Results 71 to 80 of about 571,177 (299)
Marine Drugs, 2018 Over the past seven decades, particularly since the discovery of the first marine-derived nucleosides, spongothymidine and spongouridine, from the Caribbean sponge Cryptotethya crypta in the early 1950s, marine natural products have emerged as unique ...
Amr El-Demerdash +5 more
doaj +1 more source
A nucleotide‐independent, pan‐RAS‐targeted DARPin elicits anti‐tumor activity in a multimodal manner
Molecular Oncology, EarlyView.We report a Designed Ankyrin Repeat Protein that binds and inhibits RAS proteins, which serve as central cell signaling hubs and are essential for the progression of many cancers. Its unique feature is that it does not discriminate between different RAS isoforms or mutations and is capable of binding to RAS in both its active (GTP‐bound) and inactive ...
Jonas N. Kapp +13 more
wiley +1 more source
BiomedicinesAdenine nucleotides play a critical role in maintaining essential functions of red blood cells (RBCs), including energy metabolism, redox status, shape fluctuations and RBC-dependent endothelial and microvascular functions.
Marzena Romanowska-Kocejko +9 more
doaj +1 more source
ROLE OF PURINERGIC RECEPTORS IN IMMUNE RESPONSE
Журнал микробиологии, эпидемиологии и иммунобиологии, 2016 Purine receptors are located on immune and somatic cells of animal and human organisms. Summation of signals from purine and TOLL-like receptors takes place on the level of inflammasome formation and results in summation of the first and second signals ...
I. B. Semenova
doaj +1 more source
Quantum Requirement for Phosphopyridine Nucleotide Reduction in Photosynthesis. [PDF]
, 1959 L.N.M. Duysens, J. Amesz
openalex +1 more source
BioTechnologia, 2015 The object of the invention are 1) nucleotide analogues, 2) antiviral pro-nucleotides, 3) a use of nucleotide analogues and pharmaceutical composition, 4) a phosphorylating agent for synthesis of nucleotide analogue, and 5) a method of synthesis of nucleotide analogues.
Agnieszka Szymanska-Michalak +7 more
openaire +2 more sources
Unraveling LINE‐1 retrotransposition in head and neck squamous cell carcinoma
Molecular Oncology, EarlyView.The novel RetroTest method allows the detection of L1 activation in clinical samples with low DNA input, providing global L1 activity and the identification of the L1 source element. We applied RetroTest to a real‐world cohort of HNSCC patients where we reported an early L1 activation, with more than 60% of T1 patients showing L1 activity.
Jenifer Brea‐Iglesias +12 more
wiley +1 more source
Molecular Oncology, EarlyView.Analysis of treatment‐naïve high‐grade serous ovarian carcinoma (HGSOC) and control tissues for ERVs, LINE‐1 (L1), inflammation, and immune checkpoints identified five clusters with diverse patient recurrence‐free survivals. An inflammation score was calculated and correlated with retroelement expression, where one novel cluster (Triple‐I) with high ...
Laura Glossner +6 more
wiley +1 more source
Nucleotide exchange reactions catalysed by ribonuclease and spleen phosphodiesterase. 1. Synthesis and interconversion of simple esters of ribomononucleotides [PDF]
, 1955 L. A. Heppel, Paul R. Whitfeld
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Molecular Oncology, EarlyView.Human cytomegalovirus infection is common in normal prostate epithelium, prostate tumor tissue, and prostate cancer cell lines. CMV promotes cell survival, proliferation, and androgen receptor signaling. Anti‐CMV pharmaceutical compounds in clinical use inhibited cell expansion in prostate cancer models in vitro and in vivo, motivating investigation ...
Johanna Classon +13 more
wiley +1 more source