Results 101 to 110 of about 551,715 (314)
Nucleotides: Structure and Properties
, 2005 Nucleotides consist of a nitrogen-containing base, a five-carbon sugar, and one or more phosphate groups. Cells contain many types of nucleotides, which play a central role in a wide variety of cellular processes, including metabolic regulation and the ...
Richard Peter Bowater, Bowater, RP
core +1 more source
Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola +11 more
wiley +1 more source
Disruption of nucleotide biosynthesis reprograms mitochondrial metabolism to inhibit adipogenesis
Journal of Lipid ResearchA key organismal response to overnutrition involves the development of new adipocytes through the process of adipogenesis. Preadipocytes sense changes in the systemic nutrient status and metabolites can directly modulate adipogenesis.
Julia A. Pinette +16 more
doaj +1 more source
, 2013 Analysis of the nucleotides and stress-relevant markers cAMP and ppGpp (mean values including the standard deviation of the mean) during the batch cultivations. Nucleotides were analyzed by HPLC according to [15].
Peter M. Krempl (443199) +7 more
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Promiscuous stimulation of HSP70 ATPase activity by parasite‐derived J‐domains
FEBS Open Bio, EarlyView.The malaria parasite Plasmodium falciparum exports three highly homologous yet functionally divergent J‐domain proteins into human erythrocytes. Here, we show that J‐domains isolated from all three proteins effectively stimulate the ATPase activity of both endogenous host and exported parasite HSP70 chaperones.
Julian Barth +6 more
wiley +1 more source
Разработка и регистрация лекарственных средств, 2019 The article presents information on the structure, classification and functions of NO-synthases. The main inhibitors of the enzyme, as well as their mechanisms of action, are considered. Among the substances activating the activity of the enzyme, special
E. S. Kokareva +6 more
doaj
Molecular analysis of mammalian adenylyl cyclases and bacterial adenylyl cyclase toxins
, 2009 The cAMP signaling pathway is crucial for many physiological processes and many disease states like neurodegenerative diseases, mood disorders, pain, drug dependency or heart failure.
Göttle, Martin
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Sublingual nucleotides and immune response to exercise [PDF]
, 2012 Evidence exists regarding the potential role of exogenous nucleotides as regulators of the immune function in physically active humans, yet the potential use of nucleotides has been hindered by their low bioavailability after oral administration.
Sergej M Ostojic +3 more
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FEBS Open Bio, EarlyView.This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel +4 more
wiley +1 more source