Results 21 to 30 of about 511,033 (268)
An Allosteric Inhibitory Site Conserved in the Ectodomain of P2X Receptor Channels
Frontiers in Cellular Neuroscience, 2019 P2X receptors constitute a gene family of cation channels gated by extracellular ATP. They mediate fast ionotropic purinergic signaling in neurons and non-excitable cell types in vertebrates.
Ariel R. Ase +2 more
doaj +1 more source
Angewandte Chemie International Edition, 2011 DNA as an information storage system is simple and at the same time complex owing to the various different arrangements of the four natural nucleotides.[1] The DNA synthesis by DNA polymerases is intriguing, since these enzymes are able to catalyze the elongation of the primer strand by recognizing the DNA template and selecting the corresponding ...
Baccaro, Anna +2 more
openaire +3 more sources
Enzyme-free genetic copying of DNA and RNA sequences
Beilstein Journal of Organic Chemistry, 2018 The copying of short DNA or RNA sequences in the absence of enzymes is a fascinating reaction that has been studied in the context of prebiotic chemistry.
Marilyne Sosson, Clemens Richert
doaj +1 more source
Disruption of nucleotide biosynthesis reprograms mitochondrial metabolism to inhibit adipogenesis
Journal of Lipid ResearchA key organismal response to overnutrition involves the development of new adipocytes through the process of adipogenesis. Preadipocytes sense changes in the systemic nutrient status and metabolites can directly modulate adipogenesis.
Julia A. Pinette +16 more
doaj +1 more source
Physiological and Metabolic Responses of Leymus chinensis Seedlings to Alkali Stress
Plants, 2022 To elucidate the physiological and metabolic mechanism of perennial grass responses to alkali stress, we selected Leymus chinensis (L. chinensis), a salt-tolerant perennial rhizomatous species of the family Poaceae as experimental material.
Ge Yan +4 more
doaj +1 more source
Effect of Deep Dormancy Temperature Cultivation on Meat Quality of Crucian Carp (Carassius auratus)
Foods, 2023 To extend the survival of crucian carp (Carassius auratus) during transportation, the effect of deep dormancy temperature (DDT) cultivation on the crucian carp was investigated by measuring the respiratory rate, survival time, and effect of cooling speed
Yin Zhang +6 more
doaj +1 more source
Thermophilic phosphoribosyltransferases Thermus thermophilus HB27 in nucleotide synthesis
Beilstein Journal of Organic Chemistry, 2018 Phosphoribosyltransferases are the tools that allow the synthesis of nucleotide analogues using multi-enzymatic cascades. The recombinant adenine phosphoribosyltransferase (TthAPRT) and hypoxanthine phosphoribosyltransferase (TthHPRT) from Thermus ...
Ilja V. Fateev +9 more
doaj +1 more source
Organoids in pediatric cancer research
FEBS Letters, EarlyView.Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley +1 more source
FEBS Letters, EarlyView.Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes +4 more
wiley +1 more source
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source