Results 181 to 190 of about 14,893 (257)

DNA Hanger: Surface‐Minimized Single‐Molecule Immunoassay Platform

Small, EarlyView.
The DNA Hanger platform suspends long DNA molecules biotinylated along their length away from the surface, effectively minimizing nonspecific protein binding. The assay achieves high sensitivity and specificity in single‐molecule FLISA down to subpicomolar levels.
Jincheol Seol, Byungju Kim, Eui‐Sang Yu, Cherlhyun Jeong, Jong‐Bong Lee   +4 more
wiley   +1 more source

A cytidine deaminase-like protein modulates pyrimidine nucleotide homeostasis in Trypanosoma brucei. [PDF]

Sci Rep
Moro-Bulnes A, Bosch-Navarrete C, Antequera-Parrilla P, Castanys S, Vidal AE, Ruiz-Pérez LM, Pérez-Moreno G, González-Pacanowska D, Pacanowska DG, Moreno GP.   +9 more
europepmc   +1 more source

Acute kidney injury and iron metabolism: A narrative review focusing on pathophysiology and therapy

Smart Molecules, EarlyView.
Schematic illustration of acute kidney injury and iron metabolism (By Figdraw). Image for iron metabolism, including uptake, storage, utilization, export: Reproduced with permission. Abstract Acute kidney injury (AKI) represents a substantial challenge to public health and is characterized by elevated occurrence and fatality rates.
Xinyu Tan, Man Li, Jing Chen, Gang Liu, Zhixiang Lu   +4 more
wiley   +1 more source

Native and Engineered Extracellular Vesicles for the Treatment of Acute Lung Injury and Acute Respiratory Distress Syndrome

Small Science, EarlyView.
Both native and engineered extracellular vesicles (EVs) are served as promising therapeutic agents for treating acute lung injury (ALI) and acute respiratory distress syndrome (ARDS). To circumvent the limitations of native EVs, various engineering strategies are adopted.
Zhengyan Gu, Wenjun Xue, Guanchao Mao, Zhipeng Pei, Jingjing Li, Mingxue Sun, Xinkang Zhang, Shanshan Zhang, Songling Li, Jinfeng Cen, Kai Xiao, Ying Lu, Qingqiang Xu   +12 more
wiley   +1 more source

Metabolic Rewiring in the Face of Genomic Assault: Integrating DNA Damage Response and Cellular Metabolism. [PDF]

Biomolecules
Ma W, Zhou S.
europepmc   +1 more source

How We Simulate DNA Origami

Small Methods, EarlyView.
This tutorial provides a detailed step‐by‐step description on how to import DNA origami designs into the oxDNA model and characterize the origami's properties (such as equilibrium shape and flexibility) in simulations using free webservers oxView.org and oxDNA.org.
Sarah Haggenmueller, Michael Matthies, Matthew Sample, Petr Šulc   +3 more
wiley   +1 more source

Dimeric DNA Aptamers for the Spike Protein of SARS‐CoV‐2 Derived from a Structured Library with Dual Random Domains

Small Methods, EarlyView.
Dimeric in a single go: A novel DNA aptamer library has been designed to yield dimeric aptamers in a single in vitro selection. Tested against the SARS‐CoV‐2 spike protein, this dual random domain (DRD) library with two 25‐nucleotide random regions and a 20‐nucleotide poly‐thymidine linker produced high‐affinity dimeric aptamers with KD values as low ...
Ryan Amini, Jian Ma, Zijie Zhang, Qing Wang, Jimmy Gu, Leyla Soleymani, Yingfu Li   +6 more
wiley   +1 more source

Corrinoid salvaging and cobamide remodeling in bacteria and archaea. [PDF]

J Bacteriol
Villa EA, Escalante-Semerena JC.
europepmc   +1 more source

Exosome‐Based Theranostic for Gastrointestinal Cancer: Advances in Biomarker Discovery and Therapeutic Engineering

Small Methods, EarlyView.
This review explores the dual roles of exosomes in gastrointestinal (GI) cancers as diagnostic biomarkers and therapeutic agents. It highlights advancements in exosomal miRNAs, lncRNAs, circRNAs, and proteins for cancer detection and prognosis. The study also examines engineering strategies for exosome‐based drug delivery systems, their potential to ...
Mohit J. Mehta, Dongjun Shin, Hyun Sung Park, Jun Su An, Seong Il Lim, Hyun Jin Kim, Seungpyo Hong, Jiyoon Bu   +7 more
wiley   +1 more source

GSK3 coordinately regulates mitochondrial activity and nucleotide metabolism in quiescent oocytes. [PDF]

Biol Open
Eller L, Wang L, Gok MO, Hocaoglu H, Qin S, Gupta P, Sieber MH.   +6 more
europepmc   +1 more source