Results 121 to 130 of about 280,333 (306)
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson +13 morewiley +1 more sourceRegulation of nucleotide excision repair by UV-DDB: prioritization of damage recognition to internucleosomal DNA [PDF]
, 2011 How tightly packed chromatin is thoroughly inspected for DNA damage is one of the fundamental unanswered questions in biology. In particular, the effective excision of carcinogenic lesions caused by the ultraviolet (UV) radiation of sunlight depends on ...Naegeli, H, Nina Kaczmarek, Andreas Glas, Glas, Andreas, Carell Thomas, Glas, A, Carell, Thomas, Fei Jia, Kaczmarek Nina, Glas Andreas, Jia Fei, Carell, T, Andreas Luch, Naegeli Hanspeter, Fei, Jia, Naegeli, Hanspeter, Luch Andreas, Kaczmarek, Nina, Thomas Carell, Hanspeter Naegeli, Luch, A, Luch, Andreas, Fei, J, Kaczmarek, N +23 morecore +1 more sourceLarge-Scale Structural Variation Detection in Subterranean Clover Subtypes Using Optical Mapping
Frontiers in Plant Science, 2018 We selected two genetically diverse subspecies of the Trifolium model species, subterranean clover cvs. Daliak and Yarloop. The structural variations (SVs) discovered by Bionano optical mapping (BOM) were validated using Illumina short reads.Yuxuan Yuan, Yuxuan Yuan, Zbyněk Milec, Philipp E. Bayer, Philipp E. Bayer, Jan Vrána, Jaroslav Doležel, David Edwards, David Edwards, William Erskine, William Erskine, Parwinder Kaur, Parwinder Kaur, Parwinder Kaur +13 moredoaj +1 more sourceLoss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann +11 morewiley +1 more sourceFine-mapping identifies multiple prostate cancer risk loci at 5p15, one of which associates with TERT expression [PDF]
, 2013 Associations between single nucleotide polymorphisms (SNPs) at 5p15 and multiple cancer types have been reported. We have previously shown evidence for a strong association between prostate cancer (PrCa) risk and rs2242652 at 5p15, intronic in the ...Hayes, R B, Schumacher, Fredrick, Severi, G., Berndt, S.I., Key, Timothy, Berndt SI, Spurdle A, Dicks, E, Ingles, SA, Le Marchand L, Muir, K; id_orcid, Ingles, S., Albanes, D, Canzian, F., Cybulski, C., Easton DF, Riboli, E., Halim, Silvia, Govindasami, K, Muir, Ken, Conroy, Don, Thobodeau, S.N, Eeles RA, Vogel, W., Muir, K, Hamdy, Freddie C., Leongamornlert, DA, Bacot F, Guy, Michelle, Wilkinson, R.A., Dunning, A.M., Albanes, D., Benlloch, S, Russell R, Clements, Judith A., Key TJ, Al Olama AA, Pharoah P, Morgan, A., Tymrakiewicz, M., Travis RC, Lee, A., Benlloch, S., Hamdy, FC, Stanford, JL, Batra, J., Ingles, Sue A., John, EM, Berndt, Sonja I., Giles, Graham G., Hunter, D.J., Donovan, JL, Wilkinson RA, Thibodeau, Stephen N., Kibel AS, Dadaev T, Luccarini C, Khaw KT, Kraft, P., Gapstur, Susan, Vogel W, Park, Jong Y., Stanford, Janet L., Bojesen SE, Kaneva, Radka, Ostrander, Elaine A., Wilkinson, Rosemary A., Haiman, Christopher A., Batra, J, Ostrander, E A, John EM, Key, Tim J., Schleutker J, Haiman, C.A., Lubinski, Jan, Thibodeau, S N, Lindstrom, S, Schleutker, J, Tessier DC, Key, T J, Maier, C., Le Marchand, Loic, Dunning, AM, John, E.M., Easton, DF, Campa, D., Russel, R, Henderson BE, Ostrander, EA, Spurdle, A., Khaw, KT, Easton, D F, Kaneva, R., Henderson, B E, Hamdy FC, Muir, K.R., Vincent D, Russell, R, Donovan, Jenny, Kraft, P, Khaw, K-T, Clements JA, Guy M, Dennis, Joe, Marchand, LL, Gapstur, S., Sawyer, E.J., Neal, David E., Leongamornlert, D.A., John, Esther M., Albanes, Demetrius, Stanford, J.L., Jugurnauth-Little, Sarah, Kibel, AS, Schaid, D., Cybulski, C, Ingles SA, Govindasami, Koveela, Lubinski, J, Wiklund, F., Donovan JL, Riboli, E, Donovan, J L, Hayes RB, Gronberg, H, Hamdy, F.C., Batra, Jyotsna, Signorello, L.B., Ross Adams H, Campa, Daniele, Gapstur, S, Travis, Ruth, Neal, D E, Wilkinson, RA, Signorello, Lisa B., Key, T.J., Pharoah, P, Muir, Kenneth, Dennis, J, Ghoussaini, M., Lindstrom, S., Neal, DE, Hunter DJ, Dadaev, T, Bojesen, Stig E., Canzian, F, John, E M, Vincent, Daniel, Eeles, RA, Ostrander, E.A., Ross-Adams, Helen, Park JY, Park, JY, Saunders, EJ, Hamdy, F C, Dadaev, T., Baynes, C., Signorello, L B, Wilkinson, R A, Muir K, Bojesen, S E, Haiman CA, Saunders, E J, Baynes, Caroline, Dennis, J., Andriole G, Ross-Adams, H., Henderson, BE, Teixeira, M R, Baynes, C, Dennis J, Gronberg, Henrik, Sawyer EJ, Vincent, D., Campa, D, Saunders, E., Pharoah, Paul, Tessier, DC, Teixeira, M.R., Hunter, David J., Hunter, D J, Chanock, Stephen, Tymrakiewicz, M, Maier C, COGS CRUK GWAS ELLIPSE Initiative, Kaneva R, Travis, R C, Signorello, LB, Kote-Jarai, Z., Cybulski, Cezary, Baynes C, Donovan, J.L., Weischer, Maren, Park, J Y, Leongamornlert DA, Ostrander EA, Lubinski J, Luccarini, Craig, Dicks E, Cannon-Albright, L., Cannon-Albright, Lisa, Marchand, L L, Travis, Ruth C., Giles, GG, Ross-Adams, H, Pharoah, P., Giles, Graham, Kibel, Adam S., Kaneva, R, Neal DE, Khaw, Kay-Tee, Bacot, François, Haiman, CA, Teixeira, MR, Teixeira, Manuel R., Al Olama, AA, Giles, G G, Halim S, Key, TJ, Andriole, Gerald, Tessier, Daniel C., Benlloch, Sara, Conroy D, Hunter, DJ, Schumacher, F, Stanford JL, Schleutker, Johanna, Donovan, Jenny L., Brenner, H., Wiklund, F, Kraft, Peter, Brenner H, Al Olama, A A, Kaaks, Rudolf, Canzian F, Luccarini, C, Andriole, G, Clements, J., Canzian, Federico, Kaaks R, Conroy, D.K., Severi G, Park, J.Y., Severi, G, Signorello LB, Schleutker, J., Tymrakiewicz M, Cannon-Albright, L, Jugurnauth Little S, Bojesen, SE, Saunders EJ, Tessier, D.C., Riboli E, Spurdle, A, Bacot, F, Schaid D, Neal, D.E., Severi, Gianluca, Vincent, D, Henderson, Brian E., Vogel, Walther, Russel, Roslin, Ingles, S A, Albanes D, Khaw, K T, Batra J, Dunning AM, Gapstur S, Tessier, D C, Travis, RC, Morgan, Angela, PRACTICAL Consortium, Cybulski C, Weischer, M, Weischer M, Haiman, C A, Schaid, Dan, Conroy, D, Cannon Albright L, Bacot, F., Luccarini, C., Kote-Jarai, Zsofia, Sawyer, Emma J., Chanock, S, Maier, C, Teixeira MR, Chanock, S., UK Genetic Prostate Cancer Study Collaborators/British Association of Urological Surgeons' Section of Oncology, Gronberg, H., Vogel, W, Schumacher F, Kote-Jarai, Z, Brenner, H, Saunders, Edward J., Weischer, M., Govindasami, K., Wiklund F, Le Marchand, L., Kote Jarai Z, Benlloch S, Maier, Christiane, Guy, M, Easton, Douglas F., Amin Ali, A.L., Travis, R.C., Guy, M., Dadaev, Tokhir, Henderson, B.E., Tymrakiewicz, Malgorzata, Wiklund, Fredrik, Hayes, R.B., Govindasami K, Thibodeau, SN, Kibel, A S, UK ProtecT Study Collaborators, Clements, JA, Giles, G.G., Clements, J A, Thibodeau SN, Lubinski, J., Al Olama, Ali Amin, Kraft P, Russel, R., Jugurn-Little, S, Eeles, R A, Dunning, Alison M., Schaid, D, Stanford, J L, Berndt, SI, Chanock S, Eeles, R.A., Le Marchand, L, Leongamornlert, D A, Sawyer, E J, Andriole, G., Dicks, E., Easton, D.F., Giles GG, Pashayan, N., Hayes, Richard B., Lindstrom, Sara, Hamdy, Freddie, Kibel, A.S, Spurdle, Amanda, Morgan, A, Sawyer, EJ, Leongamornlert, Daniel A., Dicks, Ed, Morgan A, Brenner, Hermann, Gronberg H, Schumacher, F.R., Lindstrom S, Jugurnath-Little, S., Halim, S., Hayes, RB, Kaaks, R, Dunning, A M, Jugurnauth-Little, S, Eeles, Rosalind A., Halim, S, Berndt, S I +361 morecore +1 more sourcePromiscuous stimulation of HSP70 ATPase activity by parasite‐derived J‐domains
FEBS Open Bio, EarlyView.The malaria parasite Plasmodium falciparum exports three highly homologous yet functionally divergent J‐domain proteins into human erythrocytes. Here, we show that J‐domains isolated from all three proteins effectively stimulate the ATPase activity of both endogenous host and exported parasite HSP70 chaperones.Julian Barth, Moritz Koch, Le‐Han Rössner, Johanna Eichhorn, Denys Pogoryelov, Matthias P. Mayer, Jude M. Przyborski +6 morewiley +1 more sourceIncrease in Tomato Locule Number Is Controlled by Two
Single-Nucleotide Polymorphisms Located [PDF]
, 2011 In tomato (Solanum lycopersicum) fruit, the number of locules (cavities containing seeds that are derived from carpels) varies from two to up to 10 or more.Causse, Mathilde,, Mondher Bouzayen, Yolande Carretero, Le Paslier, Marie-Christine, Berard, Aurélie,, Corinne Delalande, Botton, Emmanuel, Delalande, Corinne, Rolland, Sophie, Philippe Duffé, Mathilde Causse, Emmanuel Botton, Berard, Aurélie, Duffe, Philippe, Sophie Rolland, Ranc, Nicolas,, Aurélie Bérard, Ranc, Nicolas, Carretero, Yolande, Brunel, Dominique, Dominique Brunel, Bouzayen, Mondher, Nicolas Ranc, Marie-Christine Le Paslier, Stéphane Muños, Brunel, Dominique,, Munos, Stéphane, Causse, Mathilde +27 morecore +1 more source
