Results 91 to 100 of about 14,893 (257)

Ribose Supplementation Alone or with Elevated Creatine Does Not Preserve High Energy Nucleotides or Cardiac Function in the Failing Mouse Heart.

open access: yesPLoS ONE, 2013
BackgroundReduced levels of creatine and total adenine nucleotides (sum of ATP, ADP and AMP) are hallmarks of chronic heart failure and restoring these pools is predicted to be beneficial by maintaining the diseased heart in a more favourable energy ...
Kiterie M E Faller   +6 more
doaj   +1 more source

Hydrogel‐Based Smart Materials for Wound Healing and Sensing

open access: yesAggregate, EarlyView.
The graphical abstract illustrates the role of hydrogel‐based flexible materials in advancing biomedical applications, including wound healing, point‐of‐care diagnostics, smart patches, and wearable devices. Hydrogels are particularly promising in modern wound care due to their high‐water content, flexibility, and biocompatibility.
Thi Kim Ngan Duong   +11 more
wiley   +1 more source

Control of ATP homeostasis during the respiro‐fermentative transition in yeast

open access: yesMolecular Systems Biology, 2010
Respiring Saccharomyces cerevisiae cells respond to a sudden increase in glucose concentration by a pronounced drop of their adenine nucleotide content ([ATP]+[ADP]+[AMP]=[AXP]).
Thomas Walther   +6 more
doaj   +1 more source

Autofluorescence Imaging and Virtual Histological Staining of Human Prostate Sections for Cancer Diagnosis

open access: yesAdvanced Intelligent Systems, EarlyView.
Autofluorescence imaging with virtual histological staining streamlines postoperative histopathology. Using a deep ultraviolet light‐emitting diode (LED)‐based imaging system and a weakly supervised deep learning model, virtual hematoxylin and eosin (H&E)‐stained images are generated from the autofluorescence of prostate tissue. Pathologist evaluations
Mingxuan Si   +9 more
wiley   +1 more source

Metabolic Regulation as a Consequence of Anaerobic 5-Methylthioadenosine Recycling in Rhodospirillum rubrum

open access: yesmBio, 2016
Rhodospirillum rubrum possesses a novel oxygen-independent, aerobic methionine salvage pathway (MSP) for recycling methionine from 5-methylthioadenosine (MTA), the MTA-isoprenoid shunt.
Justin A. North   +7 more
doaj   +1 more source

Phylogenetic relationships and the identification of allopolyploidy in circumpolar Silene sect. Physolychnis

open access: yesAmerican Journal of Botany, EarlyView.
Abstract Premise Species complexes are groups of closely related species with ambiguous delimitation, often composed of recently diverged lineages. Polyploidization and uniparental reproduction (i.e., selfing and apomixis) can play important roles in the origin of species complexes. These complexes pose challenges for species‐based scientific questions,
Anne‐Sophie Quatela   +7 more
wiley   +1 more source

Thymidine kinase 1 through the ages: a comprehensive review

open access: yesCell & Bioscience, 2020
Proliferation markers, such as proliferating cell nuclear antigen (PCNA), Ki-67, and thymidine kinase 1 (TK1), have potential as diagnostic tools and as prognostic factors in assessing cancer treatment and disease progression. TK1 is involved in cellular
Eliza E. Bitter   +4 more
doaj   +1 more source

Perspectives on the Current and Future State of Artificial Intelligence in Medical Genetics

open access: yesAmerican Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Artificial intelligence (AI) is rapidly transforming numerous aspects of daily life, including clinical practice and biomedical research. In light of this rapid transformation, and in the context of medical genetics, we assembled a group of leaders in the field to respond to the question about how AI is affecting, and especially how AI will ...
Benjamin D. Solomon   +20 more
wiley   +1 more source

Nicotinamide Mononucleotide: Exploration of Diverse Therapeutic Applications of a Potential Molecule

open access: yesBiomolecules, 2019
Nicotinamide mononucleotide (NMN) is a nucleotide that is most recognized for its role as an intermediate of nicotinamide adenine dinucleotide (NAD+) biosynthesis.
Saikat Kumar Poddar   +5 more
doaj   +1 more source

SIRT4 loss reprograms intestinal nucleotide metabolism to support proliferation following perturbation of homeostasis

open access: yesCell Reports
Summary: The intestine is a highly metabolic tissue, but the metabolic programs that influence intestinal crypt proliferation, differentiation, and regeneration are still emerging.
Sarah A. Tucker   +9 more
doaj  

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