Nucleotide metabolism in Lactococcus lactis: salvage pathways of exogenous pyrimidines [PDF]
Journal of Bacteriology, 1994 By measuring enzyme activities in crude extracts and studying the effect of toxic analogs (5-fluoropyrimidines) on cell growth, the metabolism of pyrimidines in Lactococcus lactis was analyzed. Pathways by which uracil, uridine, deoxyuridine, cytidine, and deoxycytidine are metabolized in L. lactis were established.
Jan Martinussen +2 more
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Synthesis, Salvage, and Catabolism of Uridine Nucleotides in Boron-Deficient Squash Roots [PDF]
Plant Physiology, 1981 Previous work has provided evidence that plants may require boron to maintain adequate levels of pyrimidine nucleotides, suggesting that the state of boron deficiency may actually be one of pyrimidine starvation. Since the availability of pyrimidine nucleotides is influenced by their rates of synthesis, salvage, and catabolism, we compared these ...
Carol J. Lovatt +2 more
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Genetic ablation of purine salvage in Cryptosporidium parvum reveals nucleotide uptake from the host cell [PDF]
Proceedings of the National Academy of Sciences, 2019 The apicomplexan parasite Cryptosporidium is a leading global cause of severe diarrheal disease and an important contributor to early-childhood mortality. Waterborne outbreaks occur frequently, even in countries with advanced water treatment capabilities, and there is currently no fully effective treatment ...
Mattie C. Pawlowic +7 more
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Uridine Ribohydrolase and the Balance between Nucleotide Degradation and Salvage [PDF]
The Plant Cell, 2009 Nucleotides are ubiquitous in metabolism: in addition to being components of DNA and RNA, and the currency of energy metabolism in the cell, they also are formed into essential coenzymes, secondary metabolites, and plant hormones (reviewed in [Zrenner et al., 2006][1]).
Jennifer Mach
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Borrelia burgdorferi uridine kinase: an enzyme of the pyrimidine salvage pathway for endogenous use of nucleotides [PDF]
FEMS Microbiology Letters, 2006 The 621 bp udk gene encoding Borrelia burgdorferi potential uridine kinase, involved in the pyrimidine salvage pathway, was cloned and sequenced. The B burgdorferi protein has a molecular mass of 24 kDa in sodium dodecyl sulfate-polyacrylamide gel.
Caroline Boursaux‐Eude +4 more
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LOW ADENINE NUCLEOTIDE POOLS IN BLOOM'S SYNDROME MAY REFLECT A DEFECTIVE SALVAGE PURINE BIOSYNTHESIS: 126 [PDF]
Pediatric Research, 1985 A nucleotide analysis of Bloom's syndrome lymphocytes and fibroblasts has revealed a partial depletion in adenine nucleotide pools. ATP/ADP ratio in these cells was at least three-fold lower than in primary cultures of normal human cells. Fractionation of each adenine nucleotide by high performance liquid chromatography showed that differences did not ...
Héctor Martínez-Valdez +3 more
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Chronological lifespan extension and nucleotide salvage inhibition in yeast by isonicotinamide supplementation [PDF]
, 2021 AbstractIsonicotinamide (INAM) is an isomer of the NAD+precursor nicotinamide (NAM) that stimulates the enzymatic activity of Sir2, an NAD+-dependent histone deacetylase from the budding yeast,Saccharomyces cerevisiae. Supplementing INAM into growth media promotes the replicative lifespan (RLS) of this single cell organism by maintaining intracellular ...
Agata Kalita +9 more
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Impact of the Warburg effect on nucleotide homeostasis in human retinal endothelial cells and its relevance to proliferative diabetic retinopathy [PDF]
Frontiers in PharmacologyPurposeWhile great progress has been made in screening methods and therapies for proliferative diabetic retinopathy (PDR), it is still a major cause of blindness.
Andrew Gregory +14 more
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GDP‐fucose transporter SLC35C1: a potential regulatory role in cytosolic GDP‐fucose and fucosylated glycan synthesis [PDF]
FEBS Open BioGlycosylation occurs mainly in the Golgi apparatus, whereas the synthesis of nucleotide sugars occurs in the cytoplasm or nucleus. GDP‐fucose in mammalian cells could be produced via de novo and salvage pathways in the cytoplasm; the first one is ...
Edyta Skurska, Mariusz Olczak
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The Plant Cell, 2022 AbstractIn nucleotide metabolism, nucleoside kinases recycle nucleosides into nucleotides—a process called nucleoside salvage. Nucleoside kinases for adenosine, uridine, and cytidine have been characterized from many organisms, but kinases for inosine and guanosine salvage are not yet known in eukaryotes and only a few such enzymes have been described ...
Xiaoguang Chen +3 more
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