Results 41 to 50 of about 113,606 (254)

Fisher, Neyman-Pearson or NHST? A Tutorial for Teaching Data Testing

open access: yesFrontiers in Psychology, 2015
Despite frequent calls for the overhaul of null hypothesis significance testing (NHST), this controversial procedure remains ubiquitous in behavioral, social and biomedical teaching and research.
Jose D. Perezgonzalez
doaj   +1 more source

Overview on the Null Hypothesis Significance Test

open access: yes, 2021
For decades, waxing and waning, there has been an ongoing debate on the values and problems of the ubiquitously used null hypothesis significance test (NHST). With the start of the replication crisis, this debate has flared-up once again, especially in the psychology and psychological methods literature.
Noah van Dongen, Leonie van Grootel
openaire   +2 more sources

Antibiofilm activity of a chionodracine‐derived peptide by NMR‐based metabolomics of cell‐free supernatant of Acinetobacter baumannii clinical strains

open access: yesFEBS Open Bio, EarlyView.
KHS‐Cnd peptide is able to impair biofilm formation and disaggregate mature biofilms in Acinetobacter baumannii clinical isolates. Differences in extracellular metabolites reflect changes in biofilm metabolism due to KHS‐Cnd treatment. Among the differentially represented extracellular metabolites upon KHS‐Cnd treatment, the significantly altered ...
Fernando Porcelli   +9 more
wiley   +1 more source

On the Power of Some Nonparametric Isotropy Tests

open access: yesActa Universitatis Lodziensis. Folia Oeconomica, 2020
In this paper, properties of nonparametric significance tests verifying the random field isotropy hypothesis are discussed. In particular, the subject of the conducted analysis is the probability of rejecting the null hypothesis when it is true.
Krzysztof Szymoniak-Książek
doaj   +1 more source

Engineering tandem VHHs to target different epitopes to enhance antibody‐dependent cell‐mediated cytotoxicity

open access: yesFEBS Open Bio, EarlyView.
Tandem VHH targeting distinct EGFR epitopes were engineered into a monovalent bispecific antibody (7D12‐EGA1‐Fc) with more potent ADCC without increasing affinity to EGFR. Structural modeling of 7D12‐EGA1‐Fc showed cross‐linking of separate EGFR domains to enhance CD16a engagement on NK cells.
Yuqiang Xu   +5 more
wiley   +1 more source

The hazards of dealing with response time outliers

open access: yesFrontiers in Psychology, 2023
The presence of outliers in response times can affect statistical analyses and lead to incorrect interpretation of the outcome of a study. Therefore, it is a widely accepted practice to try to minimize the effect of outliers by preprocessing the raw data.
Ivan I. Vankov
doaj   +1 more source

Differential regulation of ZFAS1 splice variants by endoplasmic reticulum stress in hepatocyte cell lines

open access: yesFEBS Open Bio, EarlyView.
ZFAS1 is a lncRNA promoting cell proliferation and migration, exhibiting high expression in various cancers. It is conserved, widely expressed, and produces multiple splice variants with unclear roles. We identified several splice variants in hepatocyte models, and found that inhibiting or suppressing regulators of the unfolded protein response (PERK ...
Sébastien Soubeyrand   +2 more
wiley   +1 more source

What would judgment and decision making research be like if we took a Bayesian approach to hypothesis testing? [PDF]

open access: yesJudgment and Decision Making, 2011
Judgment and decision making research overwhelmingly uses null hypothesis significance testing as the basis for statistical inference. This article examines an alternative, Bayesian approach which emphasizes the choice between two competing hypotheses ...
William J. Matthews
doaj  

Next steps after airing disagreement on a scientific issue with policy implications: a meta-analysis, multi-lab replication and adversarial collaboration

open access: yesBMC Biology, 2023
Canadian policymakers are interested in determining whether farmed Atlantic salmon, frequently infected with Piscine orthoreovirus (PRV), may threaten wild salmon populations in the Pacific Northwest.
Shinichi Nakagawa, Malgorzata Lagisz
doaj   +1 more source

Exon 7 splicing of ERα predicts poor prognosis and increases phenotypic heterogeneity in luminal a subtype breast cancer

open access: yesFEBS Open Bio, EarlyView.
ERα splice variant ERα∆7 lacks the C‐terminus, and its expression may change phenotypes of breast cancers. Our results showed that ERα∆7 is found in the luminal A subtype, and elevated ERα∆7 levels are linked to improved cell survival with lower proliferation and migration.
Long Wai Tsui   +10 more
wiley   +1 more source

Home - About - Disclaimer - Privacy