Results 111 to 120 of about 2,101,156 (300)

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

The classical field created in early stages of high energy nucleus-nucleus collisions

, 2008
We show that a special choice of light-cone gauge can greatly simplify the calculation of the classical color field created in the initial stages of nucleus-nucleus collisions.
Blaizot, Jean-Paul, Mehtar-Tani, Yacine
core   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Quarkonium measurements in nucleus–nucleus collisions with ALICE

Nuclear Physics A, 2019
Quarkonia, i.e. bound states of $b\bar{b}$ and $c\bar{c}$ quarks, are powerful observables to study the properties of nuclear matter under extreme conditions. The formation of a Quark-Gluon Plasma (QGP), which is predicted by lattice QCD calculations at high temperatures as reached at LHC energies, has a strong influence on the production and behavior ...
Dillenseger, Pascal and Acharya, S, Acosta, F. T, Adamova, D, Adolfsson, J, Aggarwal, M. M, Rinella, G. Aglieri and Agnello, M, Agrawal, N, Ahammed, Z, Ahn, S. U, Aiola, S, Akindinov, A, Al-Turany, M, Alam, S. N, Albuquerque, D. S. D, Aleksandrov, D, Alessandro, B, Alfaro Molina, R, Ali, Y, Alici, A, Alkin, A, Alme, J, Alt, T, Altenkamper, L, Altsybeev, I and Anaam, M. N, Andrei, C, Andreou, D, Andrews, H. A, Andronic, A, Angeletti, M, Anguelov, V and Anson, C, Anticic, T, Antinori, F, Antonioli, P, Anwar, R, Apadula, N, Aphecetche, L, Appelshaeuser, H, Arcelli, S, Arnaldi, R, Arnold, O. W, Arratia, M, Arsene, I. C, Arslandok, M, Augustinus, A, Averbeck, R, Azmi, M. D, Badala, A, Baek, Y. W, Bagnasco, S, Bailhache, R, Bala, R, Baldisseri, A, Ball, M, Baral, R. C, Barbano, A. M, Barbera, R, Barile, F, Barioglio, L, Barnafoldi, G. G, Barnby, L. S, Barret, V and Bartalini, P, Barth, K, Bartsch, E, Bastid, N, Basu, S, Batigne, G, Batyunya, B, Batzing, P. C, Bazo Alba, J. L, Bearden, I. G, Beck, H, Bedda, C, Behera, N. K, Belikov, I and Bellini, F, Bello Martinez, H, Bellwied, R, Beltran, L. G. E, Belyaev, V and Bencedi, G, Beole, S, Bercuci, A, Berdnikov, Y, Berenyi, D, Bertens, R. A, Berzano, D, Betev, L, Bhaduri, P. P, Bhasin, A, Bhat, I. R, Bhatt, H, Bhattacharjee, B, Bhom, J, Bianchi, A, Bianchi, L, Bianchi, N, Bielcik, J, Bielcikova, J, Bilandzic, A, Biro, G, Biswas, R, Biswas, S, Blair, J. T, Blau, D, Blume, C, Boca, G, Bock, F, Bogdanov, A, Boldizsar, L, Bombara, M, Bonomi, G, Bonora, M, Borel, H, Borissov, A, Borri, M, Botta, E, Bourjau, C, Bratrud, L, Braun-Munzinger, P, Bregant, M, Broker, T. A, Broz, M, Brucken, E. J, Bruna, E, Bruno, G. E, Budnikov, D, Buesching, H, Bufalino, S, Buhler, P, Buncic, P, Busch, O, Buthelezi, Z, Butt, J. B, Buxton, J. T, Cabala, J, Caffarri, D, Caines, H, Caliva, A, Calvo Villar, E, Camacho, R. S, Camerini, P, Capon, A. A, Carena, F, Carena, W, Carnesecchi, F, Castellanos, J. Castillo and Castro, A. J, Casula, E. A. R, Ceballos Sanchez, C, Chandra, S, Chang, B, Chang, W, Chapeland, S, Chartier, M, Chattopadhyay, S, Chauvin, A, Cheshkov, C, Cheynis, B, Barroso, V. Chibante and Chinellato, D. D, Cho, S, Chochula, P, Chowdhury, T, Christakoglou, P, Christensen, C. H, Christiansen, P, Chujo, T, Chung, S. U, Cicalo, C, Cifarelli, L, Cindolo, F, Cleymans, J, Colamaria, F, Colella, D, Collu, A, Colocci, M, Concas, M, Balbastre, G. Conesa and del Valle, Z. Conesa and Contreras, J. G, Cormier, T. M, Morales, Y. Corrales and Cortese, P, Cosentino, M. R, De Caro, A, De Gruttola, D, De Pasquale, S, Fantoni, A, Fernandez Tellez, A, Ferretti, A, Giubilato, P, Gulbrandsen, K, Hills, C, Kobdaj, C, Loncar, P, Lunardon, M, Moretto, S, Natal da Luz, H, Nielsen, B. S, Noris, J. C. C, Ogino, M, Paul, B, Scapparone, E, Scarlassara, F, Sefcik, M, Sevcenco, A, Sharma, N, Soramel, F, Suaide, A. A. P, Suleymanov, M, Terrevoli, C, Virgili, T, Volpe, G, Yalcin, S, Zhou, Y   +230 more
openaire   +15 more sources

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source

Relating high-energy lepton-hadron, proton-nucleus and nucleus-nucleus collisions through geometric scaling

, 2004
A characteristic feature of small-x lepton-proton data from HERA is geometric scaling -- the fact that over a wide range of x and Q^2 all data can be described by a single variable $Q^2/Q_{sat}^2(x)$, with all x-dependence encoded in the so-called ...
C. Adloff, Carlos A. Salgado, G. J. Alner, M. Arneodo, M. Arneodo, M. Lublinsky, M. R. Adams, N. Armesto, N. N. Nikolaev, Néstor Armesto, Urs Achim Wiedemann   +10 more
core   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

Wounded Constituents

, 2012
The concept of the "wounded" hadronic constituents is formulated. Preliminary estimates indicate that it may help to understand the transverse mass dependence of particle production in hadron-nucleus and nucleus-nucleus collisions.Comment: 14 pages, 2 ...
Bialas, A.
core   +1 more source