Results 211 to 220 of about 30,194 (292)

Histidine Decapeptide‐Incorporating Lipid Nanoparticles with Low Ionizable Lipids Proportion for Efficient Small Interfering RNA Delivery

Macromolecular Bioscience, EarlyView.
Following optimization of ionizable lipid proportion via cost‐efficient vortex‐mixing method, lipid nanoparticles (LNPs) with a lower ionizable lipid proportion (27.72%), termed LNP5, are fabricated with histidine decapeptide (His10) during formulation via microfluidic mixing method. His10‐incorporated LNP5 (LNP5H) exhibited a 1.6‐fold increase in gene
Yeonho Bae, Hyeondo Lee, Jun Hyuk Lee, Sangho Yeo, Hyejung Mok   +4 more
wiley   +1 more source

Patient-derived organotypic tissue cultures as a platform to evaluate metabolic reprogramming in breast cancer patients. [PDF]

J Biol Chem
Fan TW, Yan J, Goncalves CFL, Islam JMM, Lin P, Kaddah MMY, Higashi RM, Lane AN, Wang X, Zhu C.   +9 more
europepmc   +1 more source

Mass Spectrometry Structural Proteomics Enabled by Limited Proteolysis and Cross‐Linking

Mass Spectrometry Reviews, EarlyView.
ABSTRACT The exploration of protein structure and function stands at the forefront of life science and represents an ever‐expanding focus in the development of proteomics. As mass spectrometry (MS) offers readout of protein conformational changes at both the protein and peptide levels, MS‐based structural proteomics is making significant strides in the
Haiyan Lu, Zexin Zhu, Lauren Fields, Hua Zhang, Lingjun Li   +4 more
wiley   +1 more source

Interplay between de novo and salvage pathways of GDP-fucose synthesis. [PDF]

PLoS One
Skurska E, Olczak M.
europepmc   +1 more source

Recent Advancements in the Treatment of Age‐Related Macular Degeneration

Med Research, EarlyView.
ABSTRACT Age‐related macular degeneration (AMD) is a prevalent cause of visual impairment and blindness among the elderly. AMD can be categorized into two subtypes: “wet” and “dry.” Current treatments for wet AMD mainly involve anti‐vascular endothelial growth factor (VEGF) drugs, and there are three U.S.
Shan Liu, Danyang Lv, Junran Sun, Huixun Jia, Fang Zheng, Felipe Pereira, Siddharth Narendran, Zhenyu Dong, Haiyun Liu, Shunxiang Gao, Peirong Huang   +10 more
wiley   +1 more source

A Focus on Natural Autophagy Modulators as Potential Host‐Directed Weapons Against Emerging and Re‐Emerging Viruses

Medicinal Research Reviews, EarlyView.
ABSTRACT Autophagy is a highly conserved intracellular process involved in maintaining homeostasis and in the degradation of damaged organelles and external pathogens. Nature provides complex and varied reservoirs of scaffolds and chemical entities that may have a pivotal role in the search for new therapeutic leads.
Ilaria Cursaro, Sara Rossi, Stefania Butini, Sandra Gemma, Gabriele Carullo, Giuseppe Campiani   +5 more
wiley   +1 more source

A maize architect: An epiallele of a PfkB-type carbohydrate kinase affects plant growth and development. [PDF]

Plant Cell
Singla-Rastogi M.
europepmc   +1 more source

Shielding Human Adipocytes From Inflammation: The Protective Potential of Polyphenol‐Rich Opuntia ficus‐indica Cladode Extract

Molecular Nutrition &Food Research, EarlyView.
Inflammation of the adipose tissue contributes to metabolic disorders. OFI‐CE regulates the expression of proinflammatory genes in human hypertrophic fat cells. OFI‐CE is a promising candidate for use as a dietary supplement or therapeutic agent in nutritional interventions targeting inflammatory markers associated with obesity.
Stefano Quarta, Nadia Calabriso, Maria Annunziata Carluccio, Clara Albano, Ibrahim Khalifa, Martin Wabitsch, Federica Blando, Marika Massaro   +7 more
wiley   +1 more source

Heterozygous Beta‐Thalassaemia in Pregnancy: Two Rare Causes of Severe Fetal Anemia Requiring Intrauterine Blood Transfusions

Prenatal Diagnosis, EarlyView.
ABSTRACT Aim In this article, we present two cases of severe fetal hemolytic anemia based on a beta‐thalassaemia trait inherited from a single parent. Results These cases, presented at 20 and 28 weeks' gestation, necessitated intra‐uterine blood transfusions.
Eva van der Meij, Frans J. W. Smiers, Tamara T. Koopmann, Ingrid Krapels, Kaatje LePoole, Enrico Lopriore, Johanna M. Middeldorp, Claudia S. Ootjers, Volkher Scharnhorst, Hubertina C. J. Scheepers, Cornelis L. Harteveld, E. J. T. (Joanne) Verweij   +11 more
wiley   +1 more source

Natural Variation of <i>StNADC</i> Regulates Plant Senescence in Tetraploid Potatoes (<i>Solanum tuberosum</i> L.). [PDF]

Int J Mol Sci
Zhang J, Xu J, Bian C, Duan S, Hu J, Qin J, Wu H, He M, Jian Y, Duan Y, Liu J, Wang W, Li G, Jin L.   +13 more
europepmc   +1 more source