Results 81 to 90 of about 30,194 (292)

Uneven distribution of cobamide biosynthesis and dependence in bacteria predicted by comparative genomics. [PDF]

, 2019
The vitamin B12 family of cofactors known as cobamides are essential for a variety of microbial metabolisms. We used comparative genomics of 11,000 bacterial species to analyze the extent and distribution of cobamide production and use across bacteria ...
Haft, David R, Han, Andrew W, Jackson, Samantha N, Mok, Kenny C, Seth, Erica C, Shelton, Amanda N, Taga, Michiko E   +6 more
core   +1 more source

Network reconstruction of platelet metabolism identifies metabolic signature for aspirin resistance. [PDF]

, 2014
Recently there has not been a systematic, objective assessment of the metabolic capabilities of the human platelet. A manually curated, functionally tested, and validated biochemical reaction network of platelet metabolism, iAT-PLT-636, was reconstructed
Bordbar, Aarash, Jamshidi, Neema, Palsson, Bernhard Ø, Rahmanian, Sorena, Thomas, Alex   +4 more
core   +2 more sources

Therapeutic Implants: Mechanobiologic Enhancement of Osteogenic, Angiogenic, and Myogenic Responses in Human Mesenchymal Stem Cells on 3D‐Printed Titanium Truss

Advanced Healthcare Materials, EarlyView.
This study investigates a synergistic effect between 3D‐printed surface features and mechanical micro‐strain in enhancing the osteogenic, angiogenic, and myogenic responses of human mesenchymal stem cells (hMSCs). Load‐induced mechanotransduction, facilitated by the implant's architectural design, significantly amplifies hMSC differentiation.
Se‐Hwan Lee, Ali Kiapour, Brendan D. Stoeckl, Ellen Y. Zhang, Matthew R. Begley, Jarod Oldham, Lewis Harrison, Jessee Hunt, Robert L. Mauck, Su Chin Heo   +9 more
wiley   +1 more source

DNA‑Directed Assembly of Photonic Nanomaterials for Diagnostic and Therapeutic Applications

Advanced Materials, EarlyView.
DNA‐directed assembly offers a powerful strategy for constructing structured photonic nanomaterials with precise spatial control. This review provides a comprehensive overview of recent advancements in DNA‐assembled photonic nanomaterials for diagnostics and therapeutics, highlighting key design principles, functionalization strategies, and optical ...
Longjiang Ding, Bing Liu, Andreas Peil, Sisi Fan, Jie Chao, Na Liu   +5 more
wiley   +1 more source

Phosphoglucomutase Is Not the Target for Galactose Toxicity in Plants

Frontiers in Plant Science, 2020
Plants synthesize a number of different oligomeric or polymeric sugars containing galactose. During growth and development some of these carbohydrates are metabolized or remodeled releasing galactose as a breakdown product.
Martina Althammer, Constantin Blöchl, Roland Reischl, Christian G. Huber, Raimund Tenhaken   +4 more
doaj   +1 more source

Oxaliplatin for the treatment of cisplatin-resistant cancer: a systematic review [PDF]

, 2007
Oxaliplatin is widely regarded as being active in cisplatin-resistant cancer. We undertook a systematic review of the literature to identify, describe and critique the clinical and pre-clinical evidence for the use of oxaliplatin in patients with ...
Bokemeyer, Britta Stordal, Chaney, Chaney, Chollet, Culy, De Giorgi, Delaloge, Dieras, Dunn, El-akawi, Ezcurdia, Faivre, Faivre, Fizazi, Fracasso, Fracasso, Fukuda, Gibbons, Gore, Gourdier, Grothey, Grothey, Hector, Ibrahim, Kawai, Kim, Kishi, Kollmannsberger, Kollmannsberger, Kollmannsberger, Kuroda, Kweekel, Lanzi, Lebwohl, Li, Liu, Mani, Markman, Martelli, Motzer, Mukai, Nick Pavlakis, Nicoletto, Pectasides, Pectasides, Pectasides, Piccart, Raspagliesi, Raymond, Rixe, Ross Davey, Savaraj, Scartozzi, Sharp, Sockalingam, Soulie, Soulie, Stordal, Sundar, Tashiro, Valerio, Varma, Viens, Winquist, Yamamoto   +65 more
core   +2 more sources

Mussel‐Inspired Molecular Strategies for Fabricating Functional Materials With Underwater Adhesion and Self‐Healing Properties

Advanced Materials, EarlyView.
This review systematically examines the nanomechanical mechanisms of mussel‐inspired molecular interactions, primarily investigated by direct force measurement techniques such as surface forces apparatus and atomic force microscopy. The macroscopic adhesive and self‐healing performances of mussel‐inspired functional materials, including coacervates ...
Pan Huang, Hongjian Zhang, Hongbo Zeng
wiley   +1 more source

Plasmids in the aphid endosymbiont Buchnera aphidicola with the smallest genomes. A puzzling evolutionary story.

, 2006
Buchnera aphidicola, the primary endosymbiont of aphids, has undergone important genomic and biochemical changes as an adaptation to intracellular life.
Gil, Rosario, Latorre, Amparo, Perez-Brocal, Vicente, Sabater-Muñoz, Beatriz, Silva, Francisco J   +4 more
core   +1 more source

Characterization of Cell Glycocalyx with Mass Spectrometry Methods. [PDF]

, 2019
The cell membrane plays an important role in protecting the cell from its extracellular environment. As such, extensive work has been devoted to studying its structure and function.
Lebrilla, Carlito B, Li, Qiongyu, Wong, Maurice, Xie, Yixuan   +3 more
core   +2 more sources

Contribution of de‐novo and salvage synthesis to the uracil nucleotide pool in mouse tissues and tumors in vivo [PDF]

European Journal of Biochemistry, 1992
The relative contribution of de‐novo and salvage synthesis to tissue pyrimidine nucleotide pools is an important parameter in the rational design of anti‐pyrimidine therapies, but has not been measured in vivo. We have measured the contribution of de‐novo synthesis to the total acid‐soluble uracil nucleotide pool in mouse tissues by analysis of the ...
Daniel W. Zaharevitz, John M. Strong, Roosevelt Hyman, Lawrence W. Anderson, Nancy Malinowski, Richard L. Cysyk   +5 more
openaire   +3 more sources