Genetic ablation of purine salvage in Cryptosporidium parvum reveals nucleotide uptake from the host cell [PDF]
Proceedings of the National Academy of Sciences, 2019 The apicomplexan parasite Cryptosporidium is a leading global cause of severe diarrheal disease and an important contributor to early-childhood mortality. Waterborne outbreaks occur frequently, even in countries with advanced water treatment capabilities, and there is currently no fully effective treatment ...
Cuny, Gregory D. +7 more
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Salvage enzymes in nucleotide biosynthesis [PDF]
, 2007 Balanced pools of deoxyribonucleoside triphosphates (dNTPs), the building blocks of DNA, and ribonucleoside triphosphates (NTPs), the precursors of RNA, are crucial for a controlled cell proliferation.
Kosinska, Urszula
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Epileptic encephalopathy in a young Bengal cat caused by CAD deficiency [PDF]
Scientific ReportsDevelopmental and epileptic encephalopathy type 50 (DEE50) in humans is a severe early-onset neurometabolic disorder caused by biallelic loss-of-function variants in the CAD gene encoding a key multi-enzymatic protein for de novo pyrimidine nucleotide ...
Adriana Kaczmarska +8 more
doaj +2 more sources
Nucleotide metabolism in Lactococcus lactis: salvage pathways of exogenous pyrimidines [PDF]
Journal of Bacteriology, 1994 By measuring enzyme activities in crude extracts and studying the effect of toxic analogs (5-fluoropyrimidines) on cell growth, the metabolism of pyrimidines in Lactococcus lactis was analyzed. Pathways by which uracil, uridine, deoxyuridine, cytidine, and deoxycytidine are metabolized in L. lactis were established.
Jan Martinussen +2 more
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Uridine Ribohydrolase and the Balance between Nucleotide Degradation and Salvage [PDF]
The Plant Cell, 2009 Nucleotides are ubiquitous in metabolism: in addition to being components of DNA and RNA, and the currency of energy metabolism in the cell, they also are formed into essential coenzymes, secondary metabolites, and plant hormones (reviewed in [Zrenner et al., 2006][1]).
Jennifer Mach
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A plastid nucleoside kinase is involved in inosine salvage and control of purine nucleotide biosynthesis [PDF]
The Plant Cell, 2022 AbstractIn nucleotide metabolism, nucleoside kinases recycle nucleosides into nucleotides—a process called nucleoside salvage. Nucleoside kinases for adenosine, uridine, and cytidine have been characterized from many organisms, but kinases for inosine and guanosine salvage are not yet known in eukaryotes and only a few such enzymes have been described ...
Xiaoguang Chen +3 more
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Borrelia burgdorferi uridine kinase: an enzyme of the pyrimidine salvage pathway for endogenous use of nucleotides [PDF]
FEMS Microbiology Letters, 2006 The 621 bp udk gene encoding Borrelia burgdorferi potential uridine kinase, involved in the pyrimidine salvage pathway, was cloned and sequenced. The B burgdorferi protein has a molecular mass of 24 kDa in sodium dodecyl sulfate-polyacrylamide gel.
Caroline Boursaux‐Eude +4 more
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Nucleoside salvage pathway kinases regulate hematopoiesis by linking nucleotide metabolism with replication stress [PDF]
Journal of Experimental Medicine, 2012 Nucleotide deficiency causes replication stress (RS) and DNA damage in dividing cells. How nucleotide metabolism is regulated in vivo to prevent these deleterious effects remains unknown. In this study, we investigate a functional link between nucleotide deficiency, RS, and the nucleoside salvage pathway (NSP) enzymes deoxycytidine kinase (dCK) and ...
Wayne R. Austin +10 more
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Importance Of Pyrimidine Nucleotide Salvage Pathways For Dna Synthesis In Skin
Journal of Investigative Dermatology, 1976 Split-thickness rabbit skins were minced and incubated in vitro with radioactive precursors selected to measure do novo and salvage pathways for pyrimidine nucleotide synthesis. In this system, both the salvage precursors [3H]thymidine and [14C]cytidine were incorporated actively into skin DNA and only [14C]cytidine into skin RNA.
Neil W. DeLapp, Marvin A. Karasek
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Helicobacter pylori Relies Primarily on the Purine Salvage Pathway for Purine Nucleotide Biosynthesis [PDF]
Journal of Bacteriology, 2011 ABSTRACT Helicobacter pylori is a chronic colonizer of the gastric epithelium and plays a major role in the development of gastritis, peptic ulcer disease, and gastric cancer. In its coevolution with humans, the streamlining of the H.
George W. Liechti, Joanna B. Goldberg
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