Results 61 to 70 of about 41,790 (269)

Uncertainty Quantification

Uncertainty quantification (UQ) is concerned with including and characterising uncertainties in mathematical models. Major steps include the proper description of system uncertainties, analysis and efficient quantification of uncertainties in predictions

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Efficient Iterative Arbitrary High Order Methods: Adaptivity and Structure Preservation [PDF]

Since its introduction in the late 17th century, in the independent works of Sir Isaac Newton and Gottfried Wilhelm Leibniz, differential calculus has shown to be a very powerful tool for the description of natural phenomena and technological processes ...
Micalizzi, Lorenzo
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EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

Modeling eye gaze velocity trajectories using GANs with spectral loss for enhanced fidelity

Scientific Reports
Accurate modeling of eye gaze dynamics is essential for advancement in human-computer interaction, neurological diagnostics, and cognitive research. Traditional generative models like Markov models often fail to capture the complex temporal dependencies ...
Shailendra Bhandari, Pedro Lencastre, Rujeena Mathema, Alexander Szorkovszky, Anis Yazidi, Pedro G. Lind   +5 more
doaj   +1 more source

VaSP: Vascular Fluid–Structure Interaction Pipeline

SoftwareX
A variety of commercial and open-source software packages exist for modeling blood flow dynamics and vascular wall mechanics of cardiovascular systems via fluid–structure interaction simulations (FSI).
Kei Yamamoto, David A. Bruneau, Johannes Ring, Jørgen S. Dokken, Kristian Valen-Sendstad   +4 more
doaj   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Enhanced visibility graph for EEG classification

Frontiers in Neuroscience
Electroencephalography (EEG) holds immense potential for decoding complex brain patterns associated with cognitive states and neurological conditions. In this paper, we propose an end-to-end framework for EEG classification that integrates power spectral
Asma Belhadi, Pedro G. Lind, Pedro G. Lind, Pedro G. Lind, Youcef Djenouri, Youcef Djenouri, Anis Yazidi, Anis Yazidi   +7 more
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Multi-GPU Acceleration for Finite Element Analysis in Structural Mechanics

Applied Sciences
This work evaluates the computing performance of finite element analysis in structural mechanics using modern multi-GPU systems. We can avoid the usual memory limitations when using one GPU device for many-core computing using multiple GPUs for ...
David Herrero-Pérez, Humberto Martínez-Barberá   +1 more
doaj   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source