Results 21 to 30 of about 17,571 (268)

Pyrimidine Salvage Enzymes Are Essential for De Novo Biosynthesis of Deoxypyrimidine Nucleotides in Trypanosoma brucei

PLOS Pathogens, 2016
The human pathogenic parasite Trypanosoma brucei possess both de novo and salvage routes for the biosynthesis of pyrimidine nucleotides. Consequently, they do not require salvageable pyrimidines for growth. Thymidine kinase (TK) catalyzes the formation of dTMP and dUMP and is one of several salvage enzymes that appear redundant to the de novo pathway ...
Christopher Leija, Filipa Rijo‐Ferreira, Lisa N. Kinch, Nick V. Grishin, Nicole Nischan, Jennifer J. Kohler, Zeping Hu, Margaret A. Phillips   +7 more
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Salvage enzymes in nucleotide biosynthesis [PDF]

, 2007
Balanced pools of deoxyribonucleoside triphosphates (dNTPs), the building blocks of DNA, and ribonucleoside triphosphates (NTPs), the precursors of RNA, are crucial for a controlled cell proliferation. The dNTPs and NTPs are synthesized de novo via energy-consuming reactions involving low-weight molecules, and through a salvage pathway by recycling ...
U. Kosinska
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Structural studies of salvage enzymes in nucleotide biosynthesis [PDF]

, 2007
There are two routes to produce deoxyribonucleoside triphosphates (dNTPs) precursors for DNA synthesis, the de novo and the salvage pathways. Deoxyribonucleoside kinases (dNKs) perform the initial phosphorylation of deoxyribonucleosides (dNs). Furthermore, they can act as activators for several medically important nucleoside analogs (NAs) for treatment
M. Welin
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Co-culture metabolomics: a powerful tool for uncovering host-pathogen phenotypes driving Burkholderia infections [PDF]

mSystems
Melioidosis, caused by the soil-dwelling pathogen Burkholderia pseudomallei (Bt), is a severe respiratory infection with limited treatment options. To investigate the host-pathogen metabolic interplay occurring during these intracellular infections ...
Stephanie L. Bishop
doaj   +2 more sources

Three Arabidopsis UMP kinases have different roles in pyrimidine nucleotide biosynthesis and (deoxy)CMP salvage [PDF]

The Plant Cell
Abstract Pyrimidine nucleotide monophosphate biosynthesis ends in the cytosol with uridine monophosphate (UMP). UMP phosphorylation to uridine diphosphate (UDP) by UMP KINASEs (UMKs) is required for the generation of all pyrimidine (deoxy)nucleoside triphosphates as building blocks for nucleic acids and central metabolites like UDP ...
Jannis Rinne, Markus Niehaus, Nieves Medina‐Escobar, Henryk Straube, Frank Schaarschmidt, Nils Rugen, Hans‐Peter Braun, Marco Herde, Claus‐Peter Witte   +8 more
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A model for compartmentation of de novo and salvage thymidine nucleotide pools in mammalian cells. [PDF]

Proceedings of the National Academy of Sciences, 1975
When [3H]thymidine is added to HeLa cells grown in thymidine-free medium it is incorporated into DNA almost immediately at full specific activity, blocking any further incorporation of de novo synthesized thymidine nucleotides. Apparently, de novo nucleotide pools [Baumunk, C.N. & Friedman, D.L. (1971) Cancer Res.
Daniel Kuebbing, Rudolf Werner
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Guanosine primes acute myeloid leukemia for differentiation via guanine nucleotide salvage synthesis. [PDF]

Am J Cancer Res, 2022
Wang H, He X, Li Z, Jin H, Wang X, Li L.
europepmc   +2 more sources

Impact of equilibrative nucleoside transporters on Toxoplasma gondii infection and differentiation [PDF]

mBio
Toxoplasma gondii cannot synthesize purines de novo and must import them; however, the functional interplay among its four equilibrative nucleoside transporters (ENTs) homologs remains unclear.
Gabriel Messina, Amber Goerner, Charlotte Bennett, Euwen Brennan, Vern B. Carruthers, Bruno Martorelli Di Genova   +5 more
doaj   +2 more sources

Effect of long-term zidovudine exposure on salvage and de novo purine and pyrimidine nucleotide syntheses

Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 1995
Salvage and de novo purine and pyrimidine nucleotide syntheses were studied in H9 (a human lymphoid cell line) and H9-AZT cells (chronically zidovudine-exposed H9 cells). H9-AZT cells incorporated 18% and 27% more hypoxanthine and uridine, respectively, than H9 cells.
Ram P. Agarwal, Jun He, Meena B. Bansal, Vishal Gupta   +3 more
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Toxoplasma gondii: Are Host Cell Adenosine Nucleotides a Direct Source for Purine Salvage?

Experimental Parasitology, 2000
Abstract Ngo, H. M., Ngo, E. O., Bzik, D. J., and Joiner, K. A. 2000. Toxoplasma gondii: Are host cell adenosine nucleotides a direct source for purine salvage? Experimental Parasitology95, 148–153.
Huân M. Ngô, Emily O. Ngo, David J. Bzik, Keith A. Joiner   +3 more
openalex   +3 more sources