Results 141 to 150 of about 7,056 (183)

The Enzymatic Mechanism of OAS: How Metal Ions and Quantum Effects Help Activate Innate Immunity. [PDF]

open access: yesACS Omega
Kats P   +11 more
europepmc   +1 more source

COG4849 is a novel family of nucleotidyltransferases

Journal of Molecular Recognition, 2005
Only a minority of currently known protein families is characterized structurally. This makes homology-based structure modeling an essential instrument that can be viewed as the first approximation to experimental determination of protein structure. Using sequence similarity searches, we detected a distant similarity between a family of uncharacterized
Bong-Hyun Kim, Nick V Grishin
exaly   +3 more sources

Transfer RNA nucleotidyltransferase

open access: yes, 1990
Publisher Summary All tRNA molecules contain, at the 3′ terminus, the identical-CCA sequence that is required for their acceptor and transfer functions. In prokaryotic cells, no discrete pattern has emerged. In laboratory strains of Escherichia coli , all tRNA genes sequenced encode the -CCA sequence, and mutant strains devoid of tRNA ...
Deutscher, Murray P   +1 more
openaire   +3 more sources

Phylogeny and Evolution of RNA 3′-Nucleotidyltransferases in Bacteria

Journal of Molecular Evolution, 2019
The tRNA nucleotidyltransferases and poly(A) polymerases belong to a superfamily of nucleotidyltransferases. The amino acid sequences of a number of bacterial tRNA nucleotidyltransferases and poly(A) polymerases have been used to construct a rooted, neighbor-joining phylogenetic tree.
George H Jones
exaly   +3 more sources

[14] Stereochemistry of selected phosphotransferases and nucleotidyltransferases

open access: yes, 1982
Publisher Summary In recognition of the experimental imperatives for carrying out stereochemical analyses of chemical reactions, this chapter deals with the methodologies of such research. It describes methods for synthesizing chirally substituted phosphorothioate analogs of biological phosphates.
Perry A. Frey   +5 more
openaire   +2 more sources

Feedback Inhibition of Bacterial Nucleotidyltransferases by Rare Nucleotide l-Sugars Restricts Substrate Promiscuity

open access: yesJournal of the American Chemical Society, 2023
Bacterial glycomes are rich in prokaryote-specific or “rare” sugars that are absent in mammals. Like common sugars found across organisms, rare sugars are typically activated as nucleoside diphosphate sugars (NDP-sugars) by nucleotidyltransferases.
Meng Zheng, Hanee Kim, Tania J Lupoli
exaly   +2 more sources

tRNA‐nucleotidyltransferases: Highly unusual RNA polymerases with vital functions

open access: yesFEBS Letters, 2010
tRNA-nucleotidyltransferases are fascinating and unusual RNA polymerases responsible for the synthesis of the nucleotide triplet CCA at the 3′-terminus of tRNAs.
Mario Mörl
exaly   +2 more sources

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