Results 31 to 40 of about 584,446 (261)
Processes Underlining the Action of Pesticides on Ecosystems and Human Organism
Chemistry Journal of Moldova: General, Industrial and Ecological Chemistry, 2017 This article is devoted to the study of the mechanism of action of pesticides as compounds with a high complexing capacity for metals, nucleotides and enzymes.
Elena Saratovskikh
doaj +1 more source
Targeting the Large Subunit of Human Ribonucleotide Reductase for Cancer Chemotherapy
Pharmaceuticals, 2011 Ribonucleotide reductase (RR) is a crucial enzyme in de novo DNA synthesis, where it catalyses the rate determining step of dNTP synthesis. RRs consist of a large subunit called RR1 (α), that contains two allosteric sites and one catalytic site, and a ...
Prem Singh Kaushal +8 more
doaj +1 more source
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
Analysis of Nucleosides and Nucleotides in Milk and Infant Formula [PDF]
, 2013 Nucleotides have been routinely supplemented to infant formulas due to the important roles they play in metabolism and to replicate the higher concentrations typically found in human milk.
Gill, Brendon D.
core
How Should Thiopurine Treatment be Monitored? Methodological Aspects [PDF]
, 2010 Monitoring of thiopurine metabolites is important due to a complex metabolism with large interindividual variation, but the suitability of currently used methods has been questioned.
Peterson, Curt, +11 more
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RNA polymerisation without catalyst from 2’,3’-cyclic nucleotides by drying at air-water interfaces [PDF]
, 2022 For the emergence of life, the abiotic synthesis of RNA from its monomers is a central step. We found alkaline, uncatalysed drying conditions in bulk and at heated air-water interfaces where 2´,3´-cyclic nucleotides polymerised, forming up to 10-mers ...
Sreekar, Wunnava +33 more
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Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
The effect of extracellular nucleotides on cytokine production and phagocytosis of macrophages [PDF]
, 2014 Bacterial sepsis is a severe clinical condition, leading to severe sepsis, septic shock, and death. The complex pathophysiology of sepsis is not yet fully understood.
Hänsli, Christof Karl
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Exploring the Mutated Kinases for Chemoenzymatic Synthesis of N4-Modified Cytidine Monophosphates
MoleculesNucleosides, nucleotides, and their analogues are an important class of molecules that are used as substrates in research of enzymes and nucleic acid, or as antiviral and antineoplastic agents. Nucleoside phosphorylation is usually achieved with chemical
Martyna Koplūnaitė +3 more
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FEBS Letters, EarlyView.CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens +8 more
wiley +1 more source