Components of the Nucleotide Salvage Pathway Increase Frog Virus 3 (FV3) Replication [PDF]
Viruses, 2023 Viruses are obligate intracellular parasites that alter host metabolic machinery to obtain energy and macromolecules that are pivotal for replication.
Samantha R. Logan +3 more
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Metabolic constraint of human telomere length by nucleotide salvage efficiency [PDF]
Nature CommunicationsHuman telomere length is tightly regulated and associated with diseases at either extreme, but how these bounds are established remains incompletely understood.
William Mannherz +3 more
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Targeting the nucleotide salvage factor DNPH1 sensitizes <i>BRCA</i>-deficient cells to PARP inhibitors. [PDF]
Science, 2021 Three strikes to knock cancer out BRCA1 and BRCA2 are tumor-suppressor genes, and patients with mutations in these genes are predisposed to breast, ovarian, and other cancers.
Fugger K +13 more
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Nucleotide salvage deficiencies, DNA damage and neurodegeneration. [PDF]
Int J Mol Sci, 2015 Nucleotide balance is critically important not only in replicating cells but also in quiescent cells. This is especially true in the nervous system, where there is a high demand for adenosine triphosphate (ATP) produced from mitochondria. Mitochondria are particularly prone to oxidative stress-associated DNA damage because nucleotide imbalance can ...
Fasullo M, Endres L.
europepmc +6 more sources
The Effect of Two Weeks of High-intensity Interval Training on Salvage nucleotide pathway [PDF]
فیزیولوژی ورزش و فعالیت بدنی, 2022 Purpose: The effects of exercise adaptation on improving the purine nucleotides components are inevitable, and physical activity improves the purine nucleotide salvage pathway.
Abbas Ghanbari Niaki +1 more
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Vacuolar phosphatases are essential for efficient nucleotide salvage in Arabidopsis. [PDF]
J Exp BotAbstract The salvage pathway that recycles nucleotides from RNA is an important contributor to cellular homeostasis. In Arabidopsis, RNA salvage occurs in the vacuole, in a process started by RNS2. Defects in this pathway lead to constitutive autophagy.
Liu AY +4 more
europepmc +5 more sources
Nucleotide degradation and ribose salvage in yeast
Molecular Systems Biology, 2013 Nucleotide degradation is a universal metabolic capability. Here we combine metabolomics, genetics and biochemistry to characterize the yeast pathway.
Yi‐Fan Xu +9 more
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Manifestation of Heat-Induced Valuable Dietary Nucleotide Salvage in Food Prepared from Aged Fish in Fast Protein and Metabolites Liquid Chromatography, ATP-Bioluminescence Assay, and NMR Spectra [PDF]
AppliedChem, 2023 Dietary nucleotides and nucleosides, primarily inosine monophosphate (IMP) and the adenine nucleotide pool (ANP), are widely considered as essential nutrients responsible for multiple biological functions.
Alar Sünter +10 more
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Nucleoside salvage pathway kinases regulate hematopoiesis by linking nucleotide metabolism with replication stress [PDF]
Journal of Experimental Medicine, 2012 Nucleotide deficiency causes replication stress (RS) and DNA damage in dividing cells. How nucleotide metabolism is regulated in vivo to prevent these deleterious effects remains unknown. In this study, we investigate a functional link between nucleotide deficiency, RS, and the nucleoside salvage pathway (NSP) enzymes deoxycytidine kinase (dCK) and ...
Wayne R. Austin +10 more
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Helicobacter pylori Relies Primarily on the Purine Salvage Pathway for Purine Nucleotide Biosynthesis [PDF]
Journal of Bacteriology, 2011 ABSTRACT Helicobacter pylori is a chronic colonizer of the gastric epithelium and plays a major role in the development of gastritis, peptic ulcer disease, and gastric cancer. In its coevolution with humans, the streamlining of the H.
George W. Liechti, Joanna B. Goldberg
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