Results 201 to 210 of about 98,783 (332)

NAD⁺ Reduction in Glutamatergic Neurons Induces Lipid Catabolism and Neuroinflammation in the Brain via SARM1

Advanced Science, EarlyView.
NAD⁺ homeostasis maintains neuronal integrity through opposing actions of NMNAT2 and SARM1. Loss of NMNAT2 in glutamatergic neurons reprograms cortical metabolism from glucose to lipid catabolism, depletes lipid stores, and triggers inflammation and neurodegeneration.
Zhen‐Xian Niou, Sen Yang, Andrea Enriquez, Nino A. Espinas, Anoosha Sri, Caliel D. Hines, Jason M. Tennessen, Chia‐Shan Wu, Jui‐Yen Huang, Hui‐Chen Lu   +9 more
wiley   +1 more source

Arid1a Deficiency Drives Aristolochic Acid-Induced Liver Tumorigenesis through Ctnnb1 Mutation and Defective Nucleotide Excision Repair. [PDF]

Adv Sci (Weinh)
Wang L, Bai SH, Song SJ, Zhang XL, Shang XY, Lu ZN, Cui XF, Zhu XL, Han ZG.   +8 more
europepmc   +1 more source

Nucleotide excision repair in Human cell lines lacking both XPC and CSB proteins. [PDF]

Nucleic Acids Res, 2023
Lindsey-Boltz LA, Yang Y, Kose C, Deger N, Eynullazada K, Kawara H, Sancar A.   +6 more
europepmc   +1 more source

Data from Green Tea Polyphenols Prevent UV-Induced Immunosuppression by Rapid Repair of DNA Damage and Enhancement of Nucleotide Excision Repair Genes

, 2023
Santosh K. Katiyar, Mudit Vaid, Harry van Steeg, Syed Musthapa Meeran   +3 more
openalex   +1 more source

Comprehensive Profiling of N6‐methyladnosine (m6A) Readouts Reveals Novel m6A Readers That Regulate Human Embryonic Stem Cell Differentiation

Advanced Science, EarlyView.
This research deciphers the m6A transcriptome by profiling its sites and functional readout effects: from mRNA stability, translation to alternative splicing, across five different cell types. Machine learning model identifies novel m6A‐binding proteins DDX6 and FXR2 and novel m6A reader proteins FUBP3 and L1TD1.
Zhou Huang, Rucong Liu, Zibaguli Wubulikasimu, Wanqing Zhao, Jiaqi Huang, Jiaxuan Wang, Tianyuan Zhang, Rui Fan, Wei Kong, Qinghua Cui, Yang Li, Yuan Zhou   +11 more
wiley   +1 more source

Role of the nucleotide excision repair endonuclease XPF in the kinetoplastid parasite Trypanosoma brucei. [PDF]

Sci Rep
Gómez-Liñán C, Sáez-Maldonado M, Montosa-Hidalgo L, Ruiz-Pérez LM, González-Pacanowska D, Vidal AE.   +5 more
europepmc   +1 more source

ASH1L-MRG15 methyltransferase deposits H3K4me3 and FACT for damage verification in nucleotide excision repair. [PDF]

Nat Commun, 2023
Maritz C, Khaleghi R, Yancoskie MN, Diethelm S, Brülisauer S, Ferreira NS, Jiang Y, Sturla SJ, Naegeli H.   +8 more
europepmc   +1 more source

Checkpoint Kinase ATR Promotes Nucleotide Excision Repair of UV-induced DNA Damage via Physical Interaction with Xeroderma Pigmentosum Group A [PDF]

, 2009
Steven M. Shell, Zhengke Li, Nikolozi Shkriabai, Mamuka Kvaratskhelia, Chris A. Brosey, Moises Serrano, Walter Chazin, Phillip R. Musich, Yue Zou   +8 more
openalex   +1 more source

Mammalian nucleotide excision repair and syndromes [PDF]

Biochemical Society Transactions, 1997
Vermeulen, Wim, de Boer, J (Jan), Citterio, E (Elisabetta), van Gool, AJ (Alain), van der Horst, Bert, Jaspers, Koos, de Laat, WL (Wouter), Sijbers, AM (Anneke), van der Spek, Peter, Sugasawa, K, Weeda, G (Geert), Winkler, GS (Sebastiaan), Bootsma, Dirk, Egly, JM, Hoeijmakers, Jan   +14 more
openaire   +3 more sources

Lactylation‐Driven YTHDC1 Alleviates MASLD by Suppressing PTPN22‐Mediated Dephosphorylation of NLRP3

Advanced Science, EarlyView.
In MASLD, YTHDC1 undergoes increased lactylation and ubiquitination, reducing its expression. AARS1 mediates lactylation at lysine 565, while disrupted binding to LDHA further promotes lactylation, suppressing YTHDC1. This downregulation enhances PTPN22 mRNA stability, leading to NLRP3 dephosphorylation and activation, which exacerbates inflammation ...
Feng Zhang, Linghua Zeng, Kunkun Zou, Keying Lin, Fangting Yao, Jinglun Song, Shumeng Zhang, Hanshu Feng, Zhichao Yang, Chunlei Wang, Hongtao Diao, Xue Kong, Tengfei Pan, Joonki Kim, Tianqi Duo, Linqiang Li, Yu Bian   +16 more
wiley   +1 more source