Results 21 to 30 of about 33,140 (287)
Frontiers in Cellular and Infection Microbiology, 2023 Maintenance of dNTPs pools in Trypanosoma brucei is dependent on both biosynthetic and degradation pathways that together ensure correct cellular homeostasis throughout the cell cycle which is essential for the preservation of genomic stability. Both the
Pablo Antequera-Parrilla +4 more
doaj +1 more source
Re-Discovery of Pyrimidine Salvage as Target in Cancer Therapy
Cells, 2022 Nucleotides are synthesized through two distinct pathways: de novo synthesis and nucleoside salvage. Whereas the de novo pathway synthesizes nucleotides from amino acids and glucose, the salvage pathway recovers nucleosides or bases formed during DNA or ...
Melanie Walter, Patrick Herr
doaj +1 more source
Chronological lifespan extension and nucleotide salvage inhibition in yeast by isonicotinamide supplementation [PDF]
, 2021 AbstractIsonicotinamide (INAM) is an isomer of the NAD+precursor nicotinamide (NAM) that stimulates the enzymatic activity of Sir2, an NAD+-dependent histone deacetylase from the budding yeast,Saccharomyces cerevisiae. Supplementing INAM into growth media promotes the replicative lifespan (RLS) of this single cell organism by maintaining intracellular ...
Agata I. Kalita +9 more
openaire +1 more source
ATR inhibition facilitates targeting of leukemia dependence on convergent nucleotide biosynthetic pathways. [PDF]
, 2017 Leukemia cells rely on two nucleotide biosynthetic pathways, de novo and salvage, to produce dNTPs for DNA replication. Here, using metabolomic, proteomic, and phosphoproteomic approaches, we show that inhibition of the replication stress sensing kinase ...
Abt, Evan R +20 more
core +2 more sources
Nature Communications, 2023 Cancer cells utilize the main de novo pathway and the alternative salvage pathway for deoxyribonucleotide biosynthesis to achieve adequate nucleotide pools.
Magali Saez-Ayala +21 more
doaj +1 more source
Synthesis, Salvage, and Catabolism of Uridine Nucleotides in Boron-Deficient Squash Roots [PDF]
Plant Physiology, 1981 Previous work has provided evidence that plants may require boron to maintain adequate levels of pyrimidine nucleotides, suggesting that the state of boron deficiency may actually be one of pyrimidine starvation. Since the availability of pyrimidine nucleotides is influenced by their rates of synthesis, salvage, and catabolism, we compared these ...
Lovatt, Carol J. +2 more
openaire +3 more sources
Scientific Reports, 2021 All medically important unicellular protozoans cannot synthesize purines de novo and they entirely rely on the purine salvage pathway (PSP) for their nucleotide generation.
Eva Doleželová +6 more
doaj +1 more source
Nucleoside Metabolism Is Induced in Common Bean During Early Seedling Development
Frontiers in Plant Science, 2021 Nucleoside hydrolases (NSH; nucleosidases) catalyze the cleavage of nucleosides into ribose and free nucleobases. These enzymes have been postulated as key elements controlling the ratio between nucleotide salvage and degradation.
Elena Delgado-García +5 more
doaj +1 more source
Trypanosoma brucei methylthioadenosine phosphorylase protects the parasite from the antitrypanosomal effect of deoxyadenosine [PDF]
, 2016 Trypanosoma brucei causes African sleeping sickness for which no vaccine exists and available treatments are of limited use due to their high toxicity or lack of efficacy. T.
de Koning, Harry P. +4 more
core +1 more source
Nucleoside salvage pathway kinases regulate hematopoiesis by linking nucleotide metabolism with replication stress [PDF]
Journal of Experimental Medicine, 2012 Nucleotide deficiency causes replication stress (RS) and DNA damage in dividing cells. How nucleotide metabolism is regulated in vivo to prevent these deleterious effects remains unknown. In this study, we investigate a functional link between nucleotide deficiency, RS, and the nucleoside salvage pathway (NSP) enzymes deoxycytidine kinase (dCK) and ...
Austin, Wayne R +10 more
openaire +4 more sources