC2) cause autosomal‐dominant polycystic kidney disease (ADPKD). We generated a novel gain‐of‐function PC2/PC1 heteromeric ion channel by mutating pore‐blocking residues. Moreover, we demonstrated that PC2 will preferentially assemble with PC1 to form heteromeric complexes when PC1 is co‐expressed ...
Tobias Staudner +7 more
wiley +1 more source
Molecular biology and evolution, 1992 A simple mathematical method is developed to estimate the number of nucleotide substitutions per site between two DNA sequences, by extending Kimura's (1980) two-parameter method to the case where a G+C-content bias exists.
K. Tamura
semanticscholar +1 more source
Bacteria compositions and metabolites of kimchi as affected by salted shrimp (saeujeot)
International Journal of Food Properties, 2022 This study aimed to investigate the effects of salted shrimp on kimchi fermentation. Four types of kimchi (KWD, KWR, KWC, and KWY), based on the variety of salted shrimp (Detteugijeot, Red shrimp jeot, Chujeot, and Yukjeot, respectively), were prepared ...
Ju-Young Lim +11 more
doaj +1 more source
Decoding the dual role of autophagy in cancer through transcriptional and epigenetic regulation
FEBS Letters, EarlyView.Transcriptional and epigenetic regulation controls autophagy, which exerts context‐dependent effects on cancer: Autophagy suppresses tumorigenesis by maintaining cellular homeostasis or promotes tumor progression by supporting survival under stress. In this “In a Nutshell” article, we explore the intricate mechanisms of the dual function of autophagy ...
Young Suk Yu, Ik Soo Kim, Sung Hee Baek
wiley +1 more source
Biology, 2020 Machine learning algorithms can learn mechanisms of antimicrobial resistance from the data of DNA sequence without any a priori information. Interpreting a trained machine learning algorithm can be exploited for validating the model and obtaining new ...
Taha ValizadehAslani +3 more
doaj +1 more source
The international nucleotide sequence database collaboration
Nucleic Acids Res., 2020 The International Nucleotide Sequence Database Collaboration (INSDC; http://www.insdc.org/) has been the core infrastructure for collecting and providing nucleotide sequence data and metadata for >30 years.
Masanori Arita +2 more
semanticscholar +1 more source
Evaluation of non-volatile taste components in commercial soy sauces
International Journal of Food Properties, 2018 The dominating non-volatile taste compounds in commercial brewed soy sauces were determined by HPLC and evaluated on the contributions to overall taste.
Yan Kong +6 more
doaj +1 more source
Mechanochemistry of nucleosides, nucleotides and related materials
Beilstein Journal of Organic Chemistry, 2018 The application of mechanical force to induce the formation and cleavage of covalent bonds is a rapidly developing field within organic chemistry which has particular value in reducing or eliminating solvent usage, enhancing reaction rates and also in ...
Olga Eguaogie +4 more
doaj +1 more source
Bacterial cGAS-like enzymes synthesize diverse nucleotide signals
Nature, 2019 Cyclic dinucleotides (CDNs) have central roles in bacterial homeostasis and virulence by acting as nucleotide second messengers. Bacterial CDNs also elicit immune responses during infection when they are detected by pattern-recognition receptors in ...
A. T. Whiteley +10 more
semanticscholar +1 more source
SAMHD1: Recurring roles in cell cycle, viral restriction, cancer, and innate immunity
Autoimmunity, 2018 Sterile alpha motif and histidine-aspartic acid domain-containing protein 1 (SAMHD1) is a deoxynucleotide triphosphate (dNTP) hydrolase that plays an important role in the homeostatic balance of cellular dNTPs.
Christopher H. Mauney, Thomas Hollis
doaj +1 more source