Results 181 to 190 of about 30,194 (292)

Supersulfide biology and translational medicine for disease control

British Journal of Pharmacology, EarlyView., 2023
Abstract For decades, the major focus of redox biology has been oxygen, the most abundant element on Earth. Molecular oxygen functions as the final electron acceptor in the mitochondrial respiratory chain, contributing to energy production in aerobic organisms. In addition, oxygen‐derived reactive oxygen species including hydrogen peroxide and nitrogen
Uladzimir Barayeu, Tomohiro Sawa, Motohiro Nishida, Fan‐Yan Wei, Hozumi Motohashi, Takaaki Akaike   +5 more
wiley   +1 more source

Landscape of targets within nucleoside metabolism for the modification of immune responses. [PDF]

Front Oncol
Dunderdale EM, Abt ER.
europepmc   +1 more source

Effects of SADS‐CoV accessory proteins NS3a, NS7a, and NS7b on viral pathogenicity: A multi‐omics investigation

iMetaOmics, EarlyView.
This study has elucidated the role of three swine acute diarrhea syndrome coronavirus (SADS‐CoV) accessory proteins in influencing viral pathogenicity and preliminarily explored the host molecular targets and pathways affected by the NS3a, NS7a, and NS7b proteins of SADS‐CoV.
Xiaoling Yan, Xiaoli Zhang, Ling Zhou, Xiaoya Zhao, Qianniu Li, Tian Lan, Jun Fu, Jingyun Ma   +7 more
wiley   +1 more source

Identification of picornavirus proteins that inhibit de novo nucleotide synthesis during infection. [PDF]

PLoS Pathog
Nouwen LV, Zaal EA, Buitendijk I, Zwaagstra M, Aloise C, van Vliet ALW, Schipper JG, van Mil A, Berkers CR, van Kuppeveld FJM.   +9 more
europepmc   +1 more source

Single bolus injection of nicotinamide mono nucleotide increases systemic insulin sensitivity in association with activation of NAD salvage pathway in the liver and adipose tissue in mice

Shunsuke Hiroshige, Yasuko Kajimura, Yuko Nagao, Akihiko Taguchi, Ryoko Hatanaka, Chika Yodokawa, Yuka Fujioka, Masaru Akiyama, Yukio Tanizawa, Yasuharu Ohta   +9 more
openalex   +1 more source

Salvage and de novo synthesis of nucleotides in Trypanosoma brucei and mammalian cells

, 2008
All living cells are dependent on nucleic acids for their survival. The genetic information stored in DNA is translated into functional proteins via a messenger molecule, the ribonucleic acid (RNA). Since DNA and RNA can be considered as polymers of nucleotides (NTPs), balanced pools of NTPs are crucial to nucleic acid synthesis and repair. The de novo
openaire   +1 more source

The impact of a high‐fat diet on liver health in pregnant mice and their offspring: The role of the gut‐liver axis

iMetaOmics, EarlyView.
The study investigated the longitudinal effects of normal and high‐fat diet, showing their differential effects on gut microbiota diversity and gut metabolites, with the latter having a significant impact on increasing liver inflammation and gut microbiota and metabolites disruption.
Qian Gong, Yufei Zhang, Juxiong Liu, Shuai Yuan, Huijie Hu, Yu Cao, Shoupeng Fu, Wenjin Guo   +7 more
wiley   +1 more source

Aneuploidy generates enhanced nucleotide dependency and sensitivity to metabolic perturbation. [PDF]

Genes Dev
Magesh RY, Kaur AN, Keller FN, Frederick A, Tseyang T, Haley JA, Rivera-Nieves AM, Liang AC, Guertin DA, Spinelli JB, Elledge SJ, Watson EV.   +11 more
europepmc   +1 more source

BioMGCore: A toolkit for detection of biological metabolites in microbiome

iMetaOmics, EarlyView.
The keyword matching and gene proximity principles were used to accurately identify core gene clusters in microbial genomes. The metabolic gene clusters can be classified into different taxonomic groups according to Domain, Phylum, Class, Order, Family, Genus, and Species. BioMGCore can achieve batch statistics for secondary metabolites prediction.
Guang Yang, Guohao Yu, Qian Cui, Xueping Huang, Kexin Guo, Shulei Jia   +5 more
wiley   +1 more source

Phage‐mediated horizontal transfer of Salmonella enterica virulence genes with regulatory feedback from the host

iMeta, EarlyView.
In this study, we found evidence of phage‐mediated horizontal transfer of virulence genes in Salmonella enterica in global habitats from a molecular evolutionary perspective. Notably, csrA, a global regulator in Salmonella enterica, curbed horizontal gene transfer by inhibiting the cyclization and release of prophage.
Tianjing She, Demeng Tan, Jose Luis Balcazar, Ville‐Petri Friman, Danrui Wang, Dong Zhu, Mao Ye, Mingming Sun, Shujian Yuan, Feng Hu   +9 more
wiley   +1 more source