Results 201 to 210 of about 14,893 (257)

Intracellular accumulation of free cholesterol in macrophages triggers a PARP1 response to DNA damage and PARP1 impairs lipopolysaccharide-induced inflammatory response. [PDF]

PLoS One
Ting KKY, Ibrahim HM, Gulati N, Wang Y, Rocheleau JV, Cybulsky MI.   +5 more
europepmc   +1 more source

CCS‐Consensuser: A Haplotype‐Aware Consensus Generator for PacBio Amplicon Sequences

Molecular Ecology Resources, EarlyView.
ABSTRACT DNA sequencing technology has undergone substantial improvements in recent years, to the extent that Third Generation Sequencing platforms are capable of massively generating long‐reads. Amplicon sequencing has been among the most popular techniques due to its wide application in diverse fields of biological sciences.
Carlos Congrains, Forest Bremer, Julian R. Dupuis, Norman B. Barr, Ivonne J. Garzón‐Orduña, Daniel Rubinoff, Camiel Doorenweerd, Michael San Jose, Kimberley Morris, Angela Kauwe, Scott Geib   +10 more
wiley   +1 more source

Serine starvation suppresses the progression of esophageal cancer by regulating the synthesis of purine nucleotides and NADPH. [PDF]

Cancer Metab
Jie H, Wei J, Li Z, Yi M, Qian X, Li Y, Liu C, Li C, Wang L, Deng P, Liu L, Cen X, Zhao Y.   +12 more
europepmc   +1 more source

Optimization and Evaluation of the bestRAD Sequencing Approach: Towards Ascertainment of the Invasion Routes of the Oriental Fruit Fly, Bactrocera dorsalis

Molecular Ecology Resources, EarlyView.
ABSTRACT The bestRAD technique is a reduced genome representation approach with high‐capacity sample multiplexing and physical isolation of biotin‐labelled target DNA fragments using streptavidin beads, which should reduce total cost and genotyping errors. While we here formalise the relevance of this approach within the HTS landscape, our foremost aim
Emeline Charbonnel, Laure Benoit, Sabine Nidelet, Enrique Ortega‐Abboud, Bernhard Gschloessl, Raphaël Leblois, David Ouvrard, Marie‐Pierre Chapuis   +7 more
wiley   +1 more source

Unraveling Venetoclax Resistance: Navigating the Future of HMA/Venetoclax-Refractory AML in the Molecular Era. [PDF]

Cancers (Basel)
Chatzilygeroudi T, Karantanos T, Pappa V.   +2 more
europepmc   +1 more source

Phosphorylation of an RNA‐Binding Protein Rck/Me31b by Hippo Is Essential for Adipose Tissue Aging

Aging Cell, EarlyView.
Evolutionary conserved Hippo/Mst1 signaling non‐canonically regulates the stability of mRNAs through directly phosphorylating a subset of RNA binding proteins to stabilize lipolytic mRNAs. Hpo pathway contributes to the regulation of Drosophila lifespan by modulating the expression and activity of Me31b/RCK, which subsequently affects mRNA levels of ...
Eunbyul Yeom, Hyejin Mun, Jinhwan Lim, Yoo Lim Chun, Kyung‐Won Min, Johana Lambert, L. Ashley Cowart, Jason S. Pierce, Besim Ogretmen, Jung‐Hyun Cho, Jeong Ho Chang, J. Ross Buchan, Jason Pitt, Matt Kaeberlein, Sung‐Ung Kang, Eun‐Soo Kwon, Seungbeom Ko, Kyoung‐Min Choi, Yong Sun Lee, Yoon‐Su Ha, Seung‐Jin Kim, Kwang‐Pyo Lee, Hyo‐Sung Kim, Seo Young Yang, Chang Hoon Shin, Je‐Hyun Yoon, Kyu‐Sun Lee   +26 more
wiley   +1 more source

Environmental purines decrease Pseudomonas aeruginosa biofilm formation by disrupting c-di-GMP metabolism. [PDF]

Cell Rep
Kennelly C, Tran P, Prindle A.
europepmc   +1 more source

Incorporating familial risk, lifestyle factors, and pharmacogenomic insights into personalized noncommunicable disease (NCD) reports for healthcare funder beneficiaries participating in the Open Genome Project

Annals of Human Genetics, EarlyView.
Abstract Introduction An ethics‐guided decision‐making framework was developed for applying pathology‐supported genetic testing, a multifaceted pharmacodiagnostic approach that translates population risk stratification into clinical utility. We introduce this service, supported by the Open Genome Project, which aligns with the beneficence principle in ...
Manie De Klerk, Nicole Van Der Merwe, Johny Erasmus, Lindiwe Whati, Kelebogile E. Moremi, Daniel W. Olivier, Maritha J. Kotze   +6 more
wiley   +1 more source

Uridine-sensitized screening identifies genes and metabolic regulators of nucleotide synthesis

Strefeler A, Baker ZN, Chollet S, Guerra RM, Ivanisevic J, Gallart-Ayala H, Pagliarini DJ, Jourdain AA.   +7 more
europepmc   +1 more source

A genome-wide investigation of <i>Mycoplasma hominis</i> genes associated with gynecological infections or infertility. [PDF]

Front Microbiol
Chibani S, Yacoub E, Boujemaa S, Mardassi H, Guglielmini J, Vaysse A, Khadraoui N, Mlik B, Ben Abdelmoumen Mardassi B.   +8 more
europepmc   +1 more source