Results 81 to 90 of about 94,282 (203)

Non-homologous end-joining pathway associated with occurrence of myocardial infarction: gene set analysis of genome-wide association study data [PDF]

, 2013
<p>Purpose: DNA repair deficiencies have been postulated to play a role in the development and progression of cardiovascular disease (CVD). The hypothesis is that DNA damage accumulating with age may induce cell death, which promotes formation of ...
A Choudhury, A Torkamani, AL Dixon, AP Bazo, B Arcidiacono, Bastiaan T. Heijmans, BJ Lamarche, Brendan M. Buckley, C Matthews, CD Ragnauth, Consortium Wellcome Trust Case Control, D Thorne, David J. Stott, E Durand, E Poch, F Gizard, G Bauriedel, G Macintyre, G Perez-Rivero, G Voghel, GJ Williams, GS Stewart, H Gui, H Schunkert, Henk-Jan Guchelaar, HY Shyu, Ian Ford, IS Ockene, J Shepherd, J Shepherd, J. Wouter Jukema, Jeanine J. Houwing-Duistermaat, Jeffrey J. W. Verschuren, Joris Deelen, JR Mercer, K Allen-Brady, K Wang, LS Waters, M Corral-Debrinski, M Durik, M Kanehisa, M Mahmoudi, M Satoh, MA Loizidou, MF Moffatt, MG Andreassi, MK Shimada, ML Rossi, ML Sampietro, Naveed Sattar, NJ Samani, OK Mirzoeva, P. Eline Slagboom, S Furukawa, S Knudsen, S Mahabir, S Ozturk, S Purcell, S Purcell, S Trompet, SC Liu, Sergey Korolev, Stella Trompet, T Minamino, T Zeller, V Borde, V Borde, WR Agema, X Xie, Y Li, YB Park   +70 more
core   +3 more sources

Mfd Protects Against Oxidative Stress in Bacillus Subtilis Independently of its Canonical Function in DNA Repair [PDF]

, 2019
Background: Previous reports showed that mutagenesis in nutrient-limiting conditions is dependent on Mfd in Bacillus subtilis. Mfd initiates one type of transcription-coupled repair (TCR); this type of repair is known to target bulky lesions, like those ...
Contreras, Natalie, Ermi, Tatiana, Martin, Holly Anne, Pedraza-Reyes, Mario, Porter, Katelyne E., Robleto, Eduardo, Vallin, Carmen   +6 more
core   +5 more sources

Nucleotide excision repair in Escherichia coli [PDF]

Microbiological Reviews, 1990
One of the best-studied DNA repair pathways is nucleotide excision repair, a process consisting of DNA damage recognition, incision, excision, repair resynthesis, and DNA ligation. Escherichia coli has served as a model organism for the study of this process. Recently, many of the proteins that mediate E.
openaire   +2 more sources

Chromatin structure and DNA damage repair

Epigenetics & Chromatin, 2008
The integrity of the genome is continuously challenged by both endogenous and exogenous DNA damaging agents. These damaging agents can induce a wide variety of lesions in the DNA, such as double strand breaks, single strand breaks, oxidative lesions and ...
Dinant Christoffel, Houtsmuller Adriaan B, Vermeulen Wim   +2 more
doaj   +1 more source

Structure and Function of a Mycobacterial NHEJ DNA Repair Polymerase [PDF]

, 2006
Non homologous end-joining (NHEJ)-mediated repair of DNA double-strand breaks in prokaryotes requires Ku and a specific multidomain DNA ligase (LigD).
Aidan J. Doherty, Angel J. Picher, Arezi, Augustin, Bowater, Chen, Chen, Critchlow, Daley, Darren Thompson, DeFazio, Della, Dominguez, Emsley, Garcia-Diaz, Gavin C. Fox, Gong, Gong, Ito, Iyer, Jones, Krejci, La Fortelle, Lao-Sirieix, Lao-Sirieix, Lipps, Luis Blanco, Ma, Ma, Mahajan, Matsumoto, McCoy, Murshudov, Nick McElhinney, Nick McElhinny, Nick McElhinny, Nigel C. Brissett, Paula Andrade, Paull, Picher, Pitcher, Pitcher, Potterton, Potterton, Powell, Prasad, Ramsden, Raquel Juarez, Robert S. Pitcher, Ruiz, Rydberg, Singhal, Steitz, Tseng, Weller, Wilson, Winn, Wu, Zhang, Zhu   +59 more
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DNA Repair Gene Polymorphisms May Be Associated with Prognosis of Upper Urinary Tract Transitional Cell Carcinoma

Neoplasia: An International Journal for Oncology Research, 2008
Upper urinary tract transitional cell carcinoma (UUT-TCC) is quite an uncommon disease, and its prognosis differs among individuals irrespective of tumor stage. DNA repair gene polymorphisms are reported to result in the modulation of the repair capacity
Miwa Sasaki, Shigeru Sakano, Naoko Okayama, Jumpei Akao, Tomohiko Hara, Yoshihisa Kawai, Chietaka Ohmi, Yuji Hinoda, Katsusuke Naito   +8 more
doaj   +1 more source

Nothing in excess - lessons learned from the expression of high-mobility group proteins type A in non-cancer and cancer cells [PDF]

, 2011
High-mobility group A (HMGA) proteins are major transcription regulators which are abundantly and ubiquitously expressed in undifferentiated cells but present at a low level in somatic cells of adult organisms.
Petkova, Rumena, Tummala, Hemanth, Zhelev, Nikolai   +2 more
core   +3 more sources

Interplay of replication timing, DNA repair, and translesion synthesis in UV mutagenesis in yeast

Nucleus
Replication timing during S-phase impacts mutation rates in yeast and human cancers; however, the exact mechanism involved remains unclear. Here, we analyze the impact of replication timing on UV mutagenesis in Saccharomyces cerevisiae.
Allysa Sewell, John J. Wyrick
doaj   +1 more source

Phosphorylated HBO1 at UV irradiated sites is essential for nucleotide excision repair

Nature Communications, 2017
Repair of cyclobutane pyrimidine dimers requires access to DNA by the nucleotide excision repair machinery. Here the authors show that HBO1 facilitates accumulation of SNF2H and ACF1 to make chromatin more accessible after ultraviolet damage.
Hiroyuki Niida, Ryoichi Matsunuma, Ryo Horiguchi, Chiharu Uchida, Yuka Nakazawa, Akira Motegi, Koji Nishimoto, Satoshi Sakai, Tatsuya Ohhata, Kyoko Kitagawa, Shinichi Moriwaki, Hideo Nishitani, Ayako Ui, Tomoo Ogi, Masatoshi Kitagawa   +14 more
doaj   +1 more source

ERCC1 and XRCC1 as biomarkers for lung and head and neck cancer

Pharmacogenomics and Personalized Medicine, 2011
Alec Vaezi1,2, Chelsea H Feldman2, Laura J Niedernhofer2,31Department of Otolaryngology and Head and Neck Surgery, University of Pittsburgh School of Medicine, 2University of Pittsburgh Cancer Institute, 3Department of Microbiology and Molecular Genetics,
Vaezi A, Feldman CH, Niedernhofer LJ
doaj