Results 211 to 220 of about 127,063 (412)

B Lymphocytes of Xeroderma Pigmentosum or Cockayne Syndrome Patients with Inherited Defects in Nucleotide Excision Repair Are Fully Capable of Somatic Hypermutation of Immunoglobulin Genes [PDF]

, 1997
N. Kim, Karen Kage, Fumihiko Matsuda, Marie‐Paule Lefranc, Ursula Storb   +4 more
openalex   +1 more source

Mammalian nucleotide excision repair and syndromes [PDF]

Biochemical Society Transactions, 1997
Anneke M. Sijbers, Geert Weeda, J. B. De Boer, Jan H.J. Hoeijmakers, W. L. de Laat, G. S. Winkler, Wim Vermeulen, Dirk Bootsma, G.T.J. van der Horst, P.J. van der Spek, Elisabetta Citterio, A. J. van Gool, Kaoru Sugasawa, Nicolaas G. J. Jaspers, Jean-Marc Egly   +14 more
openaire   +4 more sources

Integrative Multi‐Omics and Routine Blood Analysis Using Deep Learning: Cost‐Effective Early Prediction of Chronic Disease Risks

Advanced Science, EarlyView.
Omicsformer, a deep learning model, integrates multi‐omics and routine blood data to accurately predict risks for nine chronic diseases, including cancer and cardiovascular conditions. Validated using large scale clinical data, it reveals early risk trajectories, advancing personalized medicine and offering a cost‐effective, community‐based solution ...
Zhibin Dong, Pei Li, Yi Jiang, Zhihan Wang, Shihui Fu, Hebin Che, Meng Liu, Xiaojing Zhao, Chunlei Liu, Chenghui Zhao, Qin Zhong, Chongyou Rao, Siwei Wang, Suyuan Liu, Dayu Hu, Dongjin Wang, Juntao Gao, Kai Guo, Xinwang Liu, En Zhu, Kunlun He   +20 more
wiley   +1 more source

Rapid changes of nucleotide excision repair gene expression following UV-irradiation and cisplatin treatment of Dictyostelium discoideum [PDF]

, 1998
Sung‐Liang Yu, Sang‐Kyu Lee, Hannah Alexander, Stephen Alexander   +3 more
openalex   +1 more source

Dissecting the Spatial and Single‐Cell Transcriptomic Architecture of Cancer Stem Cell Niche Driving Tumor Progression in Gastric Cancer

Advanced Science, EarlyView.
A single‐cell and spatial transcriptional atlas reveals the architecture of human gastric cancer stem cell (CSC) niche and the developmental trajectory of CSCs. These CSCs interact with immunosuppressive immune cells thereby constructing immune‐suppressive niche, and inflammatory cancer‐associated fibroblast (iCAFs) to enhance stemness through ...
Guangyu Zhang, Xin Zhang, Wenting Pan, Xizhao Chen, Lingfei Wan, Chunjie Liu, Yuting Yong, Yue Zhao, Shuli Sang, Lihua Zhang, Sheng Yao, Yushu Guo, Mingmei Wang, Xinhui Wang, Guangdun Peng, Xinlong Yan, Yanchun Wang, Min Zhang   +17 more
wiley   +1 more source

XRCC1, but not APE1 and hOGG1 gene polymorphisms is a risk factor for pterygium. [PDF]

, 2010
PurposeEpidemiological evidence suggests that UV irradiation plays an important role in pterygium pathogenesis. UV irradiation can produce a wide range of DNA damage.
Chen, Pei-Liang, Cheng, Ya-Wen, Koeh, Hank, Lee, Huei, Liu, Yu-Ling, Tsai, Yi-Yu, Yeh, Kun-Tu   +6 more
core   +1 more source

NKX2‐5/LHX1 and UHRF1 Establishing a Positive Feedback Regulatory Circuitry Drives Esophageal Squamous Cell Carcinoma through Epigenetic Dysregulation

Advanced Science, EarlyView.
The study identifies a positive feed‐forward loop that intertwines DNA methylation regulator UHRF1 with Homeobox genes‐NKX2‐5/LHX1 via UMRs as a critical driver of ESCC. Pharmacological inhibition of UHRF1 and DNMT activity inhibits ESCC growth, which may represent a promising therapeutic approach to treat ESCC patients dependent on NKX2‐5/LHX1/UHRF1 ...
Xukun Li, Dandan Fan, Yong Li, Jian Yuan, Wanyuan Sun, Qinghao Zhu, Ling Qi, Xueling Wu, Jiahui Cai, Tongyang Gong, Ning Zhao, Jianzhong Su, Zhihua Liu, Hongyan Chen   +13 more
wiley   +1 more source

Nucleotide excision repair in Human cell lines lacking both XPC and CSB proteins. [PDF]

Nucleic Acids Res, 2023
Lindsey-Boltz LA, Yang Y, Kose C, Deger N, Eynullazada K, Kawara H, Sancar A.   +6 more
europepmc   +1 more source

HHR23B, a Human Rad23 Homolog, Stimulates XPC Protein in Nucleotide Excision Repair In Vitro [PDF]

, 1996
Kaoru Sugasawa, Chikahide Masutani, Akio Uchida, Takafumi Maekawa, Peter J. van der Spek, D. Bootsma, Jan H.J. Hoeijmakers, Fumio Hanaoka   +7 more
openalex   +1 more source

A Model of Epigenetic Inheritance Accounts for Unexpected Adaptation to Unforeseen Challenges

Advanced Science, EarlyView.
A general model of inheriting changes that are acquired during the lifetime of individuals demonstrates tremendous benefits to the population, including escape from extinction in changing environments. Contrasting the model with experimental data shows that inheritance of acquired changes enables rapid adaptation to unforeseen challenges, and accounts ...
Dino Osmanović, Yitzhak Rabin, Yoav Soen   +2 more
wiley   +1 more source