Results 41 to 50 of about 167,661,519 (247)
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Scheduling stochastic jobs on a single machine to minimize weighted number of tardy jobs
Kuwait Journal of Science, 2013 An important scheduling problem in manufacturing and service organizations is the on-time deliveries of products and services. This paper addresses a single machine scheduling problem wherein processing times and/or due-dates are random variables and ...
H. M. SOROUSH
doaj
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
A Decision Support System for Dynamic Job-Shop Scheduling Using Real-Time Data with Simulation
Mathematics, 2019 The wide usage of information technologies in production has led to the Fourth Industrial Revolution, which has enabled real data collection from production tools that are capable of communicating with each other through the Internet of Things (IoT ...
Ahmet Kursad Turker +5 more
doaj +1 more source
Epigenetic reprogramming of lineage switching in cancer
FEBS Letters, EarlyView.Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı +4 more
wiley +1 more source
Nature-Inspired Metaheuristics for Two-Agent Scheduling with Due Date and Release Time
Complexity, 2020 This paper delves into a two-agent scheduling problem in which two agents are competing for a single resource. Each agent has a set of jobs to be processed by a single machine.
Hongwei Li +4 more
doaj +1 more source
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
Scheduling Of 2-Operation Jobs On A Single Machine To Minimize The Number Of Tardy Jobs [PDF]
, 2003 This study focuses on the study of a unique but commonly occurring manufacturing problem of scheduling of customized jobs consisting of two operations on a single multi-purpose machine with the performance objective of minimizing the number of tardy jobs
Yeleswarapu, Radhika M
core
Single-machine scheduling with trade-off between number of tardy jobs and resource allocation
, 1996 We consider a single-machine scheduling problem in which job processing times are controllable through the allocation of a limited resource. The amount of resource consumption of a job is assumed to be linearly related to the job processing time.
Cheng, TCE +5 more
core +1 more source
Two-agent scheduling with generalized due dates
Asian Journal of Shipping and Logistics, 2018 In this paper we consider the problems of order pickers in warehouse management. We interpret the problems as machine scheduling problems in which the due dates are not specified for the jobs but for their positions.
Myoung-Ju Park +2 more
doaj +1 more source