Results 51 to 60 of about 584,446 (261)

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

open access: yesFEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

open access: yesFEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge   +6 more
wiley   +1 more source

Thermal Diffusion of Nucleotides

open access: yes, 2012
We investigate the thermal diffusion behavior of aqueous solutions of nucleotides using an infrared thermal diffusion forced Rayleigh scattering (IR-TDFRS) setup.
Kriegs, H., Wiegand, S., Wang, Z.
core   +1 more source

Dietary Supplementation of a Mixture of Nucleotides, β-Glucan and Vitamins C and E Improved the Growth and Health Performance of Olive Flounder, Paralichthys olivaceus

open access: yesFishes, 2023
A twelve-week feeding trial was conducted to investigate the effect of dietary supplementation of a functional immunostimulant mixture (FIM; nucleotides, β-glucan and vitamins C and E) on growth, feed utilization, innate immunity, digestive enzyme ...
Nalin Medagoda   +3 more
doaj   +1 more source

L‐aspartate oxidase provides new insights into fumarate reduction in anaerobic darkness in Synechocystis sp. PCC6803

open access: yesFEBS Letters, EarlyView.
Synechocystis strains deficient in succinate dehydrogenase (SDH) secrete more succinate than the WT under dark anaerobic conditions, supporting that SDH then primarily acts as SDH, not as a fumarate reductase. L‐aspartate oxidase (Laspo) from Synechocystis is functional under anaerobic conditions, reducing fumarate to succinate.
Kateryna Kukil   +3 more
wiley   +1 more source

Profile of Nucleosides and Nucleotides in Donkey's Milk.

open access: yes, 2014
Nucleotides play a crucial role to cellular functions; they can be obtained from the diet or through the nucleotide salvage pathway, however, in particular situations (occurring mainly in newborns) the metabolic demand of nucleotides exceeds the capacity
POLIDORI, Paolo   +5 more
core   +1 more source

Base‐Pairing Properties of Double‐Headed Nucleotides [PDF]

open access: yes, 2019
Nucleotides that contain two nucleobases (double-headed nucleotides) have the potential to condense the information of two separate nucleotides into one. This presupposes that both bases must successfully pair with a cognate strand.
Julie Stendevad   +13 more
core   +1 more source

PEPTIDYL-DONOR SUBSTRATES FOR RIBOSOMAL PEPTIDYL TRANSFERASE - CHEMICAL SYNTHESIS AND BIOLOGICAL-ACTIVITY OF N-ACETYL AMINOACYL DI-NUCLEOTIDES AND TRI-NUCLEOTIDES

open access: yes, 1972
PEPTIDYL-DONOR SUBSTRATES FOR RIBOSOMAL PEPTIDYL TRANSFERASE - CHEMICAL SYNTHESIS AND BIOLOGICAL-ACTIVITY OF N-ACETYL AMINOACYL DI-NUCLEOTIDES AND TRI ...
Julian Mercer (13076475)   +1 more
core   +1 more source

Fluorescent Nanoparticles Synthesized from DNA, RNA, and Nucleotides

open access: yesNanomaterials, 2021
Ubiquitous on Earth, DNA and other nucleic acids are being increasingly considered as promising biomass resources. Due to their unique chemical structure, which is different from that of more common carbohydrate biomass polymers, materials based on ...
Maofei Wang   +3 more
doaj   +1 more source

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

open access: yesFEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise   +5 more
wiley   +1 more source

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