Results 81 to 90 of about 890,466 (364)

Comparison of kinship‐identification methods for robust stock assessment using close‐kin mark–recapture data for Pacific bluefin tuna

Population Ecology, EarlyView.
In this study, we compared three methods for kinship identification using different algorithms in samples of wild Pacific bluefin tuna and generated genotyping data. The three methods resulted in different numbers of inferred kinship pairs for both generated and actual data. Particularly for the half‐sibling pairs, considerable number of false‐positive
Yohei Tsukahara, Reiichiro Nakamichi, Aiko Matsuura, Tetsuya Akita, Atushi Fujiwara, Nobuaki Suzuki   +5 more
wiley   +1 more source

Targeting the Large Subunit of Human Ribonucleotide Reductase for Cancer Chemotherapy

Pharmaceuticals, 2011
Ribonucleotide reductase (RR) is a crucial enzyme in de novo DNA synthesis, where it catalyses the rate determining step of dNTP synthesis. RRs consist of a large subunit called RR1 (α), that contains two allosteric sites and one catalytic site, and a ...
Prem Singh Kaushal, Qun Wan, Chris G. Dealwis, Jianying Kiser, Hai Xu, James W. Fairman, Andrew Zhang, Sanath R. Wijerathna, Md. Faiz Ahmad   +8 more
doaj   +1 more source

The First 5′-Phosphorylated 1,2,3-Triazolyl Nucleoside Analogues with Uracil and Quinazoline-2,4-Dione Moieties: A Synthesis and Antiviral Evaluation

Molecules, 2022
A series of 5′-phosphorylated (dialkyl phosphates, diaryl phosphates, phosphoramidates, H-phosphonates, phosphates) 1,2,3-triazolyl nucleoside analogues in which the 1,2,3-triazole-4-yl-β-D-ribofuranose fragment is attached via a methylene group or a ...
Dmitry A. Tatarinov, Bulat F. Garifullin, Mayya G. Belenok, Olga V. Andreeva, Irina Yu Strobykina, Anna V. Shepelina, Vladimir V. Zarubaev, Alexander V. Slita, Alexandrina S. Volobueva, Liliya F. Saifina, Marina M. Shulaeva, Vyacheslav E. Semenov, Vladimir E. Kataev   +12 more
doaj   +1 more source

FoxO1 signaling in B cell malignancies and its therapeutic targeting

FEBS Letters, EarlyView.
FoxO1 has context‐specific tumor suppressor or oncogenic character in myeloid and B cell malignancies. This includes tumor‐promoting properties such as stemness maintenance and DNA damage tolerance in acute leukemias, or regulation of cell proliferation and survival, or migration in mature B cell malignancies.
Krystof Hlavac, Petra Pavelkova, Laura Ondrisova, Marek Mraz   +3 more
wiley   +1 more source

ROLE OF PURINERGIC RECEPTORS IN IMMUNE RESPONSE

Журнал микробиологии, эпидемиологии и иммунобиологии, 2016
Purine receptors are located on immune and somatic cells of animal and human organisms. Summation of signals from purine and TOLL-like receptors takes place on the level of inflammasome formation and results in summation of the first and second signals ...
I. B. Semenova
doaj   +1 more source

Dietary Supplementation of Brown Seaweed and/or Nucleotides Improved Shrimp Performance, Health Status and Cold-Tolerant Gene Expression of Juvenile Whiteleg Shrimp during the Winter Season

Marine Drugs, 2021
This study was aimed to evaluate the efficiency of Sargassumpolycystum and nucleotides- supplemented diets to improve immune response and cold-tolerance of juvenile Litopenaeus vannamei.
Mohamed Abdel-Rahim, Omar Bahattab, Fatma Nossir, Yahya Al-Awthan, Riad H. Khalil, Radi Mohamed   +5 more
doaj   +1 more source

Extreme accumulation of nucleotides in simulated hydrothermal pore systems [PDF]

, 2007
We simulate molecular transport in elongated hydrothermal pore systems influenced by a thermal gradient. We find extreme accumulation of molecules in a wide variety of plugged pores. The mechanism is able to provide highly concentrated single nucleotides,
Baaske, Philipp, Braun, Dieter, Duhr, Stefan, Lemke, Kono H., Russell, Michael J., Weinert, Franz M.   +5 more
core   +2 more sources

Insights into PI3K/AKT signaling in B cell development and chronic lymphocytic leukemia

FEBS Letters, EarlyView.
This Review explores how the phosphoinositide 3‐kinase and protein kinase B pathway shapes B cell development and drives chronic lymphocytic leukemia, a common blood cancer. It examines how signaling levels affect disease progression, addresses treatment challenges, and introduces novel experimental strategies to improve therapies and patient outcomes.
Maike Buchner
wiley   +1 more source

Improvement in RNA extraction from S. cerevisie by optimization in the autolysis and NH3 hydrolysis

Brazilian Archives of Biology and Technology, 2011
The optimization of autolysis of Saccharomyces cerevisiae from brewery was studied aiming at the maximum ribonucleic acid extraction and yeast extract production.
Antonio Martins Oliveira, Pedro de Oliva Neto   +1 more
doaj   +1 more source

Nutritional Modulation of the Immune Response Mediated by Nucleotides in Canine Leishmaniosis

Microorganisms, 2021
Leishmaniasis is an emerging, uncontrolled, and neglected zoonotic disease. Climate change is contributing to its ongoing global expansion. The dog is the main reservoir; hence the importance of implementing effective treatment, prevention, and control ...
Sergi Segarra
doaj   +1 more source