Results 41 to 50 of about 17,571 (268)

Rhythmic Nucleotide Synthesis in the Liver: Temporal Segregation of Metabolites

Cell Reports, 2012
The synthesis of nucleotides in the body is centrally controlled by the liver, via salvage or de novo synthesis. We reveal a pervasive circadian influence on hepatic nucleotide metabolism, from rhythmic gene expression of rate-limiting enzymes to ...
Jean-Michel Fustin, Masao Doi, Hiroyuki Yamada, Rie Komatsu, Shigeki Shimba, Hitoshi Okamura   +5 more
doaj   +1 more source

Structural phylogenomics reveals gradual evolutionary replacement of abiotic chemistries by protein enzymes in purine metabolism. [PDF]

PLoS ONE, 2013
The origin of metabolism has been linked to abiotic chemistries that existed in our planet at the beginning of life. While plausible chemical pathways have been proposed, including the synthesis of nucleobases, ribose and ribonucleotides, the cooption of
Kelsey Caetano-Anollés, Gustavo Caetano-Anollés   +1 more
doaj   +1 more source

Interrelationship between Salvage Pathway and Synthesisde novoof Adenine Nucleotides in Kidney Slices

Hoppe-Seyler´s Zeitschrift für physiologische Chemie, 1969
Péter Markó, E. Gerlach, Heinz‐Gerd Zimmer, I Pechán, Thomas Cremer, Christian Trendelenburg   +5 more
openalex   +4 more sources

Nucleobase and nucleoside transport and integration into plant metabolism

Frontiers in Plant Science, 2014
Nucleotide metabolism is an essential process in all living organisms. Besides newly synthesized nucleotides, the recycling (salvage) of partially degraded nucleotides i.e.
Christopher eGirke, Manuel eDaumann, Sandra eNiopek-Witz, Torsten eMöhlmann   +3 more
doaj   +1 more source

Substrate-Based Design of Cytosolic Nucleotidase IIIB Inhibitors and Structural Insights into Inhibition Mechanism

Pharmaceuticals, 2022
Cytosolic nucleotidases (cNs) catalyze dephosphorylation of nucleoside 5’-monophosphates and thereby contribute to the regulation of nucleotide levels in cells.
Dorota Kubacka, Mateusz Kozarski, Marek R. Baranowski, Radoslaw Wojcik, Joanna Panecka-Hofman, Dominika Strzelecka, Jerome Basquin, Jacek Jemielity, Joanna Kowalska   +8 more
doaj   +1 more source

Down-Regulation of Phosphoribosyl Pyrophosphate Synthetase 1 Inhibits Neuroblastoma Cell Proliferation

Cells, 2019
Phosphoribosyl pyrophosphate synthetase 1 (PRPS1) is a key enzyme in de novo nucleotide synthesis and nucleotide salvage synthesis pathways that are critical for purine and pyrimidine biosynthesis.
Jifu Li, Junhong Ye, Shunqin Zhu, Hongjuan Cui   +3 more
doaj   +1 more source

Antitumor Mechanism of Hydroxycamptothecin via the Metabolic Perturbation of Ribonucleotide and Deoxyribonucleotide in Human Colorectal Carcinoma Cells

Molecules, 2021
Hydroxycamptothecin (SN38) is a natural plant extract isolated from Camptotheca acuminate. It has a broad spectrum of anticancer activity through inhibition of DNA topoisomerase I, which could affect DNA synthesis and lead to DNA damage. Thus, the action
Yan Li, Wendi Luo, Huixia Zhang, Caiyun Wang, Caiyuan Yu, Zhihong Jiang, Wei Zhang   +6 more
doaj   +1 more source

Importance Of Pyrimidine Nucleotide Salvage Pathways For Dna Synthesis In Skin

Journal of Investigative Dermatology, 1976
Split-thickness rabbit skins were minced and incubated in vitro with radioactive precursors selected to measure do novo and salvage pathways for pyrimidine nucleotide synthesis. In this system, both the salvage precursors [3H]thymidine and [14C]cytidine were incorporated actively into skin DNA and only [14C]cytidine into skin RNA.
DeLapp, Neil W., Karasek, Marvin A.
openaire   +2 more sources

Adenosine Triphosphate and Adenylate Energy Charge in Ready-to-Eat Food

Metabolites
It is commonly accepted that dietary nucleotides should be considered as essential nutrients originating mainly but not exclusively from meat and fish dishes.
Georgii Konoplev, Alar Sünter, Artur I. Kuznetsov, Piret Raudsepp, Tõnu Püssa, Lauri Toom, Linda Rusalepp, Dea Anton, Oksana V. Stepanova, Daniil Lyalin, Liubov Abramova, Andrey Kozin, Oksana S. Stepanova, Aleksandr Frorip, Mati Roasto   +14 more
doaj   +1 more source

Combining multi‐omics analysis to identify host‐targeted targets for the control of Brucella infection

Microbial Biotechnology, 2023
Human infections caused by Brucella (called brucellosis) are among the most common zoonoses worldwide with an estimated 500,000 cases each year. Since chronic Brucella infections are extremely difficult to treat, there is an urgent need for more ...
Jiuwang Yu, Hongwei Yuan, Jiarong Guo, Zhiheng Dong, Sha Li, Quan Fu, Bilige Aode, Sachula Baoyin, Lidao Bao, Lan Wu   +9 more
doaj   +1 more source