Results 131 to 140 of about 30,194 (292)
Nicotinamide Mononucleotide: Exploration of Diverse Therapeutic Applications of a Potential Molecule
Biomolecules, 2019 Nicotinamide mononucleotide (NMN) is a nucleotide that is most recognized for its role as an intermediate of nicotinamide adenine dinucleotide (NAD+) biosynthesis.
Saikat Kumar Poddar +5 more
doaj +1 more source
Advanced Science, EarlyView.This work unravels a novel function of CD103+ T cells in eradicating oxidative‐stressed somatic cells to prevent lung tumorigenesis and identifies specific CD103+ T cell‐decline as a key feature in the aged lung. This comprehensive study highlights the contribution of immuno‐dysregulation to the high incidence of aging‐associated lung cancers ...
Yu Xu +7 more
wiley +1 more source
Multi‐Omics and ‐Organ Insights into Energy Metabolic Adaptations in Early Sepsis Onset
Advanced Science, EarlyView.This study shows that patients at risk of sepsis have a distinct metabolite and lipid signature, including serine and aminoadipic acid, in their serum before clinical diagnosis. A mouse model of sepsis with a compatible serum signature reveals underlying metabolic changes, including mitochondrial adaptation, altered serine‐dependent purine metabolism ...
Lin‐Lin Xu +9 more
wiley +1 more source
Peptide Hormone‐Mediated Regulation of Plant Development and Environmental Adaptability
Advanced Science, EarlyView.In this review, recent advances in understanding the roles of plant peptide hormones in regulating growth, reproduction, and environmental adaptability are systematically summarized. It further elucidates the challenges in studying these peptides, such as their low abundance, functional redundancy, and complex signaling mechanisms, and highlights their
Xin Li +8 more
wiley +1 more source
, 2018 Orotic acid is an intermediate found in the pathway for pyrimidine synthesis. The mitochondrial enzyme dihydroorotate dehydrogenase (DHODH) catalyzes the production of orotic acid by the conversion of the compound dihydroorotate to orotic acid.
Fonteh, Aliah L
core +1 more source
De Novo Pyrimidine Nucleotide Synthesis Mainly Occurs outside of Plastids, but a Previously Undiscovered Nucleobase Importer Provides Substrates for the Essential Salvage Pathway in Arabidopsis [PDF]
, 2012 Sandra Witz +3 more
openalex +1 more source
Advanced Intelligent Systems, EarlyView.Autofluorescence imaging with virtual histological staining streamlines postoperative histopathology. Using a deep ultraviolet light‐emitting diode (LED)‐based imaging system and a weakly supervised deep learning model, virtual hematoxylin and eosin (H&E)‐stained images are generated from the autofluorescence of prostate tissue. Pathologist evaluations
Mingxuan Si +9 more
wiley +1 more source
, 2004 Intracellular symbiosis is very common in the insect world. For the aphid Cinara cedri, we have identified by electron microscopy three symbiotic bacteria that can be characterized by their different sizes, morphologies, and electrodensities.
García-Verdugo, José Manuel +6 more
core +2 more sources
Mainstream Artificial Intelligence Technologies in Contemporary Ophthalmology
Advanced Intelligent Systems, EarlyView.This review explores the latest artificial intelligence (AI) technologies in ophthalmology, focusing on four key data types: medical imaging, electronic health records, robotic‐assisted surgery, and genomics. It examines the structural features, use cases, clinical goals, and evaluation metrics of various AI algorithms, while also introducing emerging ...
Shiqi Yin +9 more
wiley +1 more source
American Journal of Botany, EarlyView.Abstract Premise Research on neutral and adaptive processes that lead to the divergence of species and populations is a crucial component in evolutionary and conservation genetics. Agave sobria is an endemic group of subspecies scattered on canyons along a latitudinal gradient and distinct environments of the Baja California Peninsula, Mexico.
Anastasia Klimova +4 more
wiley +1 more source