Results 221 to 230 of about 17,571 (268)

Glutamine antagonism suppresses tumor growth in adrenocortical carcinoma through inhibition of de novo nucleotide biosynthesis

Chortis V, Borges KS, Yao C, Ribeiro C, Nagano LF, Berber M, Prete A, Najdekr L, Klontzas ME, Jankevics A, Vendramini P, Kremer JL, Kelley L, Raveenthiraraj S, Tsagarakis S, Macech M, Pupovac ID, Papathomas TG, Haykir B, Winder C, Quinkler M, Dennedy MC, Ueland GÅ, Beuschlein F, Tabarin A, Fassnacht M, Taylor AE, Kastelan D, Ambroziak U, Vassiliadi DA, Kiseljak-Vassiliades K, Bancos I, Carlone DL, Dunn WB, Arlt W, Haigis MC, Breault DT.   +36 more
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Plant Nucleotide Sugar Formation, Interconversion, and Salvage by Sugar Recycling*

Annual Review of Plant Biology, 2011
Nucleotide sugars are the universal sugar donors for the formation of polysaccharides, glycoproteins, proteoglycans, glycolipids, and glycosylated secondary metabolites. At least 100 genes encode proteins involved in the formation of nucleotide sugars.
Maor Bar-Peled, Malcolm A O'neill
exaly   +3 more sources

Foscarnet used in salvage therapy of HIV-1 patients harbouring multiple nucleotide excision mutations

AIDS, 2004
We used foscarnet as induction therapy or as maintenance therapy in different dosing regimens in seven severely immunocompromised multidrug-resistant HIV-1 patients. During induction the median decrease in viral load was 1.8 log and increases in CD4 cell counts ranging from zero to 136 cells/mm 3 were observed during maintenance therapy, suggesting ...
Sofie Mathiesen, Birgit Thorup Røge, Nina Weis, Jens Lundgren, Niels Obel, Jan Gerstoft   +5 more
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Purine salvage pathways for the biosynthesis in vitro of adenine nucleotides in the guinea pig vas deferens

Biochemical Pharmacology, 1978
Abstract The guinea pig vas deferens has been found to possess at least two active anabolic pathways for adenine nucleotide biosynthesis. Our studies in vitro show that [ 3 H]adenosine and [ 3 H]adenine may be important precursors in purine salvage. Both precursors are eventually converted to [ 3 H]AMP prior to final incorporation into [ 3 H]ATP. [
James N. Rowe, Knox Van Dyke, Robert E. Stitzel   +2 more
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In vitro 5-phosphoribosyl 1-pyrophosphate-independent salvage biosynthesis of ribo- and deoxyriboadenine nucleotides in Bacillus cereus

Biochimica et Biophysica Acta (BBA) - General Subjects, 1985
The pools of free ribose 1-phosphate and deoxyribose 1-phosphate have been measured in Bacillus cereus. It is shown that crude extracts of the same organism can actively utilize the sugar phosphates to convert adenine to ATP and deoxyATP, via a 'salvage' pathway, involving adenine ribosylation (or deoxyribosylation), followed by multiple ...
Pier Luigi Ipata, Stefania Gini, Maria Grazia Tozzi   +2 more
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Enzymic capacities of purine de Novo and salvage pathways for nucleotide synthesis in normal and neoplastic tissues.

Cancer research, 1984
The enzymic capacities of the de novo and the salvage pathways for purine nucleotide synthesis were compared in rat in normal, differentiating, and regenerating liver, and in three hepatomas of widely different growth rates. The activities of the key de novo and salvage enzymes were also determined in mouse lung and Lewis lung carcinoma, in human ...
Yutaka Natsumeda, Noémi Prajda, John P. Donohue, John L. Glover, George Weber   +4 more
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Adenine nucleotide salvage synthesis in the rat heart; pathways of adenosine salvage

Biochimica et Biophysica Acta (BBA) - Nucleic Acids and Protein Synthesis, 1972
Abstract The activities of the enzymes involved in the salvage synthesis of AMP from adenosine, and the activities of adenine phosphoribosyltransferase and xanthine oxidase have been measured in rat heart extracts. The enzyme activities found show that in the rat heart the conversion of adenosine to AMP can take place by direct phosphorylation and ...
M H, Maguire, M C, Lukas, J F, Rettie
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Salvage synthesis of purine nucleotides by Helicobacter pylori

Journal of Applied Bacteriology, 1994
G.L. MENDZ, B.M. JIMENEZ, S.L. HAZELL, A.M. GERO AND W.J. O'SULLIVAN. 1994. The incorporation of purine nucleotide precursors into Helicobacter pylori and the activities of enzymes involved in nucleotide salvage biosynthetic pathways were investigated by radioactive tracer analysis and ...
G L, Mendz, B M, Jimenez, S L, Hazell, A M, Gero, W J, O'Sullivan   +4 more
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Macrophages say NO to nucleotide synthesis and salvage instead

Nature Metabolism
Eloïse Marques, Dylan G. Ryan
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Purine salvage to adenine nucleotides in different skeletal muscle fiber types

Journal of Applied Physiology, 2001
Rates of purine salvage of adenine and hypoxanthine into the adenine nucleotide (AdN) pool of the different skeletal muscle phenotype sections of the rat were measured using an isolated perfused hindlimb preparation. Tissue adenine and hypoxanthine concentrations and specific activities were controlled over a broad range of purine concentrations ...
J J, Brault, R L, Terjung
openaire   +2 more sources