Results 241 to 250 of about 82,343 (351)

CircTP53/USP10/p53 signaling Axis as a Novel Regulator of Progression and Prognosis of Head and Neck Squamous Cell Carcinoma

Advanced Science, EarlyView.
The study identifies a novel circular RNA derived from the TP53 gene (circTP53), which is upregulated in HNSCC and correlates with poor patient prognosis. It demonstrates that circTP53 promotes HNSCC progression by interacting with USP10, stabilizing both proteins, enhancing deubiquitination of p53, and thereby influencing tumor growth, with its ...
Yin Wang, Fen Chang, Zinan Li, Chengcheng Duan, Xiangkai Sun, Siyu Wang, Dongmin Wei, Wenming Li, Ye Qian, Shengda Cao, Juan Zhao, Dapeng Lei   +11 more
wiley   +1 more source

Molecular architecture and functional dynamics of the pre-incision complex in nucleotide excision repair. [PDF]

Nat Commun
Yu J, Yan C, Paul T, Brewer L, Tsutakawa SE, Tsai CL, Hamdan SM, Tainer JA, Ivanov I.   +8 more
europepmc   +1 more source

Editor's note on 'interaction of p21CDKN1A with PCNA regulates the histone acetyltransferase activity of p300 in nucleotide excision repair'. [PDF]

Nucleic Acids Res, 2023
europepmc   +1 more source

PTEN-negative endometrial cancer cells protect their genome through enhanced DDB2 expression associated with augmented nucleotide excision repair. [PDF]

BMC Cancer, 2023
Hameed J S F, Devarajan A, M S DP, Bhattacharyya A, Shirude MB, Dutta D, Karmakar P, Mukherjee A.   +7 more
europepmc   +1 more source

PKD1 Unusual DNA Conformations Are Recognized by Nucleotide Excision Repair [PDF]

, 2001
Albino Bacolla, Adam Jaworski, Timothy D. Connors, Robert D. Wells   +3 more
openalex   +1 more source

Biosecurity Primitive: Polymerase X‐based Genetic Physical Unclonable Functions

Advanced Science, EarlyView.
What if every cell line can carry an unforgeable genomic fingerprint—one that proves its origin, ensures its authenticity, and thwarts unauthorized duplication? Here, CRISPR‐induced DNA lesions paired with TdT‐mediated repair produce robust, unique, and unclonable genetic signatures—advancing the concept of molecular Physical Unclonable Functions (PUF)
Zikun Zhou, Taek Kang, Jie Chen, Yesh Doctor, Jocelyn G Camposagrado, Yiorgos Makris, Alexander Pertsemlidis, Leonidas Bleris   +7 more
wiley   +1 more source

Beyond Nucleotide Excision Repair: The Importance of XPF in Base Excision Repair and Its Impact on Cancer, Inflammation, and Aging. [PDF]

Int J Mol Sci
Gohil D, Roy R.
europepmc   +1 more source

Accessibility of DNA polymerases to repair synthesis during nucleotide excision repair in yeast cell-free extracts [PDF]

, 2001
Xi Wu
openalex   +1 more source

POLE Deficiency Exacerbates Diesel Engine Exhaust‐Induced Genomic Instability and Malignant Transformation of Bronchial Epithelial Cells

Advanced Science, EarlyView.
This study establishes a diesel engine exhaust (DEE)‐induced malignant transformation model in bronchial epithelial cells. Whole genome sequencing（WGS） and RNA‐seq reveal DEE‐induced mutational signatures and gene expression profiles. Mechanistically, DEEaffect polymerase epsilon (POLE) and mismatch repair, driving genomic instability and promoting ...
Pimei Zhang, Zhaoxu Wu, Qiang Ju, Nuo Xu, Xian Chen, Hongguang Chen, Shuaishuai Yang, Jing Ji, Yanjie Zhao   +8 more
wiley   +1 more source

Nucleotide excision repair of aflatoxin-induced DNA damage within the 3D human genome organization. [PDF]

Nucleic Acids Res
Wu Y, Adeel MM, Xia D, Sancar A, Li W.
europepmc   +1 more source