Results 21 to 30 of about 30,194 (292)
Synthesis, Salvage, and Catabolism of Uridine Nucleotides in Boron-Deficient Squash Roots [PDF]
Plant Physiology, 1981 Previous work has provided evidence that plants may require boron to maintain adequate levels of pyrimidine nucleotides, suggesting that the state of boron deficiency may actually be one of pyrimidine starvation. Since the availability of pyrimidine nucleotides is influenced by their rates of synthesis, salvage, and catabolism, we compared these ...
Carol J. Lovatt +2 more
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LOW ADENINE NUCLEOTIDE POOLS IN BLOOM'S SYNDROME MAY REFLECT A DEFECTIVE SALVAGE PURINE BIOSYNTHESIS: 126 [PDF]
Pediatric Research, 1985 A nucleotide analysis of Bloom's syndrome lymphocytes and fibroblasts has revealed a partial depletion in adenine nucleotide pools. ATP/ADP ratio in these cells was at least three-fold lower than in primary cultures of normal human cells. Fractionation of each adenine nucleotide by high performance liquid chromatography showed that differences did not ...
Héctor Martínez-Valdez +3 more
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PLOS Pathogens, 2016 The human pathogenic parasite Trypanosoma brucei possess both de novo and salvage routes for the biosynthesis of pyrimidine nucleotides. Consequently, they do not require salvageable pyrimidines for growth. Thymidine kinase (TK) catalyzes the formation of dTMP and dUMP and is one of several salvage enzymes that appear redundant to the de novo pathway ...
Christopher Leija +7 more
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A model for compartmentation of de novo and salvage thymidine nucleotide pools in mammalian cells. [PDF]
Proceedings of the National Academy of Sciences, 1975 When [3H]thymidine is added to HeLa cells grown in thymidine-free medium it is incorporated into DNA almost immediately at full specific activity, blocking any further incorporation of de novo synthesized thymidine nucleotides. Apparently, de novo nucleotide pools [Baumunk, C.N. & Friedman, D.L. (1971) Cancer Res.
Daniel Kuebbing, Rudolf Werner
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Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 1995 Salvage and de novo purine and pyrimidine nucleotide syntheses were studied in H9 (a human lymphoid cell line) and H9-AZT cells (chronically zidovudine-exposed H9 cells). H9-AZT cells incorporated 18% and 27% more hypoxanthine and uridine, respectively, than H9 cells.
Ram P. Agarwal +3 more
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AIDS, 2004 We used foscarnet as induction therapy or as maintenance therapy in different dosing regimens in seven severely immunocompromised multidrug-resistant HIV-1 patients. During induction the median decrease in viral load was 1.8 log and increases in CD4 cell counts ranging from zero to 136 cells/mm 3 were observed during maintenance therapy, suggesting ...
Sofie Mathiesen +5 more
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Biomedicines, 2022 Chronic hypoxia drives vascular dysfunction by various mechanisms, including changes in mitochondrial respiration. Although endothelial cells (ECs) rely predominantly on glycolysis, hypoxia is known to alter oxidative phosphorylation, promote oxidative ...
Barbara Kutryb-Zajac +6 more
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Animals, 2022 Skeletal muscle growth has always been the focus of the broiler industry, and circRNAs play a significant role in this process. We collected leg muscles of slow- and fast-growing Bian chicken embryos in the study at 14 (S14 and F14) and 20 (S20 and F20 ...
Genxi Zhang +12 more
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Frontiers in Cellular and Infection Microbiology, 2023 Maintenance of dNTPs pools in Trypanosoma brucei is dependent on both biosynthetic and degradation pathways that together ensure correct cellular homeostasis throughout the cell cycle which is essential for the preservation of genomic stability. Both the
Pablo Antequera-Parrilla +4 more
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Re-Discovery of Pyrimidine Salvage as Target in Cancer Therapy
Cells, 2022 Nucleotides are synthesized through two distinct pathways: de novo synthesis and nucleoside salvage. Whereas the de novo pathway synthesizes nucleotides from amino acids and glucose, the salvage pathway recovers nucleosides or bases formed during DNA or ...
Melanie Walter, Patrick Herr
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