Results 121 to 130 of about 3,517 (303)
Molecular Oncology, EarlyView.Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang +12 more
wiley +1 more source
Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer
Molecular Oncology, EarlyView.COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann +61 more
wiley +1 more source
Abstract numeration systems and recognizability [PDF]
, 2007 In this talk, I will present some results concerning multiplication by a constant in an abstract numeration system built on a bounded language. More precisely, we will show that this operation does not preserve regularity, and therefore cannot be ...
Charlier, Emilie
core
A Decision Problem for Ultimately Periodic Sets in Non-standard Numeration Systems
, 2009 peer reviewedConsider a non-standard numeration system like the one built over the Fibonacci sequence where nonnegative integers are represented by words over {0,1} without two consecutive 1.
Charlier, Emilie +3 more
core +1 more source
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
Numeration systems as dynamical systems–introduction
, 2006 A numeration system originally implies a digitization of real numbers, but in this paper it rather implies a compactification of real numbers as a result of the digitization. By definition, a numeration system with $G$, where $G$ is a nontrivial closed multiplicative subgroup of ${\mathbb{R}}_+$, is a nontrivial compact metrizable space $Ω$ admitting a
openaire +3 more sources
Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Structure of the minimal automaton of a numeration language [PDF]
, 2010 peer reviewedWe study the structure of automata accepting the greedy representations of N in a wide class of numeration systems. We describe the conditions under which such automata can have more than one strongly connected component and the form of any ...
Charlier, Emilie +3 more
core
Molecular Oncology, EarlyView.Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova +14 more
wiley +1 more source