Results 211 to 220 of about 14,893 (257)

Opportunities and Challenges of Population Pharmacogenomics

Annals of Human Genetics, EarlyView.
ABSTRACT Pharmacological responses can vary significantly among patients from different ethnogeographic backgrounds. This variability can, at least in part, be attributed to population‐specific genetic patterns in genes involved in drug absorption, distribution, metabolism, and excretion, as well as in genes associated with drug‐induced toxicity ...
Yitian Zhou, Yoomi Park, Mahamadou D. Camara, Volker M. Lauschke   +3 more
wiley   +1 more source

Use of Crithidia fasciculata extract for the facile enzymatic synthesis of GDP-L-[3H]Fucose. [PDF]

Glycobiology
Paredes Franco JC, Güther MLS, Ferguson MAJ.   +2 more
europepmc   +1 more source

Cryptorchidism: Novel genetic insights into CCDC149 mutations

Andrology, EarlyView.
Abstract Background Cryptorchidism, characterized by the failure of one or both testes to descend into the scrotum, is a common congenital condition that can lead to infertility and increased risk of testicular cancer. CCDC149, a coiled‐coil domain‐containing protein, has been implicated in various developmental processes, but its role in the male ...
Shengrong Du, Shan Xu, Lei Yang, Yan Ye, Yuhan Wu, Ziyun Xiao, Xiuqing Dong, Wenliang Yao, Hua Li   +8 more
wiley   +1 more source

Whole Blood Metabolomic Profiling of Mice with Tacrolimus-Induced Chronic Nephrotoxicity: NAD⁺ Depletion with Salvage Pathway Impairment. [PDF]

Antioxidants (Basel)
Nishida S, Ishima T, Iwami D, Nagai R, Aizawa K.   +4 more
europepmc   +1 more source

Real‐world clinical experience with NGS‐based chimerism analyses in haematopoietic stem cell transplant patients

British Journal of Haematology, EarlyView.
This study demonstrates the clinical utility of a next‐generation sequencing (NGS)‐based chimerism assay (CASAL) in haematopoietic stem cell transplantation (HSCT). Compared to conventional short tandem repeat (STR) methods, CASAL showed significantly higher marker informativeness, detecting mixed chimerism (MC) below 5% recipient DNA with a median of ...
Jin Ju Kim, Soon Sung Kwon, Yu Jeong Choi, Yehyun Kang, Yu Jin Park, Saeam Shin, Seung‐Tae Lee, Jong Rak Choi   +7 more
wiley   +1 more source

De novo NAD⁺ synthesis is ineffective for NAD⁺ supply in axenically cultured Caenorhabditis elegans. [PDF]

Commun Biol
Zhu S, Zhang R, Yao L, Lin Z, Li Y, Li S, Wu L.   +6 more
europepmc   +1 more source

Gastrointestinal jumbo phages possess independent synthesis and utilization systems of NAD. [PDF]

Microbiome
Li C, Liu K, Gu C, Li M, Zhou P, Chen L, Sun S, Li X, Wang L, Ni W, Li M, Hu S.   +11 more
europepmc   +1 more source

Advances in Engineering Nucleotide Sugar Metabolism for Natural Product Glycosylation in Saccharomyces cerevisiae. [PDF]

ACS Synth Biol
Crowe SA, Liu Y, Zhao X, Scheller HV, Keasling JD.   +4 more
europepmc   +1 more source

An aneuploidy epistasis map reveals metabolic vulnerabilities associated with supernumerary chromosomes in cancer

Magesh RY, Kaur AN, Keller FN, Frederick A, Tseyang T, Haley JA, Rivera-Nieves AM, Liang AC, Guertin DA, Spinelli JB, Elledge SJ, Watson EV.   +11 more
europepmc   +1 more source

α-Ketoglutarate dehydrogenase is a therapeutic vulnerability in acute myeloid leukemia.

Blood
Millman SE, Chaves-Perez A, Janaki-Raman S, Ho YJ, Morris JP, Narendra V, Chen CC, Jackson BT, Yashinskie JJ, Mezzadra R, Devine TI, Barthet VJA, Saoi M, Baslan T, Tian S, Sachs Z, Finley LWS, Cross JR, Lowe SW.   +18 more
europepmc   +1 more source