Components of the Nucleotide Salvage Pathway Increase Frog Virus 3 (FV3) Replication [PDF]
Viruses, 2023 Viruses are obligate intracellular parasites that alter host metabolic machinery to obtain energy and macromolecules that are pivotal for replication.
Samantha R. Logan +3 more
doaj +6 more sources
Metabolic constraint of human telomere length by nucleotide salvage efficiency [PDF]
Nature CommunicationsHuman telomere length is tightly regulated and associated with diseases at either extreme, but how these bounds are established remains incompletely understood.
William Mannherz +3 more
doaj +6 more sources
Nucleotide degradation and ribose salvage in yeast [PDF]
Molecular Systems Biology, 2013 Nucleotide degradation is a universal metabolic capability. Here we combine metabolomics, genetics and biochemistry to characterize the yeast pathway.
Yi‐Fan Xu +9 more
doaj +7 more sources
The Effect of Two Weeks of High-intensity Interval Training on Salvage nucleotide pathway [PDF]
فیزیولوژی ورزش و فعالیت بدنی, 2022 Purpose: The effects of exercise adaptation on improving the purine nucleotides components are inevitable, and physical activity improves the purine nucleotide salvage pathway.
Abbas Ghanbari Niaki +1 more
doaj +3 more sources
Targeting the nucleotide salvage factor DNPH1 sensitizes <i>BRCA</i>-deficient cells to PARP inhibitors. [PDF]
Science, 2021 Three strikes to knock cancer out BRCA1 and BRCA2 are tumor-suppressor genes, and patients with mutations in these genes are predisposed to breast, ovarian, and other cancers. Because BRCA1 and BRCA2 mutations affect pathways involved in DNA break
Fugger K +13 more
europepmc +6 more sources
Nucleotide salvage deficiencies, DNA damage and neurodegeneration. [PDF]
Int J Mol Sci, 2015 Nucleotide balance is critically important not only in replicating cells but also in quiescent cells. This is especially true in the nervous system, where there is a high demand for adenosine triphosphate (ATP) produced from mitochondria. Mitochondria are particularly prone to oxidative stress-associated DNA damage because nucleotide imbalance can ...
Fasullo M, Endres L.
europepmc +7 more sources
Manifestation of Heat-Induced Valuable Dietary Nucleotide Salvage in Food Prepared from Aged Fish in Fast Protein and Metabolites Liquid Chromatography, ATP-Bioluminescence Assay, and NMR Spectra [PDF]
AppliedChem, 2023 Dietary nucleotides and nucleosides, primarily inosine monophosphate (IMP) and the adenine nucleotide pool (ANP), are widely considered as essential nutrients responsible for multiple biological functions.
Alar Sünter +10 more
doaj +2 more sources
Ribose Supplementation Alone or with Elevated Creatine Does Not Preserve High Energy Nucleotides or Cardiac Function in the Failing Mouse Heart. [PDF]
PLoS ONE, 2013 BackgroundReduced levels of creatine and total adenine nucleotides (sum of ATP, ADP and AMP) are hallmarks of chronic heart failure and restoring these pools is predicted to be beneficial by maintaining the diseased heart in a more favourable energy ...
Kiterie M E Faller +6 more
doaj +14 more sources
The nucleobase analog 4-thiouracil hijacks the pyrimidine salvage pathway to inhibit Staphylococcus aureus growth [PDF]
Microbiology SpectrumStaphylococcus aureus is a leading cause of bacterial-induced mortality due to infections that are increasingly resistant to antibiotics, highlighting the need for new therapeutic strategies to treat these drug-resistant infections.
Matthew J. Munneke +2 more
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E. coli genetically modified for purine nucleobase release promotes butyrate generation and colonic wound healing during DSS insult [PDF]
Gut MicrobesThe gut microbiota transforms energy stored as undigestible carbohydrates into a remarkable number of metabolites that fuel intestinal bacterial communities and the host tissue.
J. Scott Lee +7 more
doaj +2 more sources