Results 51 to 60 of about 167,661,519 (247)
FEBS Letters, EarlyView.How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
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HEURISTICS FOR MINIMIZING THE NUMBER OF TARDY JOBS ON A SINGLE MACHINE WITH RELEASE TIME
South African Journal of Industrial Engineering, 2012 <p>ENGLISH ABSTRACT: This paper considers the problem of minimizing the number of tardy jobs with release time on a single machine. Given that the problem has been classified as strongly NP-Hard, three heuristics (EOO, HR2, and HR3) are proposed ...
E. O. Oyetunji, A. E. Oluleye
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KPI Science News, 2019 Background. The problem of minimization of total weighted tardiness can be solved either exactly by the corresponding models or heuristically. As of October 2019, nearly the best heuristic is one based on using remaining available and processing periods.
Vadim V. Romanuke
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IEEE Access, 2020 This paper considers a time window periodic maintenance strategy with different duration windows and job scheduling activities in a single machine environment.
Ammar A. Qamhan +5 more
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Artificial molecular machines and motors—Design and control of nanoscale motion
FEBS Letters, EarlyView.Molecules are constantly moving because of thermal fluctuations, but random motion alone cannot be exploited to perform directional tasks. Artificial molecular machines use chemical, electrical, or light energy to bias this motion. Molecular shuttles, rotary motors, and supramolecular pumps illustrate how nanoscale movement can be controlled and ...
Leonardo Andreoni, Alberto Credi
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Applied SciencesThis paper presents a robust and adaptable framework for predictive–reactive rescheduling in identical parallel-machine environments. The proposed Multi-Purpose Intelligent Utility (MIU) methodology utilizes heuristic methods to efficiently address the ...
Mahmut İbrahim Ulucak, Hadi Gökçen
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FEBS Letters, EarlyView.Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise +5 more
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Smaller is better: nanobodies meet NMR
FEBS Letters, EarlyView.Nanobodies are single‐domain antigen‐binding fragments derived from camelid heavy chain antibodies. Their small size, high stability, and exceptional specificity make nanobodies uniquely useful probes for NMR studies of protein dynamics, transient conformational states, and protein–protein interactions.
Oleg Y. Dmitriev
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Membrane composition and thermodynamic identity as boundaries of life for synthetic cell research
FEBS Letters, EarlyView.What makes a cell a cell? The boundary of a living cell is not just a wall. Read as a Markov blanket, the membrane separates internal from external states, generating identity and non‐equilibrium order. Can this identity be rebuilt from scratch in a synthetic cell?
Caterina Presutti, Bert Poolman
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Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
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