Results 121 to 130 of about 458,823 (303)

Association mapping and marker-assisted selection of the lettuce dieback resistance gene Tvr1

BMC Plant Biology, 2009
Background Lettuce (Lactuca saliva L.) is susceptible to dieback, a soilborne disease caused by two viruses from the family Tombusviridae. Susceptibility to dieback is widespread in romaine and leaf-type lettuce, while modern iceberg cultivars are ...
Scheffler Brian, McHale Leah, Truco María, Ochoa Oswaldo, Michelmore Richard, Simko Ivan, Pechenick Dov   +6 more
doaj  

Gene-Based Single Nucleotide Polymorphism Markers for Genetic and Association Mapping in Common Bean

BMC Genetics, 2012
Background In common bean, expressed sequence tags (ESTs) are an underestimated source of gene-based markers such as insertion-deletions (Indels) or single-nucleotide polymorphisms (SNPs).
Galeano Carlos H, Cortés Andrés J, Fernández Andrea C, Soler Álvaro, Franco-Herrera Natalia, Makunde Godwill, Vanderleyden Jos, Blair Matthew W   +7 more
doaj   +1 more source

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

FEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon, Angéla Békesi, Latifa Kazzazy, Jázmin Mihály, Máté Varga, Beáta G. Vértessy, Kinga Nyíri   +6 more
wiley   +1 more source

Single nucleotide-level mapping of DNA double-strand breaks in human HEK293T cells

Genomics Data, 2017
Constitutional biological processes involve the generation of DNA double-strand breaks (DSBs). The production of such breaks and their subsequent resolution are also highly relevant to neurodegenerative diseases and cancer, in which extensive DNA ...
Bernard J. Pope, Khalid Mahmood, Chol-hee Jung, Peter Georgeson, Daniel J. Park   +4 more
doaj   +1 more source

HIV‐1 establishes immediate latency in T cells expressing the viral Nef protein

FEBS Open Bio, EarlyView.
Nef is a viral protein often omitted from HIV‐1 reporter viruses. Consequently, its role in viral latency is unclear. We developed three novel dual reporter HIV‐1 derivatives that express Nef and allow for detection of latent and productive infection. Using these reporters, we show that Nef does not affect the establishment of immediate viral latency ...
Cindy Lam, Ivan Sadowski
wiley   +1 more source

Single-Nucleotide Resolution Mapping of N6‑Methyladenine in Genomic DNA

ACS Central Science, 2023
Cheng-Jie Ma, Gaojie Li, Wen-Xuan Shao, Yi-Hao Min, Ping Wang, Jiang-Hui Ding, Neng-Bin Xie, Min Wang, Feng Tang, Yu-Qi Feng, Weimin Ci, Yinsheng Wang, Bi-Feng Yuan   +12 more
doaj   +1 more source

Genomic Exploration of Essential Hypertension in African‐Brazilian Quilombo Populations: A Comprehensive Approach With Pedigree Analysis and Family‐Based Association Studies

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background Essential hypertension (EH) is a global health issue. Despite extensive research, much of EH heritability remains unexplained. We investigated the genetic basis of EH in African‐derived individuals from partially isolated quilombo populations ...
Vinicius Magalhães Borges, Andrea R. V. R. Horimoto, Ellen Marie Wijsman, Lilian Kimura, Kelly Nunes, Alejandro Q. Nato, Regina Célia Mingroni‐Netto   +6 more
doaj   +1 more source

The cooperative regulation of miR‐221 by APE1 and AUF1 impacts p27Kip1 defining a miR signature relevant for cervical cancer

FEBS Open Bio, EarlyView.
A regulatory axis involving APE1, AUF1, and miR‐221 is proposed. Pri‐miR‐221 is processed by DROSHA and DICER to generate mature miR‐221, which targets p27Kip1 mRNA. APE1 and AUF1 compete for pre‐miR‐221 binding. Reduced APE1/AUF1 levels impair miR‐221 biogenesis, decrease p27Kip1 mRNA degradation, and promote cell cycle progression, chemoresistance ...
Matilde Clarissa Malfatti, Nicolò Gualandi, Gianluca Tell, Giulia Antoniali   +3 more
wiley   +1 more source

Reassessment of the evolution of wheat chromosomes 4A, 5A, and 7B. [PDF]

, 2018
Key messageComparison of genome sequences of wild emmer wheat and Aegilops tauschii suggests a novel scenario of the evolution of rearranged wheat chromosomes 4A, 5A, and 7B.
Deal, Karin R, Devos, Katrien M, Distelfeld, Assaf, Dvorak, Jan, Gill, Bikram S, Gu, Yong Q, Jorgensen, Chad M, Luo, Ming-Cheng, McGuire, Patrick E, Qi, Peng, Wang, Le, Zhu, Tingting   +11 more
core  

Dapagliflozin prevents methylglyoxal‐induced retinal cell death in ARPE‐19 cells

FEBS Open Bio, EarlyView.
Diabetic macular oedema is a diabetes complication of the eye, which may lead to permanent blindness. ARPE‐19 are human retinal cells used to study retinal diseases and potential therapeutics. Methylglyoxal is a compound increased in uncontrolled diabetes due to elevated blood glucose.
Naina Trivedi, Zainab Quraishi, Shima Khezri Azizi Far, Madaleine Ward, Aidan Conway, Reem Abdulredha, Eman Mshari, Yousif A. Shamsaldeen   +7 more
wiley   +1 more source