Results 111 to 120 of about 1,379,939 (300)

Probe-free optical chromatin deformation and measurement of differential mechanical properties in the nucleus

open access: yeseLife
The nucleus is highly organized to facilitate coordinated gene transcription. Measuring the rheological properties of the nucleus and its sub-compartments will be crucial to understand the principles underlying nuclear organization.
Benjamin Seelbinder   +7 more
doaj   +1 more source

Dynamic gating in the nucleus accumbens: Behavioral state-dependent synchrony with the prefrontal cortex and hippocampus [PDF]

open access: yes, 2008
Contextual and sensory information, goals, and the motor plan to achieve them are integrated in the nucleus accumbens (NA). Although this integration needs flexibility to operate in a variety of environments, models of NA function rarely consider ...
Rifat J. Hussain   +2 more
core  

The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer

open access: yesMolecular Oncology, EarlyView.
Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad   +2 more
wiley   +1 more source

Picornaviruses and nuclear functions: targeting a cellular compartment distinct from the replication site of a positive-strand RNA virus

open access: yesFrontiers in Microbiology, 2015
The compartmentalization of DNA replication and gene transcription in the nucleus and protein production in the cytoplasm is a defining feature of eukaryotic cells.
Dylan eFlather, Bert L Semler
doaj   +1 more source

Quarkonium measurements in nucleus–nucleus collisions with ALICE

open access: yesNuclear Physics A, 2019
Quarkonia, i.e. bound states of $b\bar{b}$ and $c\bar{c}$ quarks, are powerful observables to study the properties of nuclear matter under extreme conditions. The formation of a Quark-Gluon Plasma (QGP), which is predicted by lattice QCD calculations at high temperatures as reached at LHC energies, has a strong influence on the production and behavior ...
Dillenseger   +660 more
openaire   +15 more sources

Rabl's model of the interphase chromosome arrangement tested in Chinise hamster cells by premature chromosome condensation and laser-UV-microbeam experiments [PDF]

open access: yes, 1982
In 1885 Carl Rabl published his theory on the internal structure of the interphase nucleus. We have tested two predictions of this theory in fibroblasts grown in vitro from a female Chinese hamster, namely (1) the Rabl-orientation of interphase ...
Baumann, H.   +6 more
core   +1 more source

Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

open access: yesMolecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico   +5 more
wiley   +1 more source

Linking actions to outcomes : the role of the posterior pedunculopontine tegmental nucleus in instrumental learning [PDF]

open access: yes, 2012
Located in the mesopontine tegmentum, the pedunculopontine tegmental nucleus (PPTg) is comprised principally of glutamatergic, cholinergic and GABAergic neurons.
MacLaren, Duncan A. A.
core   +2 more sources

Akt-ing Up Just About Everywhere: Compartment-Specific Akt Activation and Function in Receptor Tyrosine Kinase Signaling

open access: yesFrontiers in Cell and Developmental Biology, 2019
The serine/threonine kinase Akt is a master regulator of many diverse cellular functions, including survival, growth, metabolism, migration, and differentiation.
Michael G. Sugiyama   +5 more
doaj   +1 more source

Edinger-Westphal Nucleus [PDF]

open access: yes, 2008
This report contains a summary of expression patterns for genes that are enriched in the Edinger-Westphal nucleus (EW) of the midbrain. All data are derived from the Allen Brain Atlas (ABA) in situ hybridization mouse project.
Josh Burnell   +6 more
core   +1 more source

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