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Polyamine/Nucleotide Coacervates Provide Strong Compartmentalization of Mg²⁺, Nucleotides, and RNA.

Langmuir, 2016
Phase separation of aqueous solutions containing polyelectrolytes can lead to formation of dense, solute-rich liquid droplets referred to as coacervates, surrounded by a dilute continuous phase of much larger volume.
Erica A. Frankel   +2 more
semanticscholar   +1 more source

Nucleotide rigidity

Nature, 1976
It is show that in aqueous solution the backbone conformation of adenosine is as much flexible as that of 3'-AMP, 5'-AMP and 3', 5'-ADP indicating that nucleotides are not any more rigid than nucleosides. The flexible conformation of the monomeric components is conserved in the nucleotidyl units of destacked ApA, ApApA and poly(A), but it is not ...
F E, Evans, R H, Sarma
openaire   +2 more sources

Signal transduction via P2-purinergic receptors for extracellular ATP and other nucleotides.

American Journal of Physiology, 1993
Extracellular ATP, at micromolar concentrations, induces significant functional changes in a wide variety of cells and tissues. ATP can be released from the cytosol of damaged cells or from exocytotic vesicles and/or granules contained in many types of ...
G. Dubyak, Chakib El-Moatassim
semanticscholar   +1 more source

Enzymes involved in metabolism of extracellular nucleotides and nucleosides: Functional implications and measurement of activities

Critical reviews in biochemistry and molecular biology, 2014
Extracellular nucleotides and nucleosides mediate diverse signaling effects in virtually all organs and tissues. Most models of purinergic signaling depend on functional interactions between distinct processes, including (i) the release of endogenous ATP
G. Yegutkin
semanticscholar   +1 more source

Cyclic nucleotides

Phytochemistry, 2004
The natural occurrence of cyclic nucleotides in higher plants, formerly a topic of fierce debate, is now established, as is the presence of nucleotidyl cyclases and cyclic nucleotide phosphodiesterases capable of their synthesis and breakdown. Here we describe the significant properties of cyclic nucleotides, also outlining their second messenger ...
Russell P, Newton, Christopher J, Smith
openaire   +2 more sources

Mass spectrometry analysis of nucleosides and nucleotides.

Mass spectrometry reviews (Print), 2014
Mass spectrometry has been widely utilised in the study of nucleobases, nucleosides and nucleotides as components of nucleic acids and as bioactive metabolites in their own right.
E. Dudley, L. Bond
semanticscholar   +1 more source

Nucleotide Metabolism

2011
Publisher Summary This chapter discusses the synthesis and degradation of nucleotides. A nucleotide consists of a purine or pyrimidine base, a pentose, and a phosphate. Nucleotides are synthesized by two types of metabolic pathways: de novo synthesis and salvage pathways.
Chung-Eun Ha, N.V. Bhagavan
openaire   +3 more sources

The Biosynthesis of Nucleotides

2004
The synthesis of PRPP from ATP and ribose-5-phosphate is catalyzed by phosphoribosylpyrophosphate synthetase as follows:
openaire   +2 more sources

The metabolism of nucleotides

1986
A supply of ribonucleoside and deoxyribonucleoside 5′-triphosphates is required for the biosynthesis of nucleic acids (chapters 6 and 8). The synthesis of these compounds occurs in two main stages: (1) the formation of the purine and pyrimidine ring systems and their conversion into the parent ribonucleoside monophosphate, inosine 5′-monophosphate (IMP)
Roger L. P. Adams   +2 more
openaire   +2 more sources

Conversion of neuronal growth cone responses from repulsion to attraction by cyclic nucleotides.

Science, 1998
Nerve growth is regulated by attractive and repulsive factors in the nervous system. Microscopic gradients of Collapsin-1/Semaphorin III/D (Sema III) and myelin-associated glycoprotein trigger repulsive turning responses by growth cones of cultured ...
Hongjun Song   +6 more
semanticscholar   +1 more source

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