Results 111 to 120 of about 1,447,270 (322)
The inhibitory effect of stimulation of a thalamic nucleus on neuronal activity in the motor cortex [PDF]
Choh‐Luh Li
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Microglia act as tumor suppressors during brain metastasis colonization but shift to a tumor‐promoting role after melanoma brain metastases form. NF‐κB/RelA signaling emerges as a key driver of this phenotypic shift. Targeting this pathway reprograms microglia into a pro‐inflammatory state, enhancing antitumor immunity and immune checkpoint inhibitor ...
Noam Savion‐Gaiger+2 more
wiley +1 more source
B‐cell chronic lymphocytic leukemia (B‐CLL) and monoclonal B‐cell lymphocytosis (MBL) show altered proteomes and phosphoproteomes, analyzed using mass spectrometry, protein microarrays, and western blotting. Identifying 2970 proteins and 316 phosphoproteins, including 55 novel phosphopeptides, we reveal BCR and NF‐kβ/STAT3 signaling in disease ...
Paula Díez+17 more
wiley +1 more source
Global Features of Nucleus-Nucleus Collisions in the Ultrarelativistic Domain [PDF]
HIJING generator simulation of nucleus-nucleus collisions at ultrarelativistic energies are presented. Is shown, that the global characteristics of nucleus-nucleus collisions, such as of distribution of a charge multiplicity, total and electromagnetic transverse energy over pseudorapidity are rather sensitive to some predictions of formation models of ...
arxiv
Ubiquitination of transcription factors in cancer: unveiling therapeutic potential
In cancer, dysregulated ubiquitination of transcription factors contributes to the uncontrolled growth and survival characteristics of tumors. Tumor suppressors are degraded by aberrant ubiquitination, or oncogenic transcription factors gain stability through ubiquitination, thereby promoting tumorigenesis.
Dongha Kim, Hye Jin Nam, Sung Hee Baek
wiley +1 more source
THE POSITION OF THE CELL NUCLEUS IN PATHWAYS OF HYDROGEN TRANSFER: CYTOCHROME C, FLAVOPROTEINS, GLUTATHIONE, AND ASCORBIC ACID [PDF]
Herbert Stern, Sari Timonen
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DBpedia: A Nucleus for a Web of Open Data
S. Auer+5 more
semanticscholar +1 more source
Targeted protein degradation in oncology: novel therapeutic opportunity for solid tumours?
Current anticancer therapies are limited by the occurrence of resistance and undruggability of most proteins. Targeted protein degraders are novel, promising agents that trigger the selective degradation of previously undruggable proteins through the recruitment of the ubiquitin–proteasome machinery. Their mechanism of action raises exciting challenges,
Noé Herbel, Sophie Postel‐Vinay
wiley +1 more source
The Demonstration of a Nucleus in the Cell of a Staphylococcus [PDF]
Georges Knaysi
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