Results 231 to 240 of about 473,018 (289)

Intervertebral disc human nucleus pulposus cells associated with back pain trigger neurite outgrowth in vitro and pain behaviors in rats

Science Translational Medicine, 2023
Low back pain (LBP) is often associated with the degeneration of human intervertebral discs (IVDs). However, the pain-inducing mechanism in degenerating discs remains to be elucidated.
Wensen Jiang, Juliane D. Glaeser, Giselle Kaneda, J. Sheyn, Jacob T. Wechsler, Stephen Stephan, Khosrowdad Salehi, J. Chan, W. Tawackoli, P. Avalos, Christopher Johnson, Chloe Castaneda, L. Kanim, T. Tanasansomboon, J. Burda, O. Shelest, Haneen Yameen, Tiffany G. Perry, Michael Kropf, Jason M. Cuellar, D. Seliktar, Hyun W. Bae, Laura S. Stone, Dmitriy Sheyn   +23 more
semanticscholar   +1 more source

SIRT1 alleviates IL-1β induced nucleus pulposus cells pyroptosis via mitophagy in intervertebral disc degeneration.

International Immunopharmacology, 2022
Inflammatory stress of nucleus pulposus cells (NPCs) plays an important role in the pathogenesis of intervertebral disc degeneration (IVDD). Pyroptosis and NLRP3 inflammasome activation have been reported aggravating IVDD.
Zhaoxin Ma, Pan Tang, Weisheng Dong, Yang Lu, B. Tan, Nian Zhou, J. Hao, Jieliang Shen, Zhenming Hu   +8 more
semanticscholar   +1 more source

On the Poisson's Ratio of the Nucleus Pulposus

Journal of Biomechanical Engineering, 2013
Existing experimental data on the Poisson's ratio of nucleus pulposus (NP) tissue is limited. This study aims to determine whether the Poisson's ratio of NP tissue is strain-dependent, strain-rate-dependent, or varies with axial location in the disk.
Farrell, Mark, Riches, Philip
openaire   +5 more sources

Combined nucleus pulposus augmentation and annulus fibrosus repair prevents acute intervertebral disc degeneration after discectomy

Science Translational Medicine, 2020
Tissue-engineered therapies targeting the nucleus pulposus and annulus fibrosus prevent intervertebral disc degeneration after discectomy in sheep. Strategic lumbar support Discectomy is a common treatment for herniated or “slipped” intervertebral discs ...
Stephen R. Sloan, C. Wipplinger, Sertaç Kırnaz, Rodrigo Navarro-Ramirez, Franziska A. Schmidt, Duncan McCloskey, T. Pannellini, A. Schiavinato, R. Härtl, L. Bonassar   +9 more
semanticscholar   +1 more source

HERNIATION OF THE NUCLEUS PULPOSUS

The Journal of Nervous and Mental Disease, 1945
In this study of 100 cases in which a herniated nucleus pulposus was removed, all patients had sciatic pain, and, with one exception, all had back pain, preceding or coincident with the sciatica. Roentgenographic or clinical examination revealed an unstable lumbosacral joint in eighty-four cases.
Edwin M. Deery, George L. Hagman, Alan Def. Smith   +2 more
openaire   +2 more sources

HERNIATION OF THE NUCLEUS PULPOSUS [PDF]

The Lancet, 1952
J.R. Armstrong, W.S.C. Copeman
  +9 more sources

Viscoelastic properties of nucleus pulposus

Journal of Back and Musculoskeletal Rehabilitation, 1997
Although there have been many studies on the mechanical properties of the annulus fibrosus [1], the fibrous outer layers of the intervertebral disc, there have been fewer studies published on the mechanical properties of its soft centre, the nucleus pulposus [2-4].
David W.L. Hukins, J.C. Leahy
openaire   +3 more sources

Notochord to Nucleus Pulposus Transition

Current Osteoporosis Reports, 2015
A tissue that commonly deteriorates in older vertebrates is the intervertebral disc, which is located between the vertebrae. Age-related changes in the intervertebral discs are thought to cause most cases of back pain. Back pain affects more than half of people over the age of 65, and the treatment of back pain costs 50-100 billion dollars per year in ...
Brian D. Harfe, Lisa Y. Lawson
openaire   +3 more sources

Reflections on the Nucleus Pulposus

Rivista di Neuroradiologia, 1998
The intervertebral disc is usually divided into two parts, the anulus fibrosus and the nucleus pulposus. However, they are not considered two separate anatomic parts since one is essentially part of the other and this should be borne in mind to understand the process of ageing.
Luigi Simonetti, C. Barbara
openaire   +2 more sources

Enzyme Dissolution of the Nucleus Pulposus

Nature, 1963
THOMAS showed the surprising susceptibility of cartilage to the action of papain when he produced collapse of the ears of young rabbits by injecting the enzyme intravenously1,2. All cartilaginous tissue of the body was affected; the epiphyseal cartilages appeared to be particularly sensitive.
Paul J. Garvin, Lyman Smith, Robert B. Jennings, Robert M. Gesler   +3 more
openaire   +3 more sources