Results 91 to 100 of about 94,282 (203)
A role for chromatin remodellers in replication of damaged DNA [PDF]
, 2011 In eukaryotic cells, replication past damaged sites in DNA is regulated by the ubiquitination of proliferating cell nuclear antigen (PCNA). Little is known about how this process is affected by chromatin structure.
Chambers, Anna L +3 more
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Molecules, 2016 Nucleoside/nucleotide analogs that lack the 3′-hydroxy group are widely utilized for HIV therapy. These chain-terminating nucleoside analogs (CTNAs) block DNA synthesis after their incorporation into growing DNA, leading to the antiviral effects. However,
Junpei Yamamoto +4 more
doaj +1 more source
Nucleotide Excision Repair in Mammalian Cells [PDF]
Journal of Biological Chemistry, 1997 is found throughout thenatural world in organisms ranging from mycoplasma to mam-mals. In humans, NER is a major defense against the carcino-genic effects of ultraviolet light from the sun. This repair path-way acts with varying efficiencies on a wide variety of DNAalterations and is especially important for bulky, helix-distort-ing lesions.
openaire +2 more sources
Experimental Acute Exposure to Thirdhand Smoke and Changes in the Human Nasal Epithelial Transcriptome: A Randomized Clinical Trial. [PDF]
, 2019 Importance:No previous studies have shown that acute inhalation of thirdhand smoke (THS) activates stress and survival pathways in the human nasal epithelium.
Girke, Thomas +5 more
core +1 more source
Conserved 3D genome reorganization during DNA repair
Life Science AllianceThis review synthesizes findings from genomic, molecular, and disease studies that chromatin organization dynamically shapes diverse DNA repair pathways, with translational potential for therapeutic intervention.
Veysel Oğulcan Kaya +3 more
doaj +1 more source
Chinese Journal of Lung Cancer, 2010 Background and objective Proteins of the nucleotide excision repair pathway can repair DNA damage. The excision repair cross-complementing (ERCC) gene family reduce damagement of DNA by nucleotide excision and repair.
Jinchen SHAO, Jie ZHANG, Zhengping DING
doaj
DNA Damage Induced by Alkylating Agents and Repair Pathways
Journal of Nucleic Acids, 2010 The cytotoxic effects of alkylating agents are strongly attenuated by cellular DNA repair processes, necessitating a clear understanding of the repair mechanisms. Simple methylating agents form adducts at N- and O-atoms.
Natsuko Kondo +3 more
doaj +1 more source
Comparison of phenanthriplatin, a novel monofunctional platinum based anticancer drug candidate, with cisplatin, a classic bifunctional anticancer drug [PDF]
, 2012 Thesis (S.M. in Inorganic chemistry)--Massachusetts Institute of Technology, Dept. of Chemistry, 2012.Cataloged from PDF version of thesis. Vita.Includes bibliographical references (p.
Li, Meiyi, S.M. Massachusetts Institute of Technology
core
A theory for the tissue specificity of BRCA1/2 related and other hereditary cancers [PDF]
, 2010 Women who inherit a defective BRCA1 or BRCA2 gene have risks for breast and ovarian cancer that are so high and seem so selective that many mutation carriers choose to have prophylactic surgery. There has been much conjecture to explain such apparently
Bernard Friedenson
core +1 more source
Nucleotide excision repair syndromes
Philosophical Transactions of the Royal Society B: Biological Sciences, 1995 The phenotypic consequences of a nucleotide excision repair (NER) defect in man are apparent from three distinct inborn diseases characterized by hypersensitivity of the skin to ultraviolet light and a remarkable clinical and genetic heterogeneity. These are the prototype repair syndrome, xeroderma pigmentosum (XP) (seven genetic complementation groups,
Bootsma, D. +6 more
openaire +1 more source