Frontiers in Bioengineering and Biotechnology, 2020 In our search for novel biocatalysts for the synthesis of nucleic acid derivatives, we found a good candidate in a putative dual-domain hypoxanthine-guanine phosphoribosyltransferase (HGPRT)/adenylate kinase (AMPK) from Zobellia galactanivorans (ZgHGPRT ...
Javier Acosta +9 more
doaj +1 more source
Determination of total potentially available nucleosides in bovine milk [PDF]
, 2010 Bovine colostrum and milk samples were collected from two herds over the course of the first month post-partum, pooled for each herd by stage of lactation and total potentially available nucleosides were determined.
Gill, Brendon D. +2 more
core +2 more sources
Characterisation of multiple substrate-specific (d)ITP/(d)XTPase and modelling of deaminated purine nucleotide metabolism [PDF]
, 2011 To be viable, organisms possess a number of (deoxy)nucleotide phosphohydrolases, which hydrolyze these nucleotides removing them from the active NTP and dNTP pools. Deamination of purine bases can result in accumulation of such nucleotides as ITP, dITP,
Davies, Oluwafemi +3 more
core +2 more sources
First-principles study of high conductance DNA sequencing with carbon nanotube electrodes [PDF]
, 2011 Rapid and cost-effective DNA sequencing at the single nucleotide level might be achieved by measuring a transverse electronic current as single-stranded DNA is pulled through a nano-sized pore.
C. D. Pemmaraju +6 more
core +2 more sources
CTP Synthase 2 From Arabidopsis thaliana Is Required for Complete Embryo Development
Frontiers in Plant Science, 2021 Pyrimidine de novo synthesis is an essential pathway in all organisms. The final and rate-limiting step in the synthesis of the nucleotide cytidine triphosphate (CTP) is catalyzed by CTP synthase (CTPS), and Arabidopsis harbors five isoforms.
Daniel Hickl +2 more
doaj +1 more source
Integrated Multi-Omics Analysis for Inferring Molecular Players in Inclusion Body Myositis
Antioxidants, 2023 Inclusion body myositis (IBM) is an acquired inflammatory myopathy affecting proximal and distal muscles that leads to weakness in patients over 50.
Judith Cantó-Santos +15 more
doaj +1 more source
Comment on "Characterization of the tunneling conductance across DNA bases" [PDF]
, 2007 In a recent article, Zikic {\it et al.} [Phys. Rev. E {\bf 74}, 011919 (2006)] present first-principles calculations of the DNA nucleotides electrical conductance.
Di Ventra, Massimiliano +2 more
core +2 more sources
Palladium-Catalyzed Modification of Unprotected Nucleosides, Nucleotides, and Oligonucleotides
Molecules, 2015 Synthetic modification of nucleoside structures provides access to molecules of interest as pharmaceuticals, biochemical probes, and models to study diseases.
Kevin H. Shaughnessy
doaj +1 more source
Identification of single nucleotides in MoS2 nanopores [PDF]
, 2015 Ultrathin membranes have drawn much attention due to their unprecedented spatial resolution for DNA nanopore sequencing. However, the high translocation velocity (3000-50000 nt/ms) of DNA molecules moving across such membranes limits their usability.
Bulushev, Roman D. +6 more
core +2 more sources
Oncogenic Integration of Nucleotide Metabolism via Fatty Acid Synthase in Non-Hodgkin Lymphoma
Frontiers in Oncology, 2021 Metabolic dysfunctions enabling increased nucleotide biosynthesis are necessary for supporting malignant proliferation. Our investigations indicate that upregulation of fatty acid synthase (FASN) and de novo lipogenesis, commonly observed in many cancers,
Dashnamoorthy Ravi +27 more
doaj +1 more source