Results 1 to 10 of about 30,118 (199)

Components of the Nucleotide Salvage Pathway Increase Frog Virus 3 (FV3) Replication [PDF]

Viruses, 2023
Viruses are obligate intracellular parasites that alter host metabolic machinery to obtain energy and macromolecules that are pivotal for replication.
Samantha R. Logan, Mark Seegobin, R. J. Neil Emery, Craig R. Brunetti   +3 more
doaj   +4 more sources

Metabolic constraint of human telomere length by nucleotide salvage efficiency [PDF]

Nature Communications
Human telomere length is tightly regulated and associated with diseases at either extreme, but how these bounds are established remains incompletely understood.
William Mannherz, Andrew Crompton, Noah Lampl, Suneet Agarwal   +3 more
doaj   +4 more sources

Nucleotide degradation and ribose salvage in yeast [PDF]

Molecular Systems Biology, 2013
Nucleotide degradation is a universal metabolic capability. Here we combine metabolomics, genetics and biochemistry to characterize the yeast pathway.
Yi‐Fan Xu, Fabien Létisse, Farnaz Absalan, Wenyun Lu, Ekaterina Kuznetsova, Greg Brown, Amy A Caudy, Alexander F Yakunin, James R Broach, Joshua D Rabinowitz   +9 more
doaj   +2 more sources

Manifestation of Heat-Induced Valuable Dietary Nucleotide Salvage in Food Prepared from Aged Fish in Fast Protein and Metabolites Liquid Chromatography, ATP-Bioluminescence Assay, and NMR Spectra [PDF]

AppliedChem, 2023
Dietary nucleotides and nucleosides, primarily inosine monophosphate (IMP) and the adenine nucleotide pool (ANP), are widely considered as essential nutrients responsible for multiple biological functions.
Alar Sünter, Artur Kuznetsov, Piret Raudsepp, Tõnu Püssa, Lauri Toom, Georgii Konoplev, Oksana S. Stepanova, Oksana V. Stepanova, Daniil Lyalin, Aleksandr Frorip, Mati Roasto   +10 more
doaj   +2 more sources

Ribose Supplementation Alone or with Elevated Creatine Does Not Preserve High Energy Nucleotides or Cardiac Function in the Failing Mouse Heart. [PDF]

PLoS ONE, 2013
Reduced levels of creatine and total adenine nucleotides (sum of ATP, ADP and AMP) are hallmarks of chronic heart failure and restoring these pools is predicted to be beneficial by maintaining the diseased heart in a more favourable energy state.
Kiterie M E Faller, Debra J Medway, Dunja Aksentijevic, Liam Sebag-Montefiore, Jürgen E Schneider, Craig A Lygate, Stefan Neubauer   +6 more
doaj   +15 more sources

The Effect of Two Weeks of High-intensity Interval Training on Salvage nucleotide pathway [PDF]

فیزیولوژی ورزش و فعالیت بدنی, 2022
Purpose: The effects of exercise adaptation on improving the purine nucleotides components are inevitable, and physical activity improves the purine nucleotide salvage pathway.
Abbas Ghanbari Niaki, Rouhollah Haghshenas Gatabi   +1 more
doaj   +2 more sources

E. coli genetically modified for purine nucleobase release promotes butyrate generation and colonic wound healing during DSS insult [PDF]

Gut Microbes
The gut microbiota transforms energy stored as undigestible carbohydrates into a remarkable number of metabolites that fuel intestinal bacterial communities and the host tissue.
J. Scott Lee, Daniel J. Kao, Corey S. Worledge, Zachary F. Villamaria, Ruth X. Wang, Nichole M. Welch, Rachael E. Kostelecky, Sean P. Colgan   +7 more
doaj   +2 more sources

Targeting the nucleotide salvage factor DNPH1 sensitizes BRCA-deficient cells to PARP inhibitors. [PDF]

Science, 2021
Fugger K, Bajrami I, Silva Dos Santos M, Young SJ, Kunzelmann S, Kelly G, Hewitt G, Patel H, Goldstone R, Carell T, Boulton SJ, MacRae J, Taylor IA, West SC.   +13 more
europepmc   +3 more sources

Epileptic encephalopathy in a young Bengal cat caused by CAD deficiency [PDF]

Scientific Reports
Developmental and epileptic encephalopathy type 50 (DEE50) in humans is a severe early-onset neurometabolic disorder caused by biallelic loss-of-function variants in the CAD gene encoding a key multi-enzymatic protein for de novo pyrimidine nucleotide ...
Adriana Kaczmarska, Matthias Christen, Francisco del Caño-Ochoa, Santiago Ramon-Maiques, Ana Cloquell Miro, Angie Rupp, Vidhya Jagannathan, Tosso Leeb, Rodrigo Gutierrez-Quintana   +8 more
doaj   +2 more sources

mTORC1 regulates the pyrimidine salvage pathway by controlling UCK2 turnover via the CTLH-WDR26 E3 ligase [PDF]

Cell Reports
Summary: One critical aspect of cell proliferation is increased nucleotide synthesis, including pyrimidines. Pyrimidines are synthesized through de novo and salvage pathways.
Brittany Q. Pham, Sang Ah Yi, Alban Ordureau, Heeseon An   +3 more
doaj   +2 more sources