Results 51 to 60 of about 44,879 (298)

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

open access: yesFEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson   +7 more
wiley   +1 more source

Specificity of Sentence Processing in the Canonical Briefer Process of the Nullity of Marriage

open access: yesKościół i Prawo, 2018
The briefer process of the nullity of marriage is one of the most important reform introduced by Pope Francis in motu proprio Mitis Iudex Dominus Iesus.
Aleksandra Rybaczek
doaj   +1 more source

Sovereign Nothingness: Pyotr Chaadaev's Political Theology [PDF]

open access: yes, 2019
This paper speculatively reconstructs the unique intervention that Pyotr Chaadaev, the early nineteenth-century Russian thinker, made into the political-theological debate.
Chepurin, Kirill, Dubilet, Alex
core  

A sharp upper bound of the nullity of a connected graph in terms of order and maximum degree

open access: yes, 2020
The nullity η ( G ) of G is the multiplicity of 0 as an eigenvalue of A ( G ) . In this paper, we completely solve the following conjecture proposed by Zhou, Wong and Sun in [Linear Algebra and its Applications, 555 (2018) 314-320]: Let G be a connected ...
Zhiwen Wang, Ji-Ming Guo
semanticscholar   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

open access: yesMolecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero   +11 more
wiley   +1 more source

Index and nullity of proper biharmonic maps in spheres [PDF]

open access: yesCommunications in Contemporary Mathematics, 2019
In recent years, the study of the bienergy functional has attracted the attention of a large community of researchers, but there are not many examples where the second variation of this functional has been thoroughly studied.
S. Montaldo, C. Oniciuc, A. Ratto
semanticscholar   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

open access: yesMolecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice   +16 more
wiley   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

open access: yesMolecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu   +10 more
wiley   +1 more source

On The Nullity of Generalized Rooted T-Tuple With B-Bridge Coalescence Graphs

open access: yesScience Journal of University of Zakho, 2016
In this paper, we determine the nullity of generalized rooted t-tuple coalescence graphs and the nullity of generalized rooted t-tuple with b-bridge coalescence graphs. Finally, the nullity of generalized rooted t-tuple with b-path coalescence graph and (
Nechirvan B. Ibrahim
doaj  

El alcance del control judicial de la inadmisión de la acción de nulidad; a propósito de la Sentencia del TS de 1 de diciembre de 2020

open access: yesRevista Vasca de Administración Pública, 2021
This comment approaches the most controversial facets of the invalidity action of administrative acts. It is particularly focused on the admission process of the invalidity action, and on the scope of the limits of the review of administrative acts ...
Carmen Agoués Mendizabal
doaj   +1 more source

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